Pittsburgh Steelers at San Francisco 49ers - 9/22/19 NFL Pick, Odds, and Prediction

Pittsburgh Steelers at San Francisco 49ers - 9/22/19 NFL Pick, Odds, and Prediction Photo by

San Francisco 49ers vs. Pittsburgh Steelers

Sunday, September 22, 2019 at 3:25 PM (Levi's Stadium)

The Line: San Francisco 49ers -6.5 -- Over/Under: 43

TV: CBS

The Pittsburgh Steelers and San Francisco 49ers meet Sunday in NFL action at Levi's Stadium.

The Pittsburgh Steelers need a victory here to rebound from a rough 0-2 start to the season. The Pittsburgh Steelers have lost four straight road games. Mason Rudolph is completing 63.2 percent of his passes for 112 yards, two touchdowns and one interception. Rudolph enters this game with 19 career pass attempts under his belt. JuJu Smith-Schuster and Vance McDonald have combined for 230 receiving yards and two touchdowns while James Washington has four receptions. The Pittsburgh Steelers ground game is averaging 56.5 yards per contest, and James Conner leads the way with 54 yards and one touchdown. Defensively, Pittsburgh is allowing 30.5 points and 445 yards per game. Devin Bush leads the Pittsburgh Steelers with 18 tackles, Stephon Tuitt has 2.5 sacks and Terrell Edmunds has one pass deflection.

The San Francisco 49ers look for another victory to start the season 3-0. The San Francisco 49ers have split their last eight home games. Jimmy Garoppolo is completing 67.3 percent of his passes for 462 yards, four touchdowns and two interceptions. Garoppolo has eight touchdown passes in his last four games. George Kittle and Deebo Samuel have combined for 211 receiving yards and one touchdown while Marquise Goodwin has four receptions. The San Francisco 49ers ground game is averaging 178.5 yards per contest, and Matt Breida leads the way with 158 yards on 27 carries. Defensively, San Francisco is allowing 17 points and 305.5 yards per game. Fred Warner leads the San Francisco 49ers with 16 tackles, Arik Armstead has two sacks and Richard Sherman has one interception.

The Steelers are 1-3-1 ATS in their last 5 road games, 1-6 ATS in their last 7 games in September and 2-6-1 ATS in their last 9 games overall. The 49ers are 7-16 ATS in their last 23 home games and 1-6 ATS in their last 7 games in Week 3. The favorite is 4-0 ATS in their last 4 meetings and the home team is 4-0 ATS in their last 4 meetings. The under is 7-3 in 49ers last 10 games on grass. The under is 36-15 in Steelers last 51 road games.

The Pittsburgh Steelers are 2-4-1 ATS in their last seven games as a road underdog of at least three points. The San Francisco 49ers have failed to cover each of their last seven games as a favorite of at least three points. It does feel like the sky is falling in Pittsburgh with the loss of Ben Roethlisberger and the 0-2 start. However, Rudolph is not a terrible backup option, and we know he's a gamer dating back to his days at Oklahoma State. The San Francisco 49ers haven't covered a home game when favored by at least three points since their 2014 win over the Kansas City Chiefs. Backup QB or not, the Steelers are still a talented group that can hang around, if not steal a game or two. Give me the points.

Randy’s Pick Pittsburgh Steelers +6.5

The pick in this article is the opinion of the writer, not a Sports Chat Place site consensus.