Guardians vs Twins Prediction 4/29/25 MLB Picks Today

In this article, we will formulate a Guardians vs Twins prediction for this MLB game on Tuesday, April 29th at Progressive Field in Cleveland, Ohio. Let’s take a look at the prediction for this MLB matchup. 

Cleveland Guardians Betting Preview

The Cleveland Guardians are 15-13 this season after they lost game one in this series by a score of 11-1 on Monday night. Cleveland allowed the first six runs in the game, and they never had a chance in this one. The Guardians recorded eight hits in the game, and they were led by Noel, who went 1-4 with one RBI in the loss. Cleveland started Williams, who allowed seven hits and four earned runs over 2.0 innings in the loss, while Herrin, Bolton, and Wilson all allowed at least two earned runs in relief. 

Prior to this series, the Guardians lost two out of three against the Red Sox, but did win two out of three against the Yankees before that. Cleveland has lost four of their last five games, and they are currently second in the AL Central standings. The Cleveland pitching staff has a 4.61 ERA with a 1.46 WHIP and a .263 opponent batting average, while the offense has scored 108 runs with a .237 batting average and a .306 on-base percentage this season. Kyle Manzardo has led Cleveland with seven home runs and 18 RBIs, while Steven Kwan has added four home runs and 15 RBIs this year. The projected starting pitcher for Cleveland is Tanner Bibee, who is 2-2 with a 5.19 ERA and a 1.46 WHIP over 26.0 innings pitched this season. 

Minnesota Twins Betting Preview

The Minnesota Twins are 13-16 this year after they won game one in this series on Monday night. Minnesota scored four runs in the first two innings and piled on the runs in the fifth and sixth innings for the blowout win. The Twins recorded 17 hits in the game, and they were led by Jeffers, who went 2-4 with one home run, three RBIs, and one walk in the win. Minnesota started Ober, who allowed eight hits and one earned run over 7.2 innings in the win, while Alcala finished the last 1.1 innings. 

Prior to this series, the Twins won all three against the Angels and two out of three against the White Sox. Minnesota has won six of its last seven games, and they are currently fourth in the AL Central standings. The Minnesota pitching staff has a 3.55 ERA with a 1.21 WHIP and a .238 opponent batting average, while their offense has scored 117 runs with a .234 batting average and a .310 on-base percentage this season. Byron Buxton has led Minnesota with six home runs and 17 RBIs, while Harrison Bader has added three home runs and 13 RBIs this year. The projected starting pitcher for Minnesota is Chris Paddack, who is 0-3 with a 6.45 ERA and a 1.61 WHIP over 22.1 innings pitched this season. 

Why the Guardians will beat the Twins

Why the Twins will beat the Guardians

Total Runs Facts

Cleveland Guardians Player Prop Facts

Minnesota Twins Player Prop Facts

Guardians vs Twins Prediction 

Minnesota was able to start this series with a blowout victory on Monday night, and they have played very well over the last week. The Twins are just 4-10 on the road this year, while the Guardians are 8-5 at home. Cleveland has lost three games in a row, and they have allowed 31 runs in those three games. The Guardians will send Bibee to the mound, who has allowed six earned runs or more in two of his last four starts. The Twins are going with Paddack, who has allowed two earned runs or fewer in three straight. Both of these pitchers have allowed plenty of baserunners this year, and I think we will see plenty of runs, so take the over here. 

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