College Football

Missouri vs Vanderbilt Prediction 9-21-24 College Football Picks

Vanderbilt Commodores (2-1) vs. Missouri Tigers (3-0)
September 21, 2024 4:15 pm EDT
The Line: Missouri Tigers -21 / Vanderbilt Commodores +21; Over/Under: +53.5
(Get latest betting odds)

The Vanderbilt Commodores and the Missouri Tigers meet Saturday in college football action from Faurot Field. Here’s a Missouri vs Vanderbilt prediction. We will look at this from a betting perspective and determine the best Missouri vs Vanderbilt pick.

Vanderbilt Commodores Betting Preview

Vanderbilt’s season kicked off with a matchup versus Virginia Tech. It took overtime to get there, but the Commodores would come away with a 34-27 win. Game two versus Alcorn State was significantly easier. Vanderbilt posted a 55-0 blowout win in that one.


Last weekend versus Georgia State, the Commodores scored a blistering 22 points in the final quarter but it wasn’t enough in a 36-32 loss. Diego Pavia threw for 270 yards and two touchdowns. Leading the rush was Sedrick Alexander with 42 yards and a TD.

Missouri Tigers Betting Preview

Over on the Tigers’ side, they posted a couple of dominant blowout wins in their first pair of games. The opener was a 51-0 shutout against Murray State. Missouri kept it rolling the next weekend, easily dispatching Buffalo 38-0 in another blowout.

In game three versus Boston College, the Tigers had a pretty dramatic battle. Missouri held a slim 17-14 lead after the first half and ultimately eked out the win 27-21. QB Brady Cook logged 264 yards and a TD while Nate Noel led the rush on 22 carries for 121 yards.

Why the Missouri Tigers will win

  • Vanderbilt has lost each of its last 16 games against AP-ranked teams.
  • Missouri has won each of its last nine games against non-AP-ranked teams.
  • Vanderbilt has failed to cover the spread in seven of its last eight games in September.
  • Missouri has covered the spread in six of its last seven games against non-AP-ranked teams.
  • Vanderbilt has lost the first half in each of its last nine games against conference opponents.

Why the Vanderbilt Commodores will win

  • Vanderbilt has covered the spread in four of its last five September games as a road underdog against top-15 AP-ranked teams.

Total Points Facts

  • Each of Vanderbilt’s last seven games in September has gone OVER the total points line.
  • Each of Missouri’s last four games has gone UNDER the total points line.

Missouri vs Vanderbilt Prediction

I’ll stick with Missouri. The Tigers were barely able to fend off a plucky Boston College team last weekend despite posting 440 total yards (264 passing), 22 first downs, and a nice 11-of-19 rate on third downs. Missouri’s eight penalties for 91 yards didn’t help, but otherwise, the team looked pretty good statistically overall.

As for Vanderbilt, they’re coming off a tough loss themselves despite a late push. The Commodores finished with 380 yards of offense (270 passing) but gave up 426 yards (269 passing) on the other side. This weekend’s matchup will be even tougher.

Andrew's Free Pick: Missouri Tigers -21

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Andrew

Andrew has been writing about college, professional and fantasy sports betting since 2013. Andrew's goal is to break down the complicated numbers and trends into a language that's easily accessible to novice sports bettors and seasoned professionals alike.

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