Astros vs Angels Prediction 6/22/25 MLB Picks Today

The Houston Astros are visiting the Los Angeles Angels on Sunday, June 22nd at the Angel Stadium in the second game of this series, with both teams being tied 1-1 wins. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Astros vs Angels Prediction. We will examine:

The Los Angeles Angels recent form and player performance

The Houston Astros recent form and player performance

Recent betting trends and streaks involving the Los Angeles Angels

Recent betting trends and streaks involving the Houston Astros

Recent betting trends in games played between the Houston Astros vs Los Angeles Angels

A summary that ties it all together and produces a favorable betting outcome for the Houston Astros vs Los Angeles Angels game

Los Angeles Angels Preview

The Los Angeles Angels have a 37-39 record this season and are sitting on the 4th place of the AL West. The Angels have a 16-17 home record and 39-36 in over/under They are coming off a 9-1 home victory over the Astros, which snapped their previous two-game losing streak. Under is 5-1 in their last 6 games and are playing the Red Sox and the Nationals next.

The Angels have a .225 batting average this season, .288 OBP and .401 Slugging percentage. LA’s pitching staff has a 4.58 ERA and 1.46 WHIP. Nolan Schanuel leads the Angels with 74 hits and he is the team’s best hitter with a .277 batting average. Taylor Ward leads the team with 52 RBI and a team-high 19 home runs.

Kyle Hendricks (R) will take the mound for the Angels, and he has a 5-6 record, 4.79 ERA and 1.29 WHIP. He has been better at home with a 4.04 ERA across six home starts, and he is coming off a shutout start in 6 innings pitched against the Yankees. In his previous start against the Astros this season, he gave up 5 runs across 4 innings of work, as the Angels lost 3-7.

Houston Astros Preview

The Houston Astros have a 44-33 record this season and are sitting on the first place of the AL West. The Astros have a 17-20 road record and 32-42 in over/under. They are coming off a 1-9 road defeat by the Angels, but still are are 8-3 in their last 11 games. Over is 4-1 in their last 5 games, and they are playing the Cubs and the Phillies next.

The Astros have a .256 batting average this season, .322 OBP and .399 slugging percentage. Houston’s pitching staff has a 3.48 ERA and 1.15 WHIP. Jeremy Pena leads the Astros with 97 hits and he is the team’s best hitter, with a .324 batting average. Isaac Paredes leads the team in RBI with 45, adding a team-high 16 home runs.

Ryan Gusto (R) is the projected starter for the Astros, and he has a 4-3 record, 4.31 ERA and 1.53 WHIP. He has been better on the road, with a 2.40 ERA across 6 road games, and he is coming off a quality start against the Athletics, where he gave up one runs across 5 innings of work. In his previous start against the Angels this season, he gave up 3 runs in 4 innings of work, as the Astros lost 1-4.

Why the Los Angeles Angels will win

Why the Houston Astros will win

Total Runs Facts

Matchup/League Facts

Houston Astros vs Los Angeles Angels 6/22/25 MLB Pick & Prediction | MLB Betting Tips

Astros vs Angels Prediction

The Astros are 9-3 in their last 12 overall meetings against the Angels, and are 4-1 in their last 5 visits in Los Angeles. Over is 6-2 in their last 8 meetings.

In this Astros vs Angels Prediction, the Astros are coming as -135 road favorites. The Astros are rightfully favored, as they have a better overall record, but both teams have similar home/away splits. The Angels have the 4th-worst bullpen in the league and I don’t trust any of those pitchers, as they have a combined 9.10 ERA, and in their previous start against the other team this season, they got hit, with 3 and 5 earned runs respectively. In a hitter-friendly park, I expect a high-scoring game, so take the over 9 runs in this one.

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