Orioles vs Cardinals Prediction 5/28/25 MLB Picks Today

The St. Louis Cardinals and the Baltimore Orioles meet Wednesday in MLB action from Camden Yards. We will look at this from a betting perspective and determine the best bets for this game. Here’s an Orioles vs Cardinals Prediction.

Starting Pitching Matchup

The St. Louis Cardinals will send out Miles Mikolas for the start here, and Mikolas is 4-2 with a 3.51 ERA and 31 strikeouts this season. In his career, Mikolas is 1-0 with a 2.92 ERA and 7 strikeouts against Baltimore. Cade Povich will get the nod for the Orioles here and is 1-3 with a 4.86 ERA and 44 strikeouts this season. This will be Povich’s first career start against the Cardinals.

St. Louis Cardinals Recap

The St. Louis Cardinals come into this game looking to build on their 7-4 win over the Orioles from Tuesday’s matchup to improve to 31-24 on the year. After this series, the Cardinals will head on the road for a series against the Texas Rangers.

Cardinals Get Back On Track

Brendan Donovan has a team-high 66 hits along with 18 doubles, 3 home runs, and 22 RBIs, while Lars Nootbaar has 49 hits with 7 home runs, 25 RBIs, and 4 stolen bases. Nolan Arenado also has 44 hits with 10 doubles, 5 home runs, and 25 RBIs of his own, and Victor Scott II has 44 hits with 8 doubles, a triple, 19 RBIs, and a team-high 16 stolen bases. Willson Contreras has also chipped in 46 hits with 6 home runs and 28 RBIs of his own this season.

Why the St. Louis Cardinals will win

St. Louis Cardinals Player Prop Facts

Baltimore Orioles Recap

The Baltimore Orioles come into this game looking to rebound from their loss at the hands of the Cardinals in Tuesday’s matchup to drop to 19-35 this season. After this series, the Orioles will take on the Chicago White Sox at home.

Orioles Have Three-Game Win Streak Snapped

Cedric Mullins has 40 hits so far this season as well as 9 doubles, 10 home runs, and 31 RBIs with 7 stolen bases and a .226 batting average, while Adley Rutschman has 37 hits with 7 doubles, 5 homers, and 15 RBIs. Jackson Holliday has 46 hits with 5 doubles, 2 triples, 6 homers, and 23 RBIs. Ryan Mountcastle has 39 hits with 10 doubles, 2 homers, and 15 RBIs, and Gunnar Henderson has a team-high 56 strikeouts as well this season. Ryan O’Hearn also chipped in 52 hits with 7 doubles and 8 home runs with 18 RBIs, and Heston Kjerstad added 4 homers and 15 RBIs.

Why the Baltimore Orioles will win

Baltimore Orioles Player Prop Facts

Total Runs Facts

Orioles vs Cardinals Prediction

I’m on St. Louis here. I just think that sustained success and the Orioles aren’t going to be something to expect this season. Has Cade Povich had a couple of nice starts? Yes, but he still has an ERA just under five this season, and is a part of Baltimore’s starting pitching rotation is still top-3 in the highest rotation ERAs this season. Baltimore’s bullpen also has a 14.23 ERA in the last week as well, so no lead is safe. Mikolas has been in an impressive run of form, and I think he gets the job done here for St. Louis.

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