Astros vs Blue Jays Prediction 4/21/25 MLB Picks Today

The Toronto Blue Jays and Houston Astros meet Monday in MLB action at Daikin Park. Here’s an Astros vs Blue Jays Prediction. This article will include an Astros vs Blue Jays Pick.

Toronto Blue Jays Betting Preview

The Toronto Blue Jays are 12-10 on the year and play the Yankees, Red Sox, and Guardians next. The Toronto Blue Jays are batting .259 on the season, have a .333 OBP, and a .368 slugging percentage. The Toronto Blue Jays’ pitching staff has a 3.58 ERA and a 1.11 WHIP. Bo Bichette leads the Toronto Blue Jays with 30 hits and 13 RBI, while Vladimir Guerrero Jr. and George Springer have combined for 46 hits and 21 RBI.

Kevin Gausman gets the ball for the Toronto Blue Jays, and he is 2-1 with a 2.49 ERA and 20 strikeouts this season. Gausman is 3-4 with a 5.01 ERA and 54 strikeouts in his career against the Houston Astros.

Houston Astros Betting Preview

The Houston Astros are 10-11 on the year and play the Royals, Tigers, and White Sox next. The Houston Astros are batting .222 on the season, have a .299 OBP, and a .331 slugging percentage. The Houston Astros’ pitching staff has a 3.63 ERA and a 1.16 WHIP. Jose Altuve leads the Houston Astros with 26 hits and 7 RBI, while Jake Meyers and Isaac Paredes have combined for 36 hits and 16 RBI.

Hunter Brown gets the ball for the Houston Astros, and he is 2-1 with a 1.50 ERA and 22 strikeouts this season. Brown is 1-1 with a 2.45 ERA and 10 strikeouts in his career against the Toronto Blue Jays.

Why the Houston Astros will win

• The Astros have won each of their last seven games following a loss.
• The Blue Jays have lost five of their last six road games against teams that held a losing record.
• The Astros have covered the run line in each of their last seven games following a loss.
• The Blue Jays have failed to cover the run line each of their last four night games against American League opponents that held a losing record.
• The Blue Jays have trailed after 3 innings in eight of their last 10 games at Daikin Park.
• The Blue Jays have lost the first inning in three of their last four games against opponents that held a losing record.
• The Blue Jays have trailed after 5 innings in nine of their last 10 games at Daikin Park against American League opponents that held a losing record.

Why the Toronto Blue Jays will win

• The Blue Jays have won each of their last four games as road underdogs against the Astros following a loss.
• The Astros have lost 10 of their last 12 games as favorites against AL East opponents following a home loss.
• The Blue Jays have covered the run line in each of their last 10 games as road underdogs after playing the previous day.
• The Astros have failed to cover the run line in nine of their last 10 games as home favorites after playing the previous day.
• The Astros have lost the first inning in three of their last four games as home favorites.
• The Astros have trailed after 5 innings in each of their last six Monday games.
• The Blue Jays have led after 3 innings in seven of their last eight road games against AL West opponents that held a losing record.

Houston Astros Player Prop Facts

• Yordan Alvarez has hit at least one home run in four of the Astros’ last five games against the Blue Jays.
• Jeremy Pena has recorded at least one RBI in each of the Astros’ last four games as favorites against the Blue Jays.
• Yainer Diaz has scored at least one run in each of the Astros’ last seven night games against AL East opponents that held a winning record.
• Yainer Diaz has recorded at least one Single in seven of his last eight appearances in night games against AL teams that held a winning record.
• Yainer Diaz has recorded at least one hit in each of the Astros’ last 12 games against AL East opponents that held a winning record.
• Jake Meyers ranks T5th in the league in Steals (7) this season.

Toronto Blue Jays Player Prop Facts

• Anthony Santander has recorded a Double in three of the Blue Jays’ last four games against opponents that held a losing record.
• Anthony Santander has hit at least one home run in three of his last four road appearances against AL West opponents.
• Kevin Gausman has recorded a win in each of his last 10 appearances against AL opponents that held a losing record.
• Anthony Santander has recorded at least one RBI in each of his last four road appearances against AL West opponents.
• Vladimir Guerrero Jr. has scored at least one run in seven of the Blue Jays’ last eight road games against AL West opponents.
• Kevin Gausman has recorded five or more strikeouts in each of his last nine appearances against AL West opponents.
• Ernie Clement has recorded at least one hit in each of the Blue Jays’ last 10 night games against AL opponents that held a losing record.
• Bo Bichette has recorded at least one Single in each of his last eight appearances in night games against AL teams that held a losing record.
• Bo Bichette ranks T3rd in the league in Hits (30) this season.

Astros vs Blue Jays Prediction

We’re getting plus money with the Blue Jays, the team that has had more success swinging the plate this season. The pitching matchup is a bit of a wash as Brown and Gausman have both been solid up to this point. Gausman has allowed 15 hits and seven earned runs in 25.1 innings, while Brown has allowed 15 hits and four earned runs in 24 innings. The difference is that the Blue Jays have been more consistent offensively.

The Astros have yet to find their form offensively, and I don’t believe that starts against a veteran in good form in Gausman. I’ll take a shot at the more favorable price on Monday night.