49ers vs Bears Prediction 12/28/25 NFL Picks Today

The Chicago Bears and the San Francisco 49ers meet in week 17 NFL action from Levi’s Stadium on Sunday. We will look at this from a betting perspective and determine the best bets for this game. Here’s a 49ers vs Bears Prediction.

Chicago Bears Recap

The Chicago Bears come into this game looking to add on to their 22-16 win over the Green Bay Packers last time out to sit at 11-4 this season. After this game, Chicago will head home for a game against the Detroit Lions.

Bears Clinch Playoff Spot

Caleb Williams has thrown for 3,400 yards, 23 touchdowns and 6 interceptions on 57.8% passing while D’Andre Swift has rushed for 993 yards and 7 touchdowns and Kyle Monangai has 731 rushing yards and 5 TDs. DJ Moore has a team-high 48 catches for 664 yards and 6 TDs and Rome Odunze has 44 catches for 551 yards and 6 TDs as well and Colston Loveland has 528 receiving yards and 4 TDs. Luther Burden III has 36 catches for 479 yards and two more Bears have 300+ receiving yards respectively this season. On defense, Tremaine Edmunds leads the Bears with 95 total tackles including 47 solo tackles and 4 interceptions while Kevin Byard III has a team-high 6 interceptions. Montez Sweat also has a team-high 9.5 sacks as well. As a unit, Chicago’s defense has combined for 31 sacks and 21 interceptions so far this season.

Why the Chicago Bears will win

Chicago Bears Player Prop Facts

San Francisco 49ers Recap

The San Francisco 49ers come into this game looking to add on to their 48-27 win over Indianapolis last time out to sit at 11-4 this season. After this game, San Francisco will head home for a game against the Seattle Seahawks to close out the regular season. 

49ers Win 5 Straight

Mac Jones has thrown for 2,151 yards, 13 touchdowns and 6 interceptions on 69.6% passing while Brock Purdy has thrown for 1,737 yards, 17 touchdowns and 8 interceptions on 68.8% passing. Christian McCaffrey has a team-high 1,039 rushing yards and 9 TDs while also leading the 49ers in receiving with 92 grabs for 849 yards and 7 touchdowns. Ricky Pearsall has 443 receiving yards and 31 receptions while Kendrick Bourne has 499 receiving yards and Jauan Jennings has 566 receiving yards and 8 TDs. George Kittle also has 599 receiving yards and 52 catches along with 7 touchdowns this season. Three more 49ers have 150+ receiving yards as well on the year. On defense, Dee Winters has a team-high 92 total tackles. Bryce Huff and Clelin Ferrell each have a team-high 4 sacks. As a unit, San Francisco’s defense has combined for 18 sacks and 6 interceptions so far this season. 

Why the San Francisco 49ers will win

San Francisco 49ers Player Prop Facts

Total Points Facts

49ers vs Bears Prediction

I’m on the 49ers here. I get that the Bears have played a ton of close games this season, good and bad, and they could easily do so here with them fighting for the division. However, the 49ers just keep finding ways to win by margin, winning their last five games by an average of 16.4 PPG. San Fran is just in playoff form right now, and they aren’t a team I’m trying to step in front of unless I have a good reason to. Give me San Francisco here.

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