San Francisco 49ers vs. Pittsburgh Steelers - 9/22/19 NFL Pick, Odds, and Prediction

San Francisco 49ers vs. Pittsburgh Steelers - 9/22/19 NFL Pick, Odds, and Prediction Photo by

Pittsburgh Steelers vs. San Francisco 49ers

Sunday, September 22, 2019 at 3:25 PM (Levi's Stadium )

San Francisco 49ers -6 O/U: 45

TV: CBS

The Pittsburgh Steelers and the San Francisco 49ers will match up on the NFL Week 3 schedule Sunday.

Pittsburgh enters this game at 0-2 so far. The Steelers were embarrassed 33-3 by the Patriots in the opener then fell to the Seahawks 28-26 at Heinz in Week 2.

In the loss to Seattle, Steelers QB Mason Rudolph got most of the work with 112 yards, two touchdowns and a pick. JuJu Smith-Schuster was the leading Pittsburgh receiver with his 84 yards on five catches.

Over on the 49ers side, they’re riding high so far at 2-0. San Francisco took out the Buccaneers 31-17 in Week 1 then followed that up with a 41-17 drilling of the Bengals Week 2.

In the Week 2 win, San Fran QB Jimmy Garoppolo put up 297 yards, three scores and a pick, while Matt Breida had 121 rush yards. Deebo Samuel led the receivers there with 87 yards and a TD from five grabs.

The Steelers are 1-3-1 ATS in their last five road games and 2-6-1 ATS in their last nine overall. Pitt is 1-5-1 ATS in their last seven on grass and 1-6 ATS in their last seven in September.

Meanwhile, the Niners are 7-16 ATS in their last 23 home games and 1-6 ATS in their last seven in Week 3. San Francisco is 5-12 ATS in their last 17 home games versus a team with a losing road record and the over is 4-0 in their last four in Week 3.

With Ben Roethlisberger ailing, there’s a different dynamic to this game. The overall sentiment is still there, however: Pittsburgh really needs a win here. Considering the offensive onslaught San Fran has put together so far (against “meh” teams, granted, but Pitt qualifies as a “meh” team this year as well) I just don’t see it. I’ll take the 49ers, so long as the line is under a TD or so.

Andrew’s Pick San Francisco 49ers -6

The pick in this article is the opinion of the writer, not a Sports Chat Place site consensus.