Pirates vs Cardinals Prediction 4/28/26 MLB Picks Today

In this article we will formulate a Pirates vs Cardinals prediction for this MLB game on Tuesday, April 28th at PNC Park in Pittsburgh, Pennsylvania. Let’s take a look at the prediction for this MLB matchup. 

Pittsburgh Pirates Betting Preview

The Pittsburgh Pirates are 16-13 this year after they lost game one by a score of 4-2 on Monday night. Pittsburgh led 2-0 for almost the whole game, but they allowed four runs in the ninth for the loss. The Pirates recorded eight hits in the game and they were led by Mangum and O’Hearn, who both had one RBI. Dotel allowed zero hits and zero earned runs over 4.0 innings, while Santana blew the save and got the loss. Prior to this series, Pittsburgh won two out of three against the Brewers, but lost two out of three against the Rangers before that. 

This season, Pittsburgh has a 3.36 ERA with a 1.22 WHIP and a .218 opponent batting average, while they have scored 137 runs with a .241 batting average and a .324 on base percentage. Oneil Cruz has led the Pirates with eight home runs and 24 RBIs, while Brandon Lowe has added seven home runs and 19 RBIs. The projected starting pitcher for Pittsburgh is Bubba Chandler, who is 1-2 with a 4.88 ERA and a 1.50 WHIP over 24.0 innings pitched this year. 

St. Louis Cardinals Betting Preview

The St. Louis Cardinals are 15-13 this season after they won game one in dramatic fashion last night. St. Louis really struggled at the plate in the first eight innings, but they found life in the ninth to get the win. The Cardinals recorded six hits in the game and they were led by Fermin, who went 2-2 with two RBIs. May allowed seven hits and two earned runs over 6.0 innings, while Fernandez got the win and Soriano picked up the save. Prior to this series, St. Louis lost all three against the Mariners and two out of three against the Marlins. 

This season, St. Louis has a 4.77 ERA with a 1.42 WHIP and a .260 opponent batting average, while they have scored 129 runs with a .234 batting average and a .321 on base percentage. Jordan Walker has led the Cardinals with eight home runs and 16 RBIs, while Alec Burleson has added three home runs and 17 RBIs. The projected starting pitcher for St. Louis is Kyle Leahy, who is 2-3 with a 5.63 ERA and a 1.67 WHIP over 24.0 innings pitched this season.

Why the Pittsburgh Pirates will win

Why the St. Louis Cardinals will win

Total Runs Facts

Pittsburgh Pirates Player Prop Facts

St. Louis Cardinals Player Prop Facts

Pirates vs Cardinals Prediction 

St. Louis snapped their losing streak with a win on Monday night, but they have scored two runs or fewer in three of their last five games. The Cardinals are 8-5 on the road this year, while the Pirates are 8-6 at home. Pittsburgh has split their last four games, but they have scored two runs or fewer in three of their last five. St. Louis is starting Leahy, who has allowed seven earned runs and 13 hits in his last 10.0 innings, so I will take the Pirates -1.5 in this one. 

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