Giants vs Orioles Prediction 8/29/25 MLB Picks Today

The Baltimore Orioles and the San Francisco Giants meet Friday in MLB action from Oracle Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Giants vs Orioles Prediction.

Starting Pitching Matchup

The Baltimore Orioles will send out Dean Kremer for the start here and Kremer is 9-9 with a 4.19 ERA and 127 strikeouts this season. In his career, Kremer is 1-1 with a 4.50 ERA and 13 strikeouts against San Francisco. The San Francisco Giants will trot out Robbie Ray here and Ray is 10-6 with a 2.93 ERA and 158 strikeouts this season. In his last five starts against Baltimore, Ray is 1-2 with a 3.58 ERA and 37 strikeouts.

Baltimore Orioles Recap

The Baltimore Orioles come into this game looking to rebound from a 3-2 loss at the hands of the Boston Red Sox in Thursday’s series finale to sit at 60-74 this season. After this series, the Orioles will head on the road for a series against the San Diego Padres.

Orioles Lose Four In A Row & 7 Of Last 8

Adley Rutschman has 70 hits with 16 doubles, 9 homers and 29 RBIs. Jackson Holliday has 120 hits with 18 doubles, 2 triples, 15 homers and 49 RBIs. Gunnar Henderson has 132 hits with 30 doubles, 5 triples, 16 home runs and 59 RBIs with 20 stolen bases and 119 strikeouts while Holliday has a team-high 120 strikeouts as well this season. 

Why the Baltimore Orioles will win

• The Giants have lost each of their last seven Friday games as favorites against AL East opponents.
• The Orioles have won each of their last four games as road underdogs against the Giants following a loss.
• The Giants have failed to cover the run line in 19 of their last 20 home games against AL East opponents following a win.
• The Orioles have covered the run line in each of their last six road games.

Baltimore Orioles Player Prop Facts

• Dean Kremer has recorded five or more strikeouts in seven of his last eight appearances.
• Dylan Carlson has recorded a Double in each of his last four appearances with the Orioles as underdogs.
• Tyler O’Neill has hit at least one home run in four of his last five appearances against NL West opponents that held a losing record.
• Adley Rutschman has recorded at least one hit in each of his last eight road appearances against NL opponents.

San Francisco Giants Recap

The San Francisco Giants come into this game looking to add on to their win over the Chicago Cubs last time out to sit at 66-68 this season. After this series, the Giants will head on the road for a game against the Colorado Rockies.

Giants Pick Up 5th Win In A Row

Jung Hoo Lee has 125 hits including a team-high 30 doubles along with 10 triples, 7 home runs and 48 RBIs with 10 stolen bases while Heliot Ramos has 135 hits with 23 doubles, 16 home runs and 57 RBIs. Wilmer Flores also 14 home runs and 64 RBIs while Tyler Fitzgerald has 9 stolen bases as well on the year. Matt Chapman also has 84 hits with 18 home runs and 48 RBIs along with 16 doubles and Willy Adames has 110 hits with 18 doubles, 24 home runs and 69 RBIs of his own this season. 

Why the San Francisco Giants will win

• The Orioles have lost seven of their last eight games.
• The Giants have won each of their last five games.
• The Orioles have failed to cover the run line in five of their last six night games against teams that held a losing record.
• The Giants have covered the run line in five of their last six games.

San Francisco Giants Player Prop Facts

• Willy Adames has hit at least one home run in three of the Giants’ last four games as favorites against AL East opponents.
• Dominic Smith has recorded at least one hit in each of his last 15 appearances in night games.
• Rafael Devers ranks 9th amongst qualified players for On Base Percentage (.378) this season.

Total Runs Facts

• Eight of the Giants’ last nine games as favorites against AL East opponents have gone OVER the total runs line.
• Each of the Orioles’ last five games have gone UNDER the total runs line.

Giants vs Orioles Prediction

I’m on the Giants in this one. I get the case to be made for either side in this one, but I’m backing the Giants in their current form, as you just have two teams headed in completely different directions at this point in the year. The Orioles are slumping, and I just think that Robbie Ray is a tough pitcher to take down, especially at home. Give me the Giants in this one.