White Sox vs Cardinals Prediction 6/17/25 MLB Picks Today

The St. Louis Cardinals and Chicago White Sox meet Tuesday in MLB action at Rate Field. Here’s a White Sox vs Cardinals Prediction. This article will include a White Sox vs Cardinals Pick.

St. Louis Cardinals Betting Preview

The St. Louis Cardinals are 37-35 on the year and play the Reds, Cubs, and Guardians next. The St. Louis Cardinals are batting .255 on the season, have a .326 OBP, and a .391 slugging percentage. The St. Louis Cardinals’ pitching staff has a 3.99 ERA and a 1.28 WHIP. Brendan Donovan leads the St. Louis Cardinals with 79 hits and 26 RBI, while Willson Contreras and Nolan Arenado have combined for 126 hits and 81 RBI.

Matthew Liberatore gets the ball for the St. Louis Cardinals, and he is 3-6 with a 4.17 ERA and 62 strikeouts this season. This will be Liberatore’s second career game against the Chicago White Sox.

Chicago White Sox Betting Preview

The Chicago White Sox are 23-49 on the year and play the Blue Jays, Diamondbacks, and Giants next. The Chicago White Sox are batting .222 on the season, have a .295 OBP, and a .343 slugging percentage. The Chicago White Sox pitching staff has a 4.13 ERA and a 1.40 WHIP. Miguel Vargas leads the Chicago White Sox with 61 hits and 31 RBI, while Lenyn Sosa and Chase Meidroth have combined for 105 hits and 26 RBI.

Shane Smith gets the ball for the St. Louis Cardinals, and he is 3-3 with a 2.37 ERA and 64 strikeouts this season. This will be Smith’s first career game against the St. Louis Cardinals.

Why the Chicago White Sox will win

Why the St. Louis Cardinals will win

Chicago White Sox Player Prop Facts

St. Louis Cardinals Player Prop Facts

White Sox vs Cardinals Prediction

The White Sox are a team I’ve faded a lot over the years, and I don’t have much interest in them this season. However, the Cardinals are riding an ugly losing streak. Liberatore has been hitable with a 4.17 ERA on the season. Liberatore has a 4.45 ERA and .271 allowed batting average in 32.1 road innings. While the White Sox have issues, obviously, Smith has been a bright spot with a 2.37 ERA and 1.17 WHIP. In 33 home innings, Smith has a 2.18 ERA and a .190 allowed batting average. I don’t do this often, but give me the White Sox because of the starting pitching edge and the Cardinals’ terrible form.

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