Phillies vs Diamondbacks Prediction 9/20/25 MLB Picks Today

In this article, we will formulate a Phillies vs Diamondbacks Prediction for this MLB game on Saturday, September 20^th at the Chase Field in the second game of this series, with the Phillies having the 1-0 lead. Let’s take a look at the prediction for this MLB matchup.

Arizona Diamondbacks Preview

The Arizona Diamondbacks have a 77-77 record this season and are sitting on the third place of the NL West. The Diamondbacks have a 40-36 home record and are 74-71 in over/under They are coming off a 2-8 home defeat by the Phillies, and have back-to-back losses. They are playing the Padres and the Dodgers next.

The Diamondbacks have a .250 batting average this season, .324 OBP and .434 slugging percentage. Arizona’s pitching staff has a 4.46 ERA and 1.31 WHIP. Geraldo Perdomo leads the Diamondbacks with 163 hits, adding a team-high 97 RBI. He Is also the team’s best hitter with a .289 batting average, while Corbin Carroll leads the team in home runs with 30.

Zac Gallen (R) is the projected starting pitcher for the Diamondbacks, and he has a 12-14 record, 4.73 ERA and 1.25 WHIP.

Philadelphia Phillies Preview

The Philadelphia Phillies have a 92-62 record this season and are sitting on the first place of the NL East. They have a 41-38 road record, and are 69-75 in over/under. They are coming off an 8-2 road victory over the Dbacks, and have four consecutive wins. They are playing the Twins and the Marlins next.

The Phillies have a .260 batting average this season, .330 OBP and .432 Slugging percentage. Philly’s pitching staff has a 3.84 ERA and 1.24 WHIP. Trea Turner leads the Phillies with 179 hits and he is the team’s best hitter, with a .305 batting average. Kyle Schwarber leads the team with 128 RBI and a team-high 53 home runs.

Aaron Nola (R) is the projected starting pitcher for the Phillies, and he has a 4-9 record, 6.44 ERA and 1.43 WHIP.

Philadelphia Phillies @ Arizona Diamondbacks Betting Trends: September 20, 2025

• Probable Starting Pitcher: Zac Gallen      Record this season: 12-14      ERA: 4.73
• Home Record: 5-7
• Last 5 against Phillies: 1-2

Why the Arizona Diamondbacks will win

• The Diamondbacks have won five of their last six games after playing the previous day.
• The Phillies have lost four of their last five games against NL West opponents following a win.
• The Phillies have failed to cover the run line in four of their last five games against NL West opponents following a win.
• The Diamondbacks have covered the run line in six of their last eight home games against the Phillies following a loss.
• The Diamondbacks have won the first inning in each of their last 10 home games against National League opponents that held a winning record.
• The Phillies have trailed after 3 innings in each of their last four games at Chase Field.
• The Phillies have trailed after 5 innings in nine of their last 10 games as road underdogs against NL West opponents.

• Probable Starting Pitcher: Aaron Nola      Record this season: 4-9      ERA: 6.44
• Road Record: 0-5
• Last 5 against Diamondbacks: 3-2

Why the Philadelphia Phillies will win

• The Diamondbacks have lost each of their last four games as favorites against NL East opponents.
• The Phillies have won six of their last seven games as underdogs.
• The Diamondbacks have failed to cover the run line in eight of their last nine games as favorites against National League opponents.
• The Phillies have covered the run line in eight of their last nine night games against National League opponents.

Total Runs Facts

• Nine of the Phillies’ last 10 games have gone OVER the total runs line.
• Each of the Diamondbacks’ last five games against NL East opponents have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in 14 of the Diamondbacks’ last 15 home games against National League opponents.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Phillies’ last four games at Chase Field.

Arizona Diamondbacks Player Prop Facts

• Alek Thomas has hit a home run in each of his last two home appearances against the Phillies after playing the previous day.
• Zac Gallen has recorded a win in four of his last five appearances with the Diamondbacks as favorites against NL opponents.
• Zac Gallen has recorded six or more strikeouts in each of his last five home appearances against NL opponents.
• Corbin Carroll has recorded at least one hit in each of the Diamondbacks’ last 19 games as favorites.
• Lourdes Gurriel Jr. has recorded a Double in four of his last five appearances in night games against NL East teams that held a winning record.
• Geraldo Perdomo ranks 5th amongst qualified players for On Base Percentage (.391) this season.

Philadelphia Phillies Player Prop Facts

• Max Kepler has hit a home run in five of his last seven appearances against the Diamondbacks after playing the previous day.
• Alec Bohm has recorded a Double in four of the Phillies’ last five road games against the Diamondbacks.
• Aaron Nola has recorded a win in three of his last four appearances against NL opponents.
• Aaron Nola has recorded six or more strikeouts in eight of his last nine road appearances against NL opponents.
• Trea Turner has recorded at least one hit in each of his last 15 road appearances.
• Kyle Schwarber ranks 2nd in the league in Home Runs (53) this season.

Matchup/League Facts

• The Diamondbacks rank 1st in the league for triples this season (37).
• The Diamondbacks rank 3rd in the league for RBIs this season (739).
• The Phillies rank 2nd in the league for walks allowed this season (418).
• The Phillies rank 3rd in the league for hits this season (1363).

Phillies vs Diamondbacks Prediction

The Phillies are 3-1 in their last 4 head-to-head meetings against the Diamondbacks, but the Dbacks are 3-1 in their last 4 meetings in Arizona. Over is 4-2 in their last 6 meetings.

In this Phillies vs Diamondbacks Prediction, the Diamondbacks are coming as -115 home favorites. Gallen has been in good form for the Dbacks lately, having one earned run or less in four of his last five starts, and he has been slightly better at home. On the flip side, Nola has been terrible for the Phillies this season, and has been atrocious on the road, with a 7.00 ERA. He has 6 earned runs in two of his last three starts, and I don’t trust him on the road against a Dbacks team fighting for a Wild Card spot. Take the Arizona Diamondbacks to get the job done at home in this one.