Cubs vs Mariners Prediction 6/22/25 MLB Picks Today

In this article we will formulate a Cubs vs Mariners prediction for this MLB game on Sunday, June 22nd at Wrigley Field in Chicago, Illinois. Let’s take a look at the prediction for this MLB matchup. 

Chicago Cubs Betting Preview

The Chicago Cubs are 46-30 this season after they split the first two games in this series by scores of 4-9 and 10-7. In their game two win, Chicago jumped out to a 9-1 lead in the third inning, but they did have some pitching issues, before hanging on for the win. The Cubs recorded nine hits and they committed one error in the game, while they were led by Happ, who went 2-4 with two home runs and four RBIs in the win. Chicago started Horton, who allowed seven hits and three earned runs over 4.2 innings, while Keller picked up the win in relief. 

Prior to this series, the Cubs split two games with the Brewers and won three out of four against the Pirates before that. Chicago has won four of their last six games and they are currently first in the NL Central standings. The Chicago pitching staff has a 3.70 ERA with a 1.24 WHIP and a .247 opponent batting average, while their offense has scored 411 runs with a .254 batting average and a .325 on base percentage this season. Pete Crow-Armstrong has led Chicago with 21 home runs and 61 RBIs, while Seiya Suzuki has added 18 home runs and 61 RBIs this year. The projected starting pitcher for Chicago is Colin Rea, who is 4-2 with a 3.84 ERA and a 1.32 WHIP over 68.0 innings pitched this season. 

Seattle Mariners Betting Preview

The Seattle Mariners are 38-37 this year after they lost game two by a score of 10-7 on Saturday afternoon. Seattle trailed 9-1 in the third inning, but they did score the next five runs and did a good job of making the game competitive. The Mariners recorded 14 hits in the game and they were led by Raley and Solano, who both had two RBIs in the loss. Seattle started Hancock, who allowed six hits and nine earned runs over 4.0 innings for the loss, while Pop allowed one earned run in relief. 

Prior to this series, the Mariners lost two out of three against the Red Sox, but did sweep the Guardians in three games before that. Seattle has alternated wins and losses over their last six games and they are currently second in the AL West standings. The Seattle pitching staff has a 3.96 ERA with a 1.29 WHIP and a .250 opponent batting average, while the offense has scored 333 runs with a .245 batting average and a .324 on base percentage this season. Cal Raleigh has led Seattle with 30 home runs and 64 RBIs, while Jorge Polanco has added 11 home runs and 36 RBIs this year. The projected starting pitcher for Seattle is Logan Gilbert, who is 1-2 with a 2.55 ERA and a 0.79 WHIP over 35.1 innings pitched this year. 

Why the Mariners will beat the Cubs

• The Mariners have won each of their last four games against NL Central opponents following a loss.
• The Cubs have lost each of their last six games as underdogs following a win.
• The Cubs have failed to cover the run line in each of their last six games as underdogs following a win.
• The Mariners have covered the run line in each of their last four games against NL Central opponents following a loss.
• The Mariners have won the first inning in each of their last three games as favorites against NL Central opponents.
• The Mariners have led after 3 innings in each of their last eight Sunday games as road favorites.
• The Cubs have trailed after 5 innings in each of their last five games as underdogs.

Total Runs Facts

• Each of the Cubs’ last nine games against AL West opponents have gone OVER the total runs line.
• Each of the Mariners’ last six day games against NL Central opponents have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Mariners’ last 13 day games against National League opponents.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Cubs’ last eight day games against American League opponents.

Chicago Cubs Player Prop Facts

• Ian Happ has hit at least one home run in each of the Cubs’ last three games against opponents that held a winning record.
• Justin Turner has recorded at least one hit in each of his last eight appearances with his team as an underdog against AL opponents.
• Ian Happ has scored at least one run in each of the Cubs’ last eight games against AL West opponents.
• Ian Happ has recorded at least one RBI in each of the Cubs’ last five day games.

Seattle Mariners Player Prop Facts

• Cal Raleigh has hit at least one home run in each of the Mariners’ last four games against NL Central opponents.
• Logan Gilbert has recorded seven or more strikeouts in each of his last seven appearances in day games.
• Victor Robles has scored at least one run in each of his last six appearances with the Mariners as road favorites.
• Cal Raleigh has recorded at least one RBI in each of the Mariners’ last seven games against NL opponents that held a winning record.
• Logan Gilbert has recorded a win in three of his last four appearances in day games.
• Randy Arozarena has recorded at least one Double in each of the Mariners’ last four road games against NL Central opponents.
• Victor Robles has recorded at least one hit in each of his last 10 appearances in day games.

Cubs vs Mariners Prediction 

Chicago was able to tie the series at one with a high scoring win on Saturday afternoon, but they have allowed at least seven runs in three straight games. The Cubs are 25-14 at home this year, while the Mariners are 18-18 on the road. Seattle is second in the AL West, but they are just one game above .500 on the season. The Mariners are starting Gilbert, who has allowed two earned runs or fewer in five straight starts. The Cubs are going with Rea, who has allowed 2, 4, 0, 6, and 6 earned runs in his last five outings. I think Gilbert is the more reliable option, so I will back the Mariners here.