Angels vs Astros Prediction 9/26/25 MLB Picks Today

The Houston Astros and Los Angeles Angels meet Friday in MLB action at Angel Stadium. Here’s a Angels vs Astros Prediction. This article will include a Angels vs Astros Pick.

Houston Astros Betting Preview

The Houston Astros are 85-74 on the year after playing the Athletics. The Houston Astros are batting .250 on the season, have a .316 OBP, and a .396 slugging percentage. The Houston Astros pitching staff has a 3.89 ERA and a 1.23 WHIP. Jose Altuve leads the Houston Astros with 155 hits and 77 RBI while Jeremy Pena and Christian Walker have combined for 286 hits and 147 RBI.

Jason Alexander gets the ball for the Houston Astros, and he is 4-2 with a 4.83 ERA and 61 strikeouts this season. This will be Alexander’s first career game against the Los Angeles Angels.

Los Angeles Angels Betting Preview

The Los Angeles Angels are 71-88 on the year after playing the Royals. The Los Angeles Angels are batting .226 on the season, have a .298 OBP, and a .398 slugging percentage. The Los Angeles Angels pitching staff has a 4.89 ERA and a 1.44 WHIP. Taylor Ward leads the Los Angeles Angels with 131 hits and 103 RBI while Zach Neto and Nolan Schanuel have combined for 258 hits and 115 RBI.

Kyle Hendricks gets the ball for the Los Angeles Angels, and he is 8-10 with a 4.79 ERA and 106 strikeouts this season. Hendricks is 1-1 with a 3.91 ERA and 12 strikeouts in his career against the Houston Astros.

Houston Astros @ Los Angeles Angels Betting Trends: September 26, 2025

• Probable Starting Pitcher: Kyle Hendricks      Record this season: 8-10      ERA: 4.79
• Home Record: 5-5
• Last 5 against Astros: 1-1

Why the Los Angeles Angels will win

• The Angels have won seven of their last eight games as home underdogs against American League opponents following a home loss.
• The Astros have lost 10 of their last 12 games as favorites against American League opponents following a win.
• The Angels have covered the run line in each of their last 13 games as underdogs against American League opponents following a home loss.
• The Astros have failed to cover the run line in 11 of their last 12 night games against AL West opponents that held a losing record.
• The Astros have trailed after 3 innings in four of their last five night games.
• The Astros have trailed after 5 innings in each of their last five night games.

• Probable Starting Pitcher: Jason Alexander      Record this season: 4-2      ERA: 4.83
• Road Record: 4-0
• Last 5 against Angels: –

Why the Houston Astros will win

• The Astros have won each of their last 16 Friday games against the Angels.
• The Angels have lost each of their last eight Friday games.
• The Angels have failed to cover the run line in eight of their last nine games as underdogs.
• The Astros have covered the run line in seven of their last eight night games following a road win.
• The Angels have trailed after 3 innings in three of their last four games against American League opponents.
• The Angels have trailed after 5 innings in five of their last six games against American League opponents.
• The Angels have lost the first inning in four of their last five games against American League opponents.

Total Runs Facts

• Six of the Astros’ last seven road games against American League opponents have gone UNDER the total runs line.
• Five of the Angels’ last six home games against AL West opponents have gone OVER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the last six games between the Astros and Angels.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in nine of the Astros’ last 11 road games against AL West opponents.

Los Angeles Angels Player Prop Facts

• Taylor Ward has hit a home run in each of his last three appearances in night games.
• Kyle Hendricks has recorded five or more strikeouts in each of his last three appearances.
• Luis Rengifo has recorded at least one hit in each of his last 10 appearances against the Astros after playing the previous day.
• Kyle Hendricks has recorded a win in three of his last four home appearances against AL opponents that held a winning record.
• Jo Adell ranks T8th in the league in Home Runs (37) this season.

Houston Astros Player Prop Facts

• Isaac Paredes has hit a home run in four of his last five appearances with the Astros as favorites against the Angels.
• Christian Walker has recorded at least one hit in each of the Astros’ last 19 road games against opponents that held a losing record.
• Christian Walker has recorded a Double in three of the Astros’ last four games as road favorites against AL West opponents.

Matchup/League Facts

• The Angels rank 30th in the league for doubles this season (209).
• The Angels rank 30th in the league for batting average this season (.226).
• The Astros rank 1st in the league for strikeouts this season (1480).
• The Astros rank T26th in the league for triples this season (12).

Angels vs Astros Prediction

If you’re looking for the Angels to play spoiler, they’ve won 2 games since September 11. Hendricks has been hittable all season with a 4.79 ERA, and he’s allowed 20 hits and 11 runs in his last 23.1 innings. Alexander isn’t the most trustworthy pitcher in his own right, allowing 21 hits and 11 earned runs in his last 18 innings, but the bottom line is the Astros need wins to stay in the wild card hunt.

The Astros are a veteran team that knows how to win this time of year, and anything but a win here would be disappointing. Bad pitching matchup, but I’m siding with the Astros to keep their season alive.