The Detroit Lions and the Washington Commanders meet Sunday in NFL action from Northwest Stadium. Here’s a Commanders vs Lions prediction. We will look at this from a betting perspective and determine the best Commanders vs Lions pick.
Detroit Lions Betting Preview
Detroit kicked off their 2025 campaign with a loss to the rival Green Bay Packers but then got it going on a four-game win streak. Those victories came courtesy of the Chicago Bears, Baltimore Ravens, Cleveland Browns and Cincinnati Bengals. The Lions would then fall versus the Kansas City Chiefs before another win over the Buccaneers. In that game the Lions held Tampa Bay to just 251 total yards, 41 rush yards, 3.8 yards per play, 15 first downs and 4-of-16 on third-down tries alongside a couple of takeaways. Detroit’s offense had two turnovers and went just 3-of-13 on third-down tries, however.
In their latest outing versus the Minnesota Vikings on Sunday, the Lions were able to score points in every quarter—but also gave up points in every quarter—during a 27-24 defeat at home. QB Jared Goff logged a 25-of-37 line for 284 yards and a pair of scores. Leading rusher David Montgomery had 40 yards with a TD on 11 totes, and Amon-Ra St. Brown had nine receptions for 97 yards in the losing effort for the Lions.
Washington Commanders Betting Preview
Over on the Commanders’ side, they posted a 2-1 start with a loss to the Green Bay Packers in between wins over the New York Giants and Las Vegas Raiders. Washington posted a 1-4 run over the next five with a lone win over the Chargers mixed among losses to the Falcons, Bears, Cowboys and Chiefs. In the KC loss, the Commanders had a couple of picks but also gave up 26 first downs, 6.4 yards per play and 432 yards total. Washington’s offense posted just 60 rush yards and 14 first downs on the other side during the defeat.
Washington took on the Seahawks on Sunday evening. In that one the Commanders gave up a whopping 24 points in the second quarter alone and had little chance at mounting a comeback in an eventual blowout loss at home 38-14. QB Jayden Daniels logged a 16-of-22 line for 153 yards and a pick while also scoring a rush TD. Chris Rodriguez led the run on 12 carries for 65 yards and a score while Zach Ertz had four receptions for 46 yards in the defeat.
Detroit Lions @ Washington Commanders Betting Trends: Week 10
Why the Washington Commanders will win
- The underdogs have won four of the last five games between the Lions and Commanders.
- The Lions have lost 23 of their last 26 Week 10 road games against NFC opponents.
- The underdogs have covered the spread in each of the Commanders’ last four Week 10 games.
- The Lions have failed to cover the spread in five of their last six November games as favorites against NFC opponents.
- The Commanders have scored the first touchdown in four of their last five Week 10 home games.
- The Lions have lost the first quarter in each of their last four November games as road favorites against NFC opponents.
- The Commanders have won the first half in each of their last four November home games against the Lions.
Why the Detroit Lions will win
- The Lions have won each of their last 12 games as favorites following a loss.
- The Commanders have lost seven of their last eight games in November.
- The Lions have covered the spread in each of their last 12 games as favorites following a loss.
- The Commanders have failed to cover the spread in each of their last six games as underdogs following a home loss.
- The Lions have scored the first touchdown in each of their last eight games as favorites following a loss.
- The Commanders have lost the first quarter in each of their last eight games as underdogs against NFC opponents.
- The Lions have won the first half in each of their last 12 games as favorites following a loss.
Total Points Facts
- Seven of the Commanders’ last eight Sunday home games have gone OVER the total points line.
- Nine of the Lions’ last 11 Sunday games played on the East Coast have gone UNDER the total points line.
Washington Commanders Player Prop Facts
- Marcus Mariota has recorded 226+ passing yards in four of his five previous regular season appearances against NFC North opponents.
- Terry McLaurin has scored at least one touchdown in each of his last five Sunday appearances with the Commanders as underdogs.
- Jayden Daniels has recorded 44+ rushing yards in each of the Commanders’ last nine home games against NFC opponents.
- Deebo Samuel has recorded 59+ rushing and receiving yards in four of his five previous Week 10 appearances.
- Zach Ertz has recorded 36+ receiving yards in each of his last 11 November home appearances against NFC opponents.
- Jayden Daniels has recorded 22+ completions in seven of his last nine appearances with the Commanders as underdogs against NFC opponents.
- Jacory Croskey-Merritt has four rushing touchdowns through his first five career games – most by any player since De’Von Achane, (2023).
Detroit Lions Player Prop Facts
- Jared Goff has recorded 268+ passing yards in each of his last five appearances with his team as a favorite on the East Coast.
- Sam LaPorta has scored at least one touchdown in each of his last nine appearances with the Lions as favorites against teams on a losing streak.
- David Montgomery has recorded 53+ rushing yards in each of his last eight regular season appearances against NFC East opponents.
- David Montgomery has recorded 65+ rushing and receiving yards in each of his last eight regular season appearances against NFC East opponents.
- David Montgomery has scored the first touchdown in each of his last three regular season appearances with his team as a favorite against NFC East opponents.
- David Montgomery has recorded 12+ receiving yards in each of his seven previous November road appearances against NFC opponents.
- Jared Goff has recorded 23+ completions in eight of the Lions’ last nine games against NFC opponents.
- Heading into Week 10, Jared Goff has recorded the equal-most passing touchdowns in a single game this season (5 vs Bears, Week 2).
Matchup/League Facts
- Commanders – four different players have recorded 50+ rushing yards in a game this season – equal-most in the NFL, heading into Week 10.
- Commanders – four different players have recorded 60+ rushing yards in a game this season – most in the NFL, heading into Week 10.
- Lions – two different players have recorded 80+ rushing yards in a game this season – equal-most in the NFL, heading into Week 10.
- Lions – two different players have recorded 90+ rushing yards in a game this season – equal-most in the NFL, heading into Week 10.
Commanders vs Lions Prediction
I’ll stick with Detroit. The Lions have to get over a tough loss to the rival Vikings, though. In that one Detroit had issues with penalties, posting 10 for 76 yards. The offense ended up with just 15 first downs and 5-of-17 on third-down tries. Defensively Detroit gave up 258 yards, 4.4 yards per play, 20 first downs and 4-of-12 on third-down conversion attempts. The Lions have been scoring great lately with 24 or more points in six of their last seven games and overall they’ve been keeping other teams in check pretty well on the scoreboard.
As for Washington, they had two turnovers and eight penalties for 87 yards in their blowout loss to the Seahawks. The Commanders defense gave up 418 yards on the other side with 7-of-11 on third-down tries and 21 first downs. Washington has just 21 combined points over the last two games and they’ve given up 66 in that pair. This weekend’s going to be another tough matchup, and I don’t think the Commanders can keep any sort of relative pace. I like Detroit to control the game from front to back in this one and knock out a cover.