Giants vs Padres Prediction 8/20/25 MLB Picks Today

In this article, we will formulate a Giants vs Padres Prediction for this MLB game on Wednesday, August 20th at the Petco Park in the third game of this series, with both teams being tied 1-1 wins. Let’s take a look at the prediction for this MLB matchup.

San Diego Padres Preview

The San Diego Padres have a 70-56 record this season and are sitting on the second place of the NL West. They have a 39-21 home record, and are 51-71 in over/under. The Padres are coming off a 5-1 home victory over the Giants, which ended their four-game losing streak. Under is 6-1-1 in their last 8 games and are playing the Dodgers and the Mariners next.

The Padres have a .251 batting average this season, .322 OBP and .382 Slugging percentage. San Diego’s pitching staff has a 3.55 ERA and 1.20 WHIP. Luis Arraez leads the Padres with 142 hits and team-high .292 batting average. Manny Machado leads the team in RBI, with 73, adding a team-high 20 home runs.

JP Sears (L) is the projected starting pitcher for the Padres, and he has a 7-10 record, 5.12 ERA and 1.31 WHIP.

San Francisco Giants Preview

The San Francisco Giants have a 61-65 record this season and are sitting on the third place of the NL West. They have a 31-32 road record and are 57-64 in over/under. They are coming off a 1-5 home defeat by the Padres, that ended their two-game winning streak. Under is 8-3-1 in their last 12 games and are playing the Cubs and the Brewers next.

The Giants have a .232 batting average this season, .309 OBP and .375 Slugging percentage. San Francisco’s pitching staff has a 3.68 ERA and 1.28 WHIP.  Heliot Ramos leads the Giants with 128 hits and is the team’s best hitter, with a .265 batting average. Wilmer Flores leads the team in RBI with 63, while Willy Adames adds a team-high 19 home runs.

Landen Roupp (R) is the projected starting pitcher for the Giants, and he has a 7-6 record, 3.45 ERA and 1.45 WHIP.

Why the San Diego Padres will win

Why the San Francisco Giants will win

Total Runs Facts

Matchup/League Facts

Giants vs Padres Prediction

The Padres are 9-3 in their last 12 meetings against the Giants, and are 3-1 in their last 4 visits in San Diego. Under is 7-2 in their last 9 meetings.

In this Giants vs Padres Prediction, the Padres are coming as -160 home favorites. I don’t trust either pitcher, as Sears has only played one game for the Padres before going to the IL, and he was torched for 5 earned runs. He has also been weaker at home this season, with a 5.48 home ERA, while Roupp has been also weaker on the road for the Giants, with a 4.15 road ERA. Roupp had three straight quality starts before getting torched by the Rays in his last start, and his previous start against the Padres this season was a shutout. I don’t love it, but I like the chances with the Giants as road dogs in this one. Lean towards the San Francisco Giants and the plus money in this one.

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