Padres vs Cubs Prediction 4/16/25 MLB Picks Today

The Chicago Cubs and San Diego Padres meet Wednesday in MLB action at Petco Park. Here’s a Padres vs Cubs Prediction. This article will include a Padres vs Cubs Pick.

Chicago Cubs Betting Preview

The Chicago Cubs are 12-8 on the year and play the Diamondbacks, Dodgers, and Phillies next. The Chicago Cubs are batting .257 on the season, have a .345 OBP, and a .436 slugging percentage. The Chicago Cubs pitching staff has a 4.12 ERA and a 1.36 WHIP. Kyle Tucker leads the Chicago Cubs with 25 hits and 18 RBI, while Nico Hoerner and Pete Crow-Armstrong have combined for 41 hits and 20 RBI.

Matthew Boyd gets the ball for the Chicago Cubs, and he is 1-1 with a 1.59 ERA and 17 strikeouts this season. This will be Boyd’s second career game against the San Diego Padres.

San Diego Padres Betting Preview

The San Diego Padres are 14-4 on the year and play the Astros, Tigers, and Rays next. The San Diego Padres are batting .277 on the season, have a .346 OBP, and a .425 slugging percentage. The San Diego Padres pitching staff has a 2.59 ERA and a 1.09 WHIP. Fernando Tatis Jr. leads the San Diego Padres with 23 hits and 12 RBI, while Luis Arraez and Manny Machado have combined for 42 hits and 12 RBI.

Nick Pivetta gets the ball for the San Diego Padres, and he is 2-1 with a 1.59 ERA and 18 strikeouts this season. Pivetta is 1-2 with a 4.74 ERA and 23 strikeouts in his career against the Chicago Cubs.

Why the San Diego Padres will win

Why the Chicago Cubs will win

Matchup/League Facts

  • The Padres rank 2nd in the league for batting average this season (.277).
  • The Padres rank 2nd in the league for ERA this season (2.59).
  • The Cubs rank 1st in the league for runs scored this season (122).
  • The Cubs rank 1st in the league for hits this season (182).

Padres vs Cubs Prediction

The Cubs have been a scrappy bunch through 20 games, and they’re going to be a team to watch. Boyd has also been strong this season, allowing 13 hits and three runs through 17 innings. However, the Padres have been arguably the most impressive team in baseball up to this point, and they’re not a team I’m excited to bet against. Pivetta has above-average stuff, and he’s allowed just three runs in 17 innings while striking out 18. I’m going to keep siding with the Padres as long as the tickets keep cashing.

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