
Giants vs Cubs Prediction 8/26/25 MLB Picks Today
Chicago Cubs (76-55) vs. San Francisco Giants (63-68)
August 26, 2025 9:45 pm EDT
The Line: San Francisco Giants 118 / Chicago Cubs -143; Over/Under: 7.5
(Get latest betting odds)
The Chicago Cubs and San Francisco Giants meet Tuesday in MLB action at Oracle Park. Here’s a Giants vs Cubs Prediction. This article will include a Giants vs Cubs Pick.
Chicago Cubs Betting Preview
The Chicago Cubs are 76-55 on the year and play the Rockies, Braves, and Nationals next. The Chicago Cubs are batting .249 on the season, have a .319 OBP, and a .428 slugging percentage. The Chicago Cubs pitching staff has a 3.76 ERA and a 1.19 WHIP. Nico Hoerner leads the Chicago Cubs with 138 hits and 50 RBI, while Pete Crow-Armstrong and Kyle Tucker have combined for 246 hits and 151 RBI.
Matthew Boyd gets the ball for the Chicago Cubs, and he is 12-6 with a 2.61 ERA and 129 strikeouts this season. This will be Boyd’s second career game against the San Francisco Giants.
San Francisco Giants Betting Preview
The San Francisco Giants are 63-68 on the year and play the Orioles, Rockies, and Cardinals next. The San Francisco Giants are batting .231 on the season, have a .308 OBP, and a .376 slugging percentage. The San Francisco Giants pitching staff has a 3.74 ERA and a 1.29 WHIP. Heliot Ramos leads the San Francisco Giants with 130 hits and 55 RBI while Jung Hoo Lee and Willy Adames have combined for 230 hits and 112 RBI.
Justin Verlander gets the ball for the San Francisco Giants, and he is 1-10 with a 4.64 ERA and 99 strikeouts this season. Verlander is 2-0 with a 2.35 ERA and 22 strikeouts in his career against the Chicago Cubs.
Why the San Francisco Giants will win
- The Cubs have lost seven of their last eight games as favorites against National League opponents following a win.
- The Giants have won four of their last five games as underdogs against NL Central opponents.
- The Cubs have failed to cover the run line in each of their last eight games as favorites against National League opponents following a win.
- The Giants have covered the run line in each of their last five games as underdogs against NL Central opponents.
- The Giants have led after 5 innings in eight of their last 10 night games against the Cubs at Oracle Park.
- The Giants have led after 3 innings in four of their last five night games against the Cubs at Oracle Park.
Why the Chicago Cubs will win
- The Giants have lost each of their last eight night games against NL Central opponents following a win.
- The Cubs have won seven of their last eight night games against National League opponents that held a losing record.
- The Giants have failed to cover the run line each of their last seven home games against teams that held a winning record.
- The road team has covered the run line in four of the last five games between the Cubs and Giants.
- The Cubs have led after 3 innings in each of their last five night games.
- The Cubs have led after 5 innings in each of their last five night games.
San Francisco Giants Player Prop Facts
- Willy Adames has hit a home run in each of his last two appearances with his team as a home underdog against the Cubs.
- Casey Schmitt has recorded at least one Double in three of his last four home appearances against NL Central opponents that held a winning record.
- Justin Verlander has recorded five or more strikeouts in each of his last six appearances with his team as a home underdog.
- Dominic Smith has recorded at least one hit in each of his last 14 appearances in night games.
Chicago Cubs Player Prop Facts
- Kyle Tucker has hit at least one home run in each of the Cubs’ last two night games against opponents that held a losing record.
- Dansby Swanson has recorded a Double in three of the Cubs’ last four games against opponents that held a losing record.
- Matthew Boyd has recorded a win in four of his last five appearances with the Cubs as favorites against NL West opponents.
- Matthew Boyd has recorded five or more strikeouts in eight of his last nine appearances in night games against teams that held a losing record.
- Seiya Suzuki has recorded at least one hit in each of his last 16 appearances in night games against NL West teams that held a losing record.
- Matthew Boyd ranks 5th amongst qualified players for Earned Run Average (2.61) this season.
Giants vs Cubs Prediction
The Cubs are not only the more trustworthy team, but they have a clear edge on the mound. Boyd has been great with a 2.61 ERA and 1.04 WHIP, and he’s allowed just nine runs in his last 24.1 innings. Verlander has allowed 23 hits and 12 earned runs in his last 21.1 innings, and the Giants have lost each of his last five starts. At 42 years old, Verlander is a shell of himself these days. Give me the Cubs and the reasonable price.