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Broncos vs Cardinals Prediction 8/16/25 NFL Picks Today

Arizona Cardinals (1-0) vs. Denver Broncos (1-0)
August 16, 2025 9:30 pm EDT
The Line: Denver Broncos -3; Over/Under: 38.5
(Get latest betting odds)

In this article we will formulate a Broncos vs Cardinals prediction for this NFL game on Saturday, August 16th at Mile High Stadium in Denver, Colorado. Let’s take a look at the prediction for this week two matchup in the preseason. 

Denver Broncos Betting Preview

The Denver Broncos are 1-0 this preseason after they defeated San Francisco by a score of 30-9 last week. Denver trailed 9-0 after the first quarter, but they erupted in the second quarter and led 20-9 at halftime. The Broncos put up three points in the third quarter and seven in the fourth, as they cruised to the win. Denver out gained San Francisco by a total of 368-203, went 6-16 on third down, and won the turnover battle 4-0 in the game. Jarrett Stidham went 14-15 for 136 yards and two touchdowns, Bo Nix went 6-11 for 31 yards, and Sam Ehlinger went 6-10 for 55 yards and one score. Tyler Badie rushed for 32 yards, while Trent Sherfield Sr. caught three passes for 73 yards and one touchdown. The Denver defense was led by Jackson, who had six tackles, while Franklin-Myers and Bonitto each had a sack. 

Denver went 3-0 in the preseason in 2024 with wins over Indianapolis, Green Bay, and Arizona by scores of 34-30, 27-2, and 38-12. The Broncos will most likely sit most of their starters for this contest, which means Ehlinger and Stidham will see all of the action under center. 

Arizona Cardinals Betting Preview

The Arizona Cardinals are 1-0 this preseason after they defeated Kansas City by a score of 20-17 last week. Arizona trailed 7-0 after the first quarter and they trailed 14-3 in the second, but they scored 14 late points to lead 17-14 at the half. The Cardinals failed to score in the third quarter, but they scored the only points in the fourth to escape with the win. Arizona out gained KC by a total of 355-249, went 4-9 on third down conversions, and lost the turnover battle 3-2 in the win. Kyler Murray went 7-8 for 96 yards and one interception, Jacoby Brissett went 5-8 for 81 yards and two touchdowns, and Clayton Tune went 5-9 for 47 yards and an interception in the game. Bam Knight rushed for 51 yards, while Emari Demercado caught two passes for 56 yards and one touchdown. The Arizona defense was led by Robinson, who had six tackles in the game, while Collier had the lone sack for the Cardinals. 

Arizona went 0-3 in the 2024 preseason with losses against New Orleans, Indianapolis, and Denver by scores of 16-14, 21-13, and 38-12. The Cardinals are also not expected to play their starters, so we will see Tune and Brissett at quarterback. 

David Racey is 7-3 (70%) in the NFL Preseason so far this year. Click here for his premium plays for this week!

Broncos vs Cardinals Prediction 

Both of these teams were able to get a win in their first preseason game last week and they will look to make it two in a row here. Denver has some nice depth at quarterback with Stidham and Ehlinger, but Arizona has plenty of experience with Brissett. I think we are going to see both offenses play well in this game, as the backup quarterbacks are fighting for depth chart positioning, so give me the over in this one. 

David Racey's Free Pick: Over 38.5

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David Racey

David started writing about sports in 2015, but sports has been his passion for as long as he can remember. David spends most of his free time watching pretty much anything sports related from Baseball to Tennis and everything in between. David likes to analyze statistics and recent results to form an unbiased opinion on whatever game he is breaking down. Follow David on Twitter at @itsyerboi41

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