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Falcons vs Panthers Prediction 9/21/25 NFL Picks Today

Falcons vs Panthers
September 21, 2025 1:00 pm EDT
The Line: Falcons -5.5 / Over/Under 43.5
(Get latest betting odds)

In this article, we will formulate a Falcons vs Panthers Prediction for this NFL Week 3 game on Sunday, September 21st at the Bank of America Stadium. Let’s take a look at the prediction for this NFL matchup.

Carolina Panthers Preview

Carolina has a 0-2 record this season. Offensively, they average 16.0 points per game, which ranks 29th in the NFL. Defensively, they allow 26.5 points per game, which ranks 23rd. Carolina averages 303.5 total yards per game, with 81 rushing yards and 222.5 passing yards per game. They allow 335.5 total yards per game, 151 rushing and 184.5 passing yards per game.


Bryce Young leads the Panthers with 53/90 completed passes and 445 total passing yards. He also adds 42 rushing yards. Chuba Hubbard leads the team in rushing yards, with 95, while Bryce Young adds 42 rushing yards. Tetairoa McMillan has a team-high 11 caught passes for a team-high 168 receiving yards. Chuba Hubbard has caught 8 passes for 71 yards, and two touchdowns.

Defensively, Tre’von Moehrig has a team-high 20 total tackles, 14 of them solo. D.J. Wonnum and Princely Umanmielen lead the Panthers in sacks, with one apiece. Jaycee Horn and D.J. Wonnum each had one interception.

Atlanta Falcons Preview

Atlanta has a 1-1 record this season. Offensively, they average 21.0 points per game, which ranks 21st in the NFL. Defensively, they allow 14.5 points per game, which ranks 2nd. Atlanta averages 342 total yards per game, with 143.5 rushing yards and 198.5 passing yards per game. They allow 229 total yards per game, 89.5 rushing and 139.5 passing yards per game.

Michael Penix leads the Falcons with 40/63 completed passes and 397 total passing yards. He also adds 20 rushing yards. Bijan Robinson leads the team in rushing yards, with 167, while Tyler Allgeier adds 100 rushing yards. Bijan Robinson has a team-high 9 caught passes for a team-high 125 receiving yards, and has one touchdown. Drake London has caught 11 passes for 104 yards.

Defensively, Billy Bowman has a team-high 10 total tackles, 4 of them solo. Zach Harrison leads the Falcons in sacks, with 1.5. Xavier Watts and Billy Bowman each have one interception.

Atlanta Falcons @ Carolina Panthers Betting Trends: Week 3

 

Why the Carolina Panthers will win

  • The underdogs have won five of the Falcons’ last six games at Bank of America Stadium.
  • The Falcons have lost four of their last five games as road favorites following a road win.
  • The Panthers have covered the spread in each of their last six games as underdogs following a loss.
  • The Falcons have failed to cover the spread in each of their last six games as road favorites following a road win.
  • The Panthers have won the first half in each of their last seven Week 3 games.
  • The Falcons have lost the first quarter in each of their last three games as road favorites following a road win.
  • The Panthers have scored the first touchdown in each of their last four Week 3 games.

Why the Atlanta Falcons will win

  • The Panthers have lost eight of their last nine games in September.
  • The Falcons have won each of their last four September games against the Panthers.
  • The Panthers have failed to cover the spread in each of their last five home openers as underdogs.
  • The Falcons have covered the spread in five of their last six road games in September.
  • The Panthers have lost the first quarter in three of their last four games against NFC South opponents.
  • The Falcons have scored the first touchdown in four of their last five Week 3 games.
  • The Panthers have lost the first half in each of their last 14 games following a road loss.

Total Points Facts

  • Each of the Panthers’ last seven games at Bank of America Stadium have gone OVER the total points line.
  • Each of the Falcons’ last four games as favorites following a win have gone UNDER the total points line.
  • Eleven of the last 13 games between NFC South teams have gone OVER the total points line.

Carolina Panthers Player Prop Facts

  • Chuba Hubbard has scored at least one touchdown in seven of his last eight appearances with the Panthers as underdogs.
  • Chuba Hubbard has recorded 64+ rushing yards in six of the Panthers’ last seven games at Bank of America Stadium as moderate underdogs (+3.5 to +7.0 points).
  • Chuba Hubbard has scored the last touchdown in five of his last six appearances with the Panthers as underdogs on the East Coast.
  • Andy Dalton has recorded 250+ passing yards in each of his last four Week 3 appearances.
  • David Moore has recorded 17+ receiving yards in each of the Panthers’ last six games at Bank of America Stadium.
  • Rico Dowdle has recorded 51+ rushing and receiving yards in each of his last eight Sunday regular season home appearances.
  • Andy Dalton has recorded 25+ completions in each of his three previous Sunday appearances at Bank of America Stadium.
  • Heading into Week 3, Bryce Young has recorded the most pass attempts in a single game this season (55 vs Cardinals, Week 2).

Atlanta Falcons Player Prop Facts

  • Bijan Robinson has scored two touchdowns in four of the Falcons’ last five day games against teams with a losing record.
  • Bijan Robinson has recorded 86+ rushing yards in each of the Falcons’ last six games as favorites.
  • Bijan Robinson has recorded 27+ receiving yards in each of the Falcons’ last four September games as favorites.
  • Bijan Robinson has scored at least one touchdown in eight of the Falcons’ last nine games played on the East Coast.
  • Ray-Ray McCloud has recorded 33+ rushing and receiving yards in six of the Falcons’ last seven games against NFC South opponents.
  • Kirk Cousins has recorded 276+ passing yards in each of his last three road appearances against NFC opponents.
  • Kirk Cousins has recorded 23+ completions in four of his last five appearances against NFC opponents.
  • Heading into Week 3, Parker Romo has recorded the equal-most made field goals in a single game this season (5 vs Vikings, Week 2).

Matchup/League Facts

  • Heading into Week 3, the Panthers rank 32nd in the NFL in sacks (1.0) this season.
  • Heading into Week 3, the Panthers rank T1st in the NFL in 4th down attempts (6) this season.
  • Falcons – two different players have recorded 50+ rushing yards in a game this season – equal-most in the NFL, heading into Week 3.
  • Falcons – two different players have recorded 60+ rushing yards in a game this season – equal-most in the NFL, heading into Week 3.

Falcons vs Panthers Prediction

Both teams were tied 1-1 wins last season, with each one winning on the road. the Panthers won in Atlanta by 44-38 in overtime, while the Falcons won in Carolina by 38-20. Both teams are tied 5-5 wins in their last 10 head-to-head meetings, but the Panthers are 3-2 in their last 5 home meetings against the Falcons.

In this Falcons vs Panthers Prediction, the Falcons are coming as -5.5-point road favorites, with the total set at 43.5 points. Carolina is still winless, but are playing their first home game of the season, so they will be pumped in front of their home crowd. On the flip side, Atlanta’s only win has been on the road against the Vikings last week, but I don’t trust them as road favorites in a second straight road game, so I see no value on either side. Both teams are a combined 3-1 to the under this season, as they have 42.5 and 35.5 average total points this season. The total is set at 43.5 points, so I will go under than number in this one.

Nikos Lagouretos's Free Pick: Under 43.5

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