Astros vs Padres Prediction 4/20/25 MLB Picks Today

In this article we will formulate an Astros vs Padres prediction for this MLB game on Sunday, April 20th at Daikin Park in Houston, Texas. Let’s take a look at the prediction for this MLB matchup. 

Houston Astros Betting Preview

The Houston Astros are 10-10 this season and they have won the first two games in this series by scores of 6-4 and 3-2. In their game two win, the Astros trailed 2-0 in the fifth inning, but they scored the last three runs in the game for the win. The Astros recorded seven hits in the game and they were led by Walker, who went 1-4 with one home run and two RBIs in the win. Houston started Wesneski, who allowed six hits and two earned runs over 5.0 innings, while Hader picked up the save in the ninth. 

Prior to this series, the Astros lost two out of three against the Cardinals, but did win two out of three against the Angels before that. Houston has won three of their last four games and they are currently third in the AL West standings. The Houston pitching staff has a 3.66 ERA with a 1.14 WHIP and a .214 opponent batting average, while their offense has scored 75 runs with a .223 batting average and a .303 on base percentage this season. Isaac Paredes has led Houston with three home runs and 11 RBIs, while Yordan Alvarez has added two home runs, 10 RBIs, and one stolen base this year. The projected starting pitcher for Houston is Framber Valdez, who is 1-2 with a 4.91 ERA and a 1.27 WHIP over 22.0 innings pitched this season. 

San Diego Padres Betting Preview

The San Diego Padres are 15-6 this year after they lost game two in this series by a score of 3-2 on Saturday. San Diego jumped out to a 1-0 lead in the third inning and they added another in the fifth, before the pitching staff had some issues with walks and allowed three runs. The Padres recorded seven hits in the game and they were led by Tatis Jr., who went 2-4 with one home run and one RBI in the loss. San Diego started King, who allowed four hits and two earned runs over 5.2 innings, while Estrada allowed two hits and one earned run over 1.1 innings for the loss. 

Prior to this series, the Padres won two out of three against the Cubs and swept the Rockies in three games. San Diego has lost three of their last four games and they are currently first in the NL West standings. The San Diego pitching staff has a 2.77 ERA with a 1.10 WHIP and a .203 opponent batting average, while their offense has scored 94 runs with a .275 batting average and a .344 on base percentage this season. Fernando Tatis has led San Diego with seven home runs and 15 RBIs, while Gavin Sheets has added two home runs and 10 RBIs this year. The projected starting pitcher for San Diego is Dylan Cease, who is 1-1 with a 6.64 ERA and a 1.52 WHIP over 20.1 innings pitched this year.

Why the Astros will beat the Padres

Why the Padres will beat the Astros

Total Runs Facts

Houston Astros Player Prop Facts

San Diego Padres Player Prop Facts

Matchup/League Facts

Astros vs Padres Prediction 

Houston was finally able to win back to back games for the first time this season on Saturday and they will go for the sweep here. The Astros are 6-5 at home this year, while the Padres are just 3-5 on the road. Houston is starting Valdez, who has allowed five earned runs or more in two of his last three starts. San Diego is going with Cease, who has pitched well for the most part, but did allow nine earned runs two starts ago. I think we are going to see some offense in this game and I don’t trust Valdez at all, so give me the over here. 

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