Blackhawks vs Sabres Prediction 11/21/25 NHL Picks Today

In this article, we will formulate a Blackhawks vs Sabres Prediction for this NHL game on Friday, November 21st. Let’s take a look at the prediction for this NHL matchup.

Buffalo Sabres Preview

The Sabres have 18 points this season with a 7-9-4 record, and are 8-12 ATS and 11-7 in over/under. They have a 6-4-2 home record and a 1-5-2 road record and are sitting 8th in the Atlantic Division. They are coming off a 6-2 home loss to the Flames and will face the Hurricanes and Penguins next.

Offensively, the Sabres are averaging 2.85 goals per game and are scoring 16.39% of their power play opportunities. Defensively, they are allowing 3.55 goals per game and are killing 89.83% of their opponent’s power plays.

Tage Thompson leads Buffalo with 18 points, 10 goals and 8 assists, while Alex Tuch follows with 16 points, 7 goals and 9 assists. Alex Lyon is the starting goalie for the Sabres, and he has a 3-5-4 record, with 3.07 GAA and .907 SV%. Colten Ellis is the backup goalie and he has a 3-2-0 record, with 3.41 GAA and .896 SV%.

Chicago Blackhawks Preview

The Blackhawks have 24 points this season with a 10-6-4 record, and are 16-4 ATS and 7-12 in over/under. They have a 5-3-2 home record and a 5-3-2 road record and are sitting 4th in the Central Division. They are coming off a 3-2 home loss to the Kraken and will face the Avalanche and Wild next.

Offensively, the Blackhawks are averaging 3.30 goals per game and are scoring 24.11% of their power play opportunities. Defensively, they are allowing 2.55 goals per game and are killing 83.61% of their opponent’s power plays.

Connor Bedard leads Chicago with 29 points, 13 goals and 16 assists, while Tyler Bertuzzi follows with 17 points, 10 goals and 7 assists. Spencer Knight is the starting goalie for the Blackhawks, and he has a 7-4-3 record, with 2.47 GAA and .922 SV%. Arvid Söderblom is the backup goalie and he has a 3-2-1 record, with 2.52 GAA and .912 SV%.

Chicago Blackhawks @ Buffalo Sabres Betting Trends: November 21, 2025

 

Why the Buffalo Sabres will win

Why the Chicago Blackhawks will win

Total Goals Facts

Buffalo Sabres Player Prop Facts

Chicago Blackhawks Player Prop Facts

Matchup/League Facts

Blackhawks vs Sabres Prediction

The Sabres are 7-1 in their last 8 meetings against the Blackhawks. In this Blackhawks vs Sabres Prediction, the Sabres are coming as -190 home favorites. The Sabres are being overvalued in this spot, as the Blackhawks are playing the second leg of a back-to-back. Chicago has been better both offensively and defensively than the Sabres, who are just 2-6 in their last 8 games and 1-3 in their last 4 at home. I will take a stab with the Blackhawks on the moneyline on the road for some nice plus money.

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