Cincinnati Bengals at Buffalo Bills - 9/22/19 NFL Pick, Odds, and Prediction

Cincinnati Bengals at Buffalo Bills - 9/22/19 NFL Pick, Odds, and Prediction Photo by

Buffalo Bills vs. Cincinnati Bengals

Sunday, September 22, 2019 at 12:00 PM (New Era Field)

The Line: Buffalo Bills -6 -- Over/Under: 43.5 Click to Get Latest Betting Odds

TV: CBS Stream live sports and exclusive originals on ESPN+. Sign up now! Advertisement

The Cincinnati Bengals and Buffalo Bills meet Sunday in NFL action at New Era Field.

The Cincinnati Bengals need a win here to rebound from a rough 0-2 start to the season. The Cincinnati Bengals have lost their last six road games. Andy Dalton is completing 65.6 percent of his passes for 729 yards, four touchdowns and one interception. Dalton has two or more touchdown passes in each of his last six games. John Ross and Tyler Boyd have combined for 452 receiving yards and three touchdowns while C.J. Uzomah has four receptions. The Cincinnati Bengals ground game is averaging 29.5 yards per contest, and Joe Mixon leads the way with 27 yards on 17 carries. Defensively, Cincinnati is allowing 31 points and 401.5 yards per game. Preston Brown leads the Cincinnati Bengals with 18 tackles, Sam Hubbard has two sacks and William Jackson has one interception.

The Buffalo Bills look for another victory to get off to an improbable 3-0 start. The Buffalo Bills have split their last eight home games. Josh Allen is completing 64.2 percent of his passes for 507 yards, two touchdowns and two interceptions. Allen has one or less touchdown passes in 11 of his last 13 games. John Brown and Cole Beasley have combined for 318 receiving yards and one touchdown while Isaiah McKenzie has two receptions. The Buffalo Bills ground game is averaging 139.5 yards per contest, and Devin Singletary leads the way with 127 yards and one touchdown. Defensively, Buffalo is allowing 15 points and 296.5 yards per game. Tremaine Edmunds leads the Buffalo Bills with 16 tackles, Jerry Hughes has 1.5 sacks and Jordan Poyer has one interception.

Wonder who the Top Experts Picked? Click Here To Find Out

The Bengals are 5-0 ATS in their last 5 road games, 5-2 ATS in their last 7 games in September and 5-1 ATS in their last 6 games overall. The Bills are 5-2 ATS in their last 7 vs. AFC, 7-3 ATS in their last 10 games in September and 4-0 ATS in their last 4 games overall. The Bengals are 4-9 ATS in their last 13 meetings and the underdog is 6-2 ATS in their last 8 meetings. The under is 4-1 in Bills last 5 games overall. The under is 4-1-2 in Bengals last 7 games overall.

The Cincinnati Bengals have covered each of their last five games as a road underdog. The Buffalo Bills are 6-3-1 ATS in their last 10 games as a home favorite. We just saw the Bengals get smoked at home as a slight favorite against the 49ers, and they enter this game banged up on both sides of the ball, which includes tackle Andre Smith being questionable with a groin injury. The Buffalo Bills won back-to-back road games and now get to come home for the first time this season, playing in front of a nasty crowd. The Bills have their offensive line working early and the entire defense is making plays in the backfield. It feels weird laying nearly a full touchdown with the Bills, but that's where we're at this point in the season. Give me the Bills. 

See Who The Experts Picked To Win This One

Randy’s Pick Buffalo Bills -6

The pick in this article is the opinion of the writer, not a Sports Chat Place site consensus.

Mitch's Take...

Mitch's Dog of the Day 1/16/21: Free College Basketball Pick CBB Picks, Predictions and Betting Tip