Jets vs Bills Prediction 9/14/25 NFL Picks Today

The Buffalo Bills and the New York Jets meet Sunday in NFL action from MetLife Stadium. Here’s a Jets vs Bills prediction. We will look at this from a betting perspective and determine the best Jets vs Bills pick.

Buffalo Bills Betting Preview

The Bills were all over the place during the preseason, going 1-2 overall through those three exhibition games. Buffalo opened up versus the New York Giants, logging a 34-25 loss. Game two against the Chicago Bears was even worse as the Bills stumbled to a shutout loss 38-0. In their final preseason outing versus the Tampa Bay Buccaneers on August 23, Buffalo jumped out to a 17-10 halftime lead and managed to hold on for the win 23-19. QB Shane Buechele finished with 278 yards and a touchdown on 25-of-30 passing. Frank Gore Jr. scored a rush TD, but Elijah Young led the ground game on 16 carries for 53 yards. Kristian Wilkerson led the receivers on five catches for 46 yards.

In their season opener Sunday night versus the Baltimore Ravens, the Bills were in trouble by the fourth quarter, trailing 34-19. Buffalo then proceeded to outscore Baltimore 22-6 the rest of the way, pulling off a wild comeback win 41-40. Josh Allen threw for 394 yards and a pair of scores, while also rushing for two more TDs. James Cook had 44 yards with a rush score on 13 totes, and Keon Coleman caught eight balls for 112 yards and a touchdown.

New York Jets Betting Preview

Over on the Jets’ side, they started out their preseason pretty well but ultimately went just 1-2 in exhibition games. New York had a good game against the Green Bay Packers in the opener, eventually powering out the win 30-10. In their game two matchup versus the rival New York Giants however, the Jets faltered 31-12 for a loss. The preseason finale versus the champion Philadelphia Eagles was much closer but still another defeat, this time 19-17. New York got 99 yards and an interception from Brady Cook on 13-of-19 passing. Tops in rushing was Lawrance Toafili with seven totes for 38 yards and a score. Jamaal Pritchett was the leading receiver on the team with four grabs for 54 yards total.

The Jets’ regular season kicked off with a matchup versus the Pittsburgh Steelers at MetLife Stadium on Sunday. New York was looking pretty good after the third quarter, holding a 26-17 lead. After a 17-6 deficit from there however, the Jets ended up falling 34-32. Justin Fields went 16-of-22 for 218 yards and a touchdown while rushing 12 times for 48 yards and two more scores. Tops in the running game was Breece Hall with 19 carries for 107 yards, and Garrett Wilson led the receivers with his seven catches for 95 yards and a touchdown.

Buffalo Bills @ New York Jets Betting Trends: Week 2

Why the New York Jets will win

• The home team has won each of the Bills’ last seven games.
• The Bills have lost each of their last two games as road favorites.
• The home team has covered the spread in each of the Bills’ last six games.
• The Bills have failed to cover the spread in each of their last three road games following a win.
• The Bills have lost the first quarter in six of their last seven road games against teams that held a losing record.
• The home team has won the first half in each of the Jets’ last seven games.

Why the Buffalo Bills will win

• The Bills have won each of their last six Week 2 games.
• The Jets have lost each of their last seven games as underdogs.
• The Jets have failed to cover the spread in each of their last seven Sunday games against teams that held a winning record.
• The Bills have covered the spread in each of their last four Week 2 games.
• The Jets have lost the first quarter in each of their last nine Week 2 games.
• The Bills have won the first half in each of their last eight games against the Jets.
• The Bills have scored the first touchdown in each of their last eight games against the Jets.

Total Points Facts

• Each of the Bills’ last seven road games in September have gone UNDER the total points line.
• Each of the Jets’ last seven September home games against AFC East opponents have gone UNDER the total points line.
• Eight of the last nine games between AFC East teams have gone OVER the total points line.

New York Jets Player Prop Facts

• Justin Fields has scored at least one touchdown in five of his last six home appearances against conference opponents.
• Breece Hall has recorded 72+ rushing and receiving yards in seven of the Jets’ last eight home games against AFC opponents.
• Allen Lazard has recorded 13+ receiving yards in each of his last 10 home appearances against division opponents.
• Justin Fields has recorded 218+ passing yards in each of his last three September appearances.
• Breece Hall has recorded 52+ rushing yards in each of the Jets’ last seven home games.
• Heading into Week 2, Justin Fields ranks T1st in the NFL in touchdowns (2) this season.

Buffalo Bills Player Prop Facts

• James Cook has scored at least one touchdown in each of the Bills’ last six regular season games against AFC opponents.
• Josh Allen has recorded 35+ rushing yards in each of the Bills’ last five September games as road favorites.
• Curtis Samuel has recorded 28+ rushing and receiving yards in each of his five previous appearances with his team as a road favorite against AFC opponents.
• Josh Palmer has recorded 38+ receiving yards in each of his last six road appearances against AFC opponents.
• Josh Allen has recorded 236+ passing yards in nine of the Bills’ last 10 September games as favorites against AFC opponents.
• Josh Allen has recorded 23+ completions in nine of the Bills’ last 10 September games as favorites against AFC opponents.
• Heading into Week 2, Josh Allen ranks 1st in the NFL in passing yards (394) this season.

Matchup/League Facts

• Jets – one different players have recorded multi-touchdown games this season – equal-most in the NFL, heading into Week 2.
• Jets – one different players have recorded 80+ rushing yards in a game this season – equal-most in the NFL, heading into Week 2.
• Bills – one different players have recorded multi-touchdown games this season – equal-most in the NFL, heading into Week 2.
• Bills – four different players have recorded at least one touchdown this season – equal-most in the NFL, heading into Week 2.

Jets vs Bills Prediction

I’ll stay with the Bills. On Sunday Buffalo needed a wild fourth quarter to pull off a big win over a very good Baltimore team. The first three quarters raised a few concerns, but you can’t argue with the finish. The Bills did end up surrendering 238 rushing yards and 8.6 yards per play, but the offense helped keep pace on 497 total yards (389 passing) and 29 first downs.

As for the Jets, they put up a fairly valiant effort versus a plucky Pittsburgh team in their first outing of the year but ultimately fell short. New York generated 394 yards on offense (212 passing) with 23 first downs while going 7-of-14 on third-down tries. The defense was great against the rush (53 yards) and held the Steelers to just 4-of-10 on third downs. New York is going to need to log a robust effort on both sides of the ball in order to keep pace with Buffalo this weekend though, and I don’t think they’ve got it in them to do so.