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Buffalo Bills vs. San Francisco 49ers - 10/16/16 NFL Pick, Odds, and Prediction

San Francisco 49ers (1-4) at Buffalo Bills (3-2)
Date & Time Sunday October 16, 2016, 1:00 PM (EDT)
The Line
The Line: Buffalo Bills -7.5 -- Over/Under: 44
TV Channel
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NFL | San Francisco 49ers (1-4) at Buffalo Bills (3-2)

The San Francisco 49ers and Buffalo Bills meet Sunday afternoon in a NFL showdown at New Era Field.

The San Francisco 49ers are desperate for a victory in hopes of snapping a rough four-game losing streak. The San Francisco 49ers have lost four straight road games overall. Colin Kaepernick will make his season debut at quarterback when he takes the field this week. Kaepernick has 244 pass attempts since the 2015 season and had six touchdown passes last year. Jeremy Kerley and Garrett Celek have combined for 439 receiving yards and two touchdowns while Quinton Patton has 12 receptions. The San Francisco 49ers ground game is averaging 121.4 yards per contest, and Carlos Hyde leads the way with 377 yards and six touchdowns. Defensively, San Francisco is allowing 28 points and 369.6 yards per game. NaVorro Bowman leads the San Francisco 49ers with 35 tackles, Ahmad Brooks has two sacks and Nick Bellore has one interception.

The Buffalo Bills hope to remain in the AFC playoff race after winning three straight games. The Buffalo Bills haven’t won four straight games since the 2008 season. Tyrod Taylor is completing 61.9 percent of his passes for 897 yards, six touchdowns and two interceptions. Taylor has one or less touchdown passes in five of his last seven games. Robert Woods and Charles Clay have combined for 383 receiving yards on 37 catches while Marquise Goodwin has six receptions. The Buffalo Bills ground game is averaging 137.2 yards per contest, and LeSean McCoy leads the way with 447 yards and three touchdowns. Defensively, Buffalo is allowing 17.4 points and 354.2 yards per game. Zach Brown leads the Buffalo Bills with 57 tackles, Lorenzo Alexander has seven sacks and Stephon Gilmore has two interceptions.

The 49ers are 0-4 ATS in their last 4 road games and 2-5 ATS in their last 7 games in October. The Bills are 5-1 ATS in their last 6 home games and 5-2 ATS in their last 7 games overall. The over is 5-2 in Bills last 7 home games and the over is 5-1 in 49ers last 6 road games.

The 49ers certainly give themselves a better chance to win or at the very least compete with Kaepernick on the field. The problem is Kaepernick hasn't been practicing much and is now being thrown into the fire on the road against a Buffalo Bills team that's feeling itself a bit after three straight victories. The Buffalo Bills all of a sudden have their eyes on the playoffs and are getting much more consistent play from their offense. It's also fair to mention that the 49ers have been waxed in their first two road games of the season. 

I'm not sure if I trust the Buffalo Bills just yet, but the San Francisco 49ers are who we thought they were and are just grasping at straws at this point. I'll take the Buffalo Bills to win this game at home by double digits.

Buffalo Bills -7.5

Randy Chambers has been with Sports Chat Place since 2014 and covers everything from the NFL to WNBA and tennis. Nobody works harder in this business in terms of content produced and amount of sports covered. Formerly a lead college football writer with Bleacher Report and has had his work featured at Fox Sports, CBS Sports and various other outlets.

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