49ers vs Titans Prediction 12/14/25 NFL Picks Today

The Tennessee Titans and the San Francisco 49ers meet in week 15 NFL action from Levi’s Stadium on Sunday. We will look at this from a betting perspective and determine the best bets for this game. Here’s a 49ers vs Titans Prediction.

Tennessee Titans Recap

The Tennessee Titans come into this game looking to add on to their 31-29 win over Cleveland last time out to sit at 2-11 this season. After this game, Tennessee will head home for a game against Kansas City.

Titans Snap Seven-Game Losing Streak

Cam Ward has thrown for 2,468 yards, 9 touchdowns and 7 interceptions on 59.1% passing while Tony Pollard has 743 rushing yards and 4 TDs to lead the Titans in rushing. Chig Okonkwo has a team-high 41 catches for 426 yards while Elic Ayomanor has 30 grabs for 353 yards and 3 TDs. Calvin Ridley has 303 receiving yards and Gunnar Helm has 298 receiving yards. Chimere Dike has 284 receiving yards with 3 TDs while two more Titans have 200+ receiving yards. On defense, Cedric Gray has a team-high 128 total tackles including 78 solo tackles while Jeffery Simmons has a team-high 8 sacks. Dre’Mont Jones and Jihad Ward each have 4.5 sacks apiece while Cody Barton has a team-high 3 interceptions. As a unit, Tennessee’s defense has combined for 32 sacks and 6 interceptions so far this season.

Why the Tennessee Titans will win

Tennessee Titans Player Prop Facts

San Francisco 49ers Recap

The San Francisco 49ers come into this game looking to add on to their 26-8 win over Cleveland last time out to sit at 9-4 this season. After this game, San Francisco will head on the road for a game against Indianapolis.

49ers Win 3 In A Row

Mac Jones has thrown for 2,151 yards, 13 touchdowns and 6 interceptions on 69.6% passing while Brock Purdy has thrown for 1,147 yards, 9 touchdowns and 7 interceptions on 66.3% passing. Christian McCaffrey has a team-high 849 rushing yards while also leading the 49ers in receiving with 85 grabs for 806 yards and 5 touchdowns. Ricky Pearsall has 347 receiving yards and 25 receptions while Kendrick Bourne has 482 receiving yards and Jauan Jennings has 458 receiving yards and 5 TDs. George Kittle also has 396 receiving yards and 37 catches along with 5 touchdowns this season. Three more 49ers have 150+ receiving yards and another pair have 150+ receiving yards as well on the year. On defense, Dee Winters has a team-high 84 total tackles. Bryce Huff and Clelin Ferrell each have a team-high 4 sacks. As a unit, San Francisco’s defense has combined for 16 sacks and 5 interceptions so far this season. 

Why the San Francisco 49ers will win

San Francisco 49ers Player Prop Facts

Total Points Facts

49ers vs Titans Prediction

I’m on San Francisco here. I think Tennessee got their win last time out, but I’m back to going against the Titans against a 49ers team off of a bye that’s been suffocating their opposition over the last month. Furthermore, I’m looking for the 49ers to completely shut down Tennessee and to win in another blowout. Give me the 49ers here.

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