Reds vs Cubs Prediction 5/25/25 MLB Picks Today
Chicago Cubs (31-21) vs. Cincinnati Reds (26-27)
May 25, 2025 1:40 pm EDT
The Line: Cincinnati Reds -102 / Chicago Cubs -118; Over/Under: 9
(Get latest betting odds)
The Chicago Cubs and Cincinnati Reds meet Sunday in MLB action at Great American Ball Park. Here’s a Reds vs Cubs Prediction. This article will include a Reds vs Cubs Pick.
Chicago Cubs Betting Preview
The Chicago Cubs are 31-21 on the year and play the Rockies, Reds, and Nationals next. The Chicago Cubs are batting .263 on the season, have a .336 OBP, and a .456 slugging percentage. The Chicago Cubs pitching staff has a 3.99 ERA and a 1.30 WHIP. Pete Crow-Armstrong leads the Chicago Cubs with 58 hits and 46 RBI, while Kyle Tucker and Nico Hoerner have combined for 113 hits and 59 RBI.
Ben Brown gets the ball for the Chicago Cubs, and he is 3-3 with a 5.44 ERA and 58 strikeouts this season. Brown is 0-2 with an 8.00 ERA and 9 strikeouts in his career against the Cincinnati Reds.
Cincinnati Reds Betting Preview
The Cincinnati Reds are 26-27 on the year and play the Royals, Cubs, and Brewers next. The Cincinnati Reds are batting .244 on the season, have a .320 OBP, and a .394 slugging percentage. The Cincinnati Reds pitching staff has a 3.68 ERA and a 1.19 WHIP. TJ Friedl leads the Cincinnati Reds with 53 hits and 19 RBI, while Elly De La Cruz and Gavin Lux have combined for 97 hits and 57 RBI.
Nick Lodolo gets the ball for the Cincinnati Reds, and he is 4-4 with a 3.22 ERA and 49 strikeouts this season. Lodolo is 2-2 with a 5.27 ERA and 27 strikeouts in his career against the Chicago Cubs.
Why the Cincinnati Reds will win
- The Reds have won four of their last five games as underdogs after playing the previous day.
- The Cubs have lost each of their last five Sunday games as favorites against National League opponents.
- The Reds have covered the run line in nine of their last 10 games as home underdogs against NL Central opponents.
- The Cubs have failed to cover the run line in each of their last five day games against National League opponents.
- The Reds have won the first inning in each of their last three games as underdogs against the Cubs at Great American Ball Park.
- The Reds have led after 5 innings in seven of their last eight games against opponents that held a winning record.
- The Reds have led after 3 innings in nine of their last 10 games as home underdogs against NL Central opponents.
Why the Chicago Cubs will win
- The Cubs have won each of their last 13 games following a road loss.
- The Reds have lost nine of their last 11 day games against NL Central opponents following a win.
- The Reds have failed to cover the run line in 12 of their last 13 day games against the Cubs at Great American Ball Park following a win.
- The Cubs have covered the run line in each of their last six games following a road loss.
- The Cubs have led after 3 innings in seven of their last eight Sunday day games as favorites.
Cincinnati Reds Player Prop Facts
- Nick Lodolo has recorded six or more strikeouts in eight of his last nine appearances with the Reds as home underdogs.
- Spencer Steer has recorded an RBI in each of the Reds’ last four games as underdogs against NL Central opponents.
- Spencer Steer has recorded at least one hit in each of the Reds’ last 13 home games.
- Santiago Espinal has scored at least one run in each of the Reds’ last five home games against the Cubs.
- Nick Lodolo has recorded a win in three of his last four home appearances against NL Central opponents.
- Will Benson has hit at least one home run in four of his last six appearances after playing the previous day.
- Gavin Lux has recorded at least one Double in four of his last five appearances after playing the previous day.
- Spencer Steer has recorded at least one Single in each of the Reds’ last seven games.
Chicago Cubs Player Prop Facts
- Carson Kelly has scored at least one run in eight of his last nine appearances with the Cubs as road favorites.
- Kyle Tucker has hit a home run in five of his last seven appearances in day games against NL teams that held a losing record.
- Seiya Suzuki has recorded at least one Double in each of the Cubs’ last three games at Great American Ball Park against opponents that held a losing record.
- Carson Kelly has recorded at least one Single in each of his last nine appearances with his team as a road favorite against NL opponents.
- Kyle Tucker has recorded at least one RBI in eight of his 10 previous road appearances against NL Central opponents that held a losing record.
- Ian Happ has recorded at least one hit in each of the Cubs’ last 12 road games against NL Central opponents
Reds vs Cubs Prediction
The Reds have found their form over the last couple of weeks, and they should be excited about facing Brown, who has a 5.44 ERA and 1.55 WHIP. In his last 21 innings, Brown has allowed 22 hits and 11 runs. While he’s been rocked at home this season, Lodolo has been more consistent overall, with his 3.22 ERA and 1.06 WHIP. Lodolo is averaging a strikeout per inning in his last 22.2 innings. Toss-up line, give me the Reds at home with the more trustworthy pitcher.

