Giants vs Cardinals Prediction 9/23/25 MLB Picks Today

The St. Louis Cardinals and San Francisco Giants meet Tuesday in MLB action at Oracle Park. Here’s a Giants vs Cardinals Prediction. This article will include a Giants vs Cardinals Pick.

St. Louis Cardinals Betting Preview

The St. Louis Cardinals are 77-80 on the year and play the Cubs next. The St. Louis Cardinals are batting .245 on the season, have a .315 OBP, and a .378 slugging percentage. The St. Louis Cardinals pitching staff has a 4.23 ERA and a 1.32 WHIP. Alec Burleson leads the St. Louis Cardinals with 141 hits and 67 RBI, while Brendan Donovan and Willson Contreras have combined for 253 hits and 128 RBI.

Andre Pallante gets the ball for the St. Louis Cardinals, and he is 6-15 with a 5.29 ERA and 107 strikeouts this season. Pallante is 1-0 with a 4.95 ERA and 13 strikeouts in his career against the San Francisco Giants.

San Francisco Giants Betting Preview

The San Francisco Giants are 77-80 on the year and play the Rockies next. The San Francisco Giants are batting .234 on the season, have a .311 OBP, and a .384 slugging percentage. The San Francisco Giants pitching staff has a 3.85 ERA and a 1.30 WHIP. Heliot Ramos leads the San Francisco Giants with 154 hits and 65 RBI while Jung Hoo Lee and Willy Adames have combined for 269 hits and 135 RBI.

Logan Webb gets the ball for the San Francisco Giants, and he is 14-11 with a 3.27 ERA and 211 strikeouts this season. Webb is 3-3 with a 5.30 ERA and 33 strikeouts in his career against the St. Louis Cardinals.

St. Louis Cardinals @ San Francisco Giants Betting Trends: September 23, 2025

• Probable Starting Pitcher: Logan Webb      Record this season: 14-11      ERA: 3.27
• Home Record: 7-4
• Last 5 against Cardinals: 3-2

Why the San Francisco Giants will win

• The Cardinals have lost nine of their last 10 games against NL West opponents following a road win.
• The Giants have won four of their last five home games following a loss.
• The Cardinals have failed to cover the run line in seven of their last eight games against NL West opponents following a win.
• The Giants have covered the run line in each of their last four games against NL Central opponents following a loss.
• The Cardinals have trailed after 5 innings in each of their last eight Tuesday games against NL West opponents that held a losing record.
• The Cardinals have trailed after 3 innings in six of their last seven road games against NL West opponents that held a losing record.
• The Giants have won the first inning in each of their last four night games at Oracle Park.

• Probable Starting Pitcher: Andre Pallante      Record this season: 6-15      ERA: 5.29
• Road Record: 2-8
• Last 5 against Giants: 1-0

Why the St. Louis Cardinals will win

• The Giants have lost each of their last seven games as favorites against National League opponents following a home loss.
• The Cardinals have won five of their last six games as underdogs against the Giants.
• The Giants have failed to cover the run line in each of their last 11 games as favorites against National League opponents following a home loss.
• The Cardinals have covered the run line in each of their last eight games as underdogs against the Giants.
• The Cardinals have led after 5 innings in seven of their last eight games as underdogs.
• The Cardinals have led after 3 innings in six of their last eight games as underdogs.

Total Runs Facts

• Eight of the Giants’ last nine home games after playing the previous day have gone OVER the total runs line.
• Four of the Cardinals’ last five road games against National League opponents have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in eight of the Giants’ last nine night games.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Cardinals’ last three night games at Oracle Park.

San Francisco Giants Player Prop Facts

• Rafael Devers has hit a home run in each of the Giants’ last two night games.
• Logan Webb has recorded six or more strikeouts in each of his last 11 appearances against opponents that held a losing record.
• Jung Hoo Lee has recorded at least one hit in each of his last 10 appearances in night games against teams that held a losing record.
• Logan Webb has recorded a win in four of his last five appearances against opponents that held a losing record.
• Logan Webb ranks 3rd in the league for total Strikeouts (211) this season.

St. Louis Cardinals Player Prop Facts

• Masyn Winn has recorded at least one hit in each of his last 13 road appearances against NL West opponents that held a losing record.
• Willson Contreras has recorded a Double in each of his last three road appearances against NL West opponents that held a losing record.
• Willson Contreras has hit a home run in three of his last four road appearances against opponents that held a losing record.
• Victor Scott II ranks T10th in the league in Steals (33) this season.

Matchup/League Facts

• The Giants rank 1st in the league for home runs allowed this season (137).
• The Giants rank 29th in the league for steals this season (66).
• The Cardinals rank 30th in the league for triples this season (8).
• The Cardinals rank 29th in the league for strikeouts this season (1166).

Giants vs Cardinals Prediction

This is a big series as the Cardinals and Giants are fighting for a wild card spot. I’m siding with the Giants on Tuesday. Pallante has been hittable all season with his 5.29 ERA and 1.44 WHIP, and the Cardinals have lost 8 of his last 9 starts. As I’ve said many times before, Webb is great at Oracle, where he has a 2.85 ERA and 1.13 WHIP through 536 innings. Webb has a 60.3 percent winning percentage at Oracle through 85 starts. We’ve made nice coin over the years backing Webb at home. It should be no different in a big spot to keep playoff hopes alive. Give me the Giants. Of course, I’ll lay the RL to shave down the juice.