Chargers vs Colts Prediction 10/19/25 NFL Picks Today

Indianapolis Colts (5-1) vs. LA Chargers (4-2)
October 19, 2025 4:05 pm EDT
The Line: LA Chargers -1.5; Over/Under: 48
(Get latest betting odds)

In this article we will formulate a Chargers vs Colts prediction for this NFL game on Sunday, October 19th at SoFi Stadium in Inglewood, California. Let’s take a look at the prediction for this week 7 matchup.

Los Angeles Chargers Betting Preview

The Los Angeles Chargers are 4-2 this season after they defeated Miami by a score of 29-27 last week. Los Angeles trailed 13-9 at halftime and 27-26 with under a minute left, but they rallied and won on a field goal in the final seconds. The Chargers out gained Miami by a total of 403-341, went 6-15 on third downs, and won the turnover battle by a margin of 3-1 in the game. Justin Herbert went 29-38 for 264 yards and two touchdowns, while Kimani Vidal rushed 18 times for 124 yards in the game. Ladd McConkey led the receivers with seven receptions for 100 yards and one score in the win. The LA defense recorded two sacks and four tackles for loss in the game.

Los Angeles also has wins against the Broncos, Raiders, and Chiefs, but they did lose to the Commanders and Giants. The Chargers have lost two of their last three games and they are currently tied for first in the AFC West standings. Los Angeles has scored 21.2 points per game with 240.0 passing yards and 120.7 rushing yards per game, while they have allowed 20.8 points against per game this season. Justin Herbert has thrown for 1,493 yards, 10 touchdowns, and four interceptions, while Keenan Allen has caught 33 passes for 316 yards and three scores this season.

Indianapolis Colts Betting Preview

The Indianapolis Colts are 5-1 this year after they defeated Arizona by a score of 31-27 in their last game. Indianapolis led 14-10 at halftime, but they trailed 27-24 in the fourth quarter, before they scored the winning touchdown with about four minutes left. The Colts were out gained by a total of 400-355, went 4-8 on third downs, and tied the turnover battle at one in the game. Daniel Jones went 22-30 for 212 yards, two touchdowns, and one interception, while Jonathan Taylor rushed 21 times for 123 yards and one score. Tyler Warren led the receivers with six receptions for 63 yards and one touchdown in the win. The Indianapolis defense recorded two sacks and six tackles for loss in the game.

Indianapolis also has wins against the Raiders, Titans, Broncos, and Dolphins, but they have one loss against the Rams so far this year. The Colts have won two games in a row and they are currently first in the AFC South standings. Indianapolis has scored 32.3 points per game with 245.0 passing yards and 131.8 rushing yards per game, while they have allowed 19.3 points against per game this season. Daniel Jones has thrown for 1,502 yards, eight touchdowns, and three interceptions, while Jonathan Taylor has rushed for 603 yards and seven scores this year.

Why the Indianapolis Colts will win

The Colts have won each of their last six games against AFC opponents.
The Chargers have lost three of their last four games as favorites against AFC South opponents.
The Colts have covered the spread in each of their last six October games against AFC opponents.
The Chargers have failed to cover the spread in five of their last six Week 7 games.
The Colts have won the first quarter in five of their last six October games as underdogs against AFC opponents.
The Colts have scored the first touchdown in each of their last eight games as road underdogs.
The Colts have won the first half in six of their last seven games against AFC opponents.

Total Points Facts

Eight of the Colts’ last nine Sunday games played on the West Coast have gone OVER the total points line.
Each of the Chargers’ last five home games in October have gone UNDER the total points line.
Each of the last four Sunday games at SoFi Stadium have gone UNDER the total points line.

Los Angeles Chargers Player Prop Facts

Ladd McConkey has scored at least one touchdown in each of the Chargers’ last three October games.
Justin Herbert has recorded 259+ passing yards in each of the Chargers’ last four Week 7 games.
Justin Herbert has recorded 20+ rushing yards in five of the Chargers’ last six October home games.
Justin Herbert has recorded 24+ completions in seven of the Chargers’ last eight regular season games against AFC South opponents.
Ladd McConkey has recorded 74+ rushing and receiving yards in eight of his last 10 appearances against AFC opponents.
Will Dissly has recorded 24+ receiving yards in each of his last five appearances at SoFi Stadium.
Heading into Week 7, Tuli Tuipulotu has recorded the most sacks in a single game this season (4.0 vs Giants, Week 4).

Indianapolis Colts Player Prop Facts

Tyler Warren has scored the first touchdown in each of the Colts’ last three games.
Daniel Jones has recorded 236+ passing yards in each of his last four appearances with his team as a road underdog.
Daniel Jones has recorded 20+ rushing yards in each of his five previous Week 7 appearances.
Daniel Jones has recorded 22+ completions in each of his last six appearances with his team as an underdog following a win.
Jonathan Taylor has scored at least one touchdown in eight of his last nine appearances following a home win.
Jonathan Taylor has recorded 108+ rushing and receiving yards in seven of his last eight appearances following a home win.
Jonathan Taylor has scored the last touchdown in each of the Colts’ last three October games.
Michael Pittman Jr. has recorded 58+ receiving yards in each of the Colts’ last four Week 7 games.
Heading into Week 7, Jonathan Taylor ranks 1st in the NFL in rushing yards (603) this season.

Matchup/League Facts

Chargers – three different players have recorded 60+ rushing yards in a game this season – equal-most in the NFL, heading into Week 7.
Chargers – two different players have recorded 80+ rushing yards in a game this season – equal-most in the NFL, heading into Week 7.
Colts – seven different players have recorded 50+ receiving yards in a game this season – equal-most in the NFL, heading into Week 7.
Heading into Week 7, the Colts rank 1st in the NFL in points per game (32.3) this season.