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Pittsburgh Pirates vs Chicago White Sox Prediction 7-18-25 Picks

Chicago White Sox (32-65) vs. Pittsburgh Pirates (39-58)
July 18, 2025 10:40 pm EDT
The Line: Pittsburgh Pirates -163 / Chicago White Sox +133; Over/Under: 8.5
(Get latest betting odds)

The Chicago White Sox and the Pittsburgh Pirates meet Friday in MLB action from PNC Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Chicago White Sox vs. Pittsburgh Pirates prediction.

Starting Pitching Matchup

The Chicago White Sox will send out Jonathan Cannon for the start here, and Cannon is 3-7 with a 4.44 ERA and 61 strikeouts this season. The Pittsburgh Pirates will start Bailey Falter here, and Falter is 6-4 with a 3.79 ERA and 59 strikeouts.

Chicago White Sox Recap

The Chicago White Sox come into this game looking to start the second half right after a 6-5 loss in their last game at the hands of the Cleveland Guardians to sit at 32-65 on the year. After this series, the White Sox will head on the road for a game against the Rays.

White Sox Drop 6 Of Their Last 8 Games

Lenyn Sosa has 77 hits, including 14 doubles and 31 RBIs. Andrew Benintendi has 56 hits, including 10 doubles, 11 home runs, 35 RBIs, and a .233 batting average, while Miguel Vargas has 74 hits, 22 doubles, 10 home runs, and 35 RBIs. Brooks Baldwin has also added 20 RBIs, while Luis Robert Jr. has a team-high 22 stolen bases along with 35 RBIs so far this season. Chase Meidroth has added 63 hits with 11 stolen bases as well as 7 doubles this season.

Why the Chicago White Sox will win

  • The Pirates have lost each of their last four games as home favorites against American League opponents following a win.
  • The White Sox have won 13 of their last 19 games as underdogs following a home loss.
  • The Pirates have failed to cover the run line in each of their last nine games as home favorites against American League opponents following a road win.
  • The White Sox have covered the run line in seven of their last eight road games after going to extra innings.

Chicago White Sox Player Prop Facts

  • Andrew Benintendi has hit at least one home run in three of his last four appearances against NL Central opponents that held a losing record.
  • Miguel Vargas has recorded a Double in each of his three previous appearances against the Pirates after not playing the previous day.
  • Mike Tauchman has recorded at least one hit in each of his last 10 road appearances against opponents that held a losing record.
  • Luis Robert ranks T10th in the league in Steals (22) this season.

Pittsburgh Pirates Recap

The Pittsburgh Pirates come into this game looking to get the ball rolling after ending the first half with a 2-1 win over the Minnesota Twins last time out, to sit at 39-58 on the year. After this series, the Pirates will square off against the Detroit Tigers at home.

Pirates Snap Eight-Game Losing Streak Going Into All-Star Break

Bryan Reynolds has 80 hits with 17 doubles, 10 home runs, and 46 RBIs while also posting 106 strikeouts so far this season. Oneil Cruz has posted a team-high 16 home runs and 37 RBIs with 29 stolen bases, while Isiah Kiner-Falefa has 76 hits with 11 doubles and 12 stolen bases. Cruz also has a team-high 116 strikeouts this season. Tommy Pham has 8 doubles and Andrew McCutchen has 77 hits with 14 doubles, and KeBryan Hayes has 78 hits with 31 RBIs and 10 stolen bases.

Why the Pittsburgh Pirates will win

  • The White Sox have lost each of their last 11 night games against NL Central opponents following a loss.
  • The home team has won 16 of the Pirates’ last 17 games.
  • The White Sox have failed to cover the run line in each of their last seven night games against National League opponents following a home loss.
  • The Pirates have covered the run line in eight of their last nine night games against AL Central opponents that held a losing record.

Pittsburgh Pirates Player Prop Facts

  • Tommy Pham has hit a home run in four of his last nine appearances in night games against AL teams that held a losing record.
  • Andrew McCutchen has recorded a Double in each of his last four appearances against the White Sox.
  • Bryan Reynolds has recorded at least one hit in each of the Pirates’ last 13 home games against AL Central opponents.
  • Oneil Cruz ranks T2nd in the league in Steals (29) this season.

Total Runs Facts

  • Ten of the Pirates’ last 12 games have gone UNDER the total runs line.
  • Eight of the White Sox’s last 10 road games have gone UNDER the total runs line.

Chicago White Sox vs. Pittsburgh Pirates Prediction

I’m on the under in this one. I just think this matchup features two teams that I don’t really trust from an offensive perspective. Cannon hasn’t been a top-tier option for the White Sox this season, but the Pirates haven’t been a team that’s been worth backing for much of anything in the month of July against righties. On the other side, Bailey Falter’s been a solid option for the Pirates for much of the season, and the White Sox were relatively ineffective themselves going into the all-star break, and I just think this game ends up being lower-scoring just because of a lack of offense and nothing else. Give me the under.

Chris Ruffolo's Free Pick: Under 8.5

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Chris Ruffolo

Chris joined the Sports Chat Place team in August 2016 and has a proven system that combines multiple analytical and situational statistics and trends to give out thousands of winning picks over the last three years with winning records across all of the top leagues, Follow Chris Ruffolo on Twitter @ruffthepickdawg

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