Yankees vs White Sox Prediction 9/25/25 MLB Picks Today

In this article we will formulate a Yankees vs White Sox prediction for this MLB game on Thursday, September 25th at Yankee Stadium in New York. Let’s take a look at the prediction for this MLB matchup. 

New York Yankees Betting Preview

The New York Yankees are 90-68 this year after they won the first two games in this series by scores of 3-2 and 8-1. In their game two win, New York trailed 1-0 in the second inning, but immediately answered and ran away with the victory. The Yankees recorded 10 hits and they committed one error in the game, while they were led by Judge, who went 3-4 with two home runs and four RBIs in the win. New York started Fried, who allowed four hits and one earned run over 7.0 innings for the win, while Williams and Blackburn closed out the game. 

Prior to this series, the Yankees won three out of four against the Orioles and two out of three against the Twins. New York has won seven of their last eight games and they are tied for first in the AL East with Toronto. The New York pitching staff has a 3.94 ERA with a 1.26 WHIP and a .231 opponent batting average, while the offense has scored 827 runs with a .251 batting average and a .332 on base percentage this season. Aaron Judge has led New York with 51 home runs and 109 RBIs, while Cody Bellinger has added 29 home runs and 97 RBIs this year. The projected starting pitcher for New York is Carlos Rodon, who is 17-9 with a 3.04 ERA and a 1.06 WHIP over 189.1 innings pitched this year. 

Chicago White Sox Betting Preview

The Chicago White Sox are 58-100 this season after they lost game two by a score of 8-1 on Wednesday night. Chicago led 1-0 early in the game, but failed to score over the last seven innings for the loss. The White Sox recorded five hits in the game and they were led by Sosa, who went 1-3 with one RBI in the loss. Chicago started Ellard, who opened the game, while Cannon allowed five earned runs over 4.1 innings for the loss. 

Prior to this series, the White Sox lost two out of three against the Padres and all three against the Orioles. Chicago has lost ten of their last eleven games and they are last in the AL Central standings. The Chicago pitching staff has a 4.25 ERA with a 1.37 WHIP and a .248 opponent batting average, while the offense has scored 621 runs with a .232 batting average and a .301 on base percentage this season. Lenyn Sosa has led Chicago with 21 home runs and 72 RBIs, while Andrew Benintendi has added 20 home runs and 63 RBIs this year. The projected starting pitcher for Chicago is Davis Martin, who is 7-10 with a 4.03 ERA and a 1.27 WHIP over 138.1 innings pitched this season. 

Why the Yankees will beat the White Sox

• The White Sox have lost each of their last nine games after playing the previous day.
• The Yankees have won each of their last six home games against the White Sox.
• The White Sox have failed to cover the run line in each of their last 10 Thursday night road games against AL East opponents.
• The Yankees have covered the run line in five of their last six home games against the White Sox.
• The Yankees have led after 3 innings in each of their last 10 home games against opponents that held a losing record.
• The White Sox have trailed after 5 innings in each of their last seven games at Yankee Stadium.

Total Runs Facts

• Seven of the White Sox’s last eight games as underdogs against American League opponents have gone UNDER the total runs line.
• Five of the Yankees’ last six games have gone UNDER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in six of the White Sox’s last seven night games at Yankee Stadium.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in nine of the last 11 games between the White Sox and Yankees at Yankee Stadium.

New York Yankees Player Prop Facts

• Aaron Judge has hit at least one home run in three of the Yankees’ last four games against the White Sox.
• Anthony Volpe has recorded at least one hit in each of his last 14 appearances against AL Central opponents that held a losing record.
• Carlos Rodon has recorded a win in six of his last seven home appearances against AL opponents that held a losing record.
• Anthony Volpe has recorded a Double in three of the Yankees’ last four home games against the White Sox.

Chicago White Sox Player Prop Facts

• Miguel Vargas has recorded a hit in each of his eight previous appearances against the Yankees.
• Andrew Benintendi has hit a home run in two of his last three appearances against AL East opponents.

Yankees vs White Sox Prediction 

New York continues to pile up wins and they are now tied with Toronto in the AL East standings. The Yankees are 46-31 at home this year, while the White Sox are 25-52 on the road. Chicago has scored two runs or fewer in three straight games and they are going against Rodon, who has allowed two earned runs or fewer in five straight outings. New York is facing Martin, who has allowed three earned runs or fewer in five straight. The Yankees are on fire right now and I am not going against them. Take New York by at least two runs here.