Iowa vs USC Prediction 11/15/25 College Football Picks Today

In this article, we will formulate a Iowa vs USC Prediction for this College Football Week 12 game on Saturday, November 15^th. Let’s take a look at the prediction for this College Football matchup.

USC Trojans Preview

USC has a 7-2 record this season and is sitting 3rd in the Big Ten. They are 5-4 ATS, 5-4 in Over/Under and have a 5-0 home record and a 2-2 away record. USC is coming off a 38-17 home win against Northwestern and will face Iowa and Oregon next.

Offensively, USC averages 39.6 points per game, ranking 7th in the nation, while defensively, they allow 21.8 points per game, which is 45th. USC averages 503.2 total yards per game (303.0 passing and 200.2 rushing), while allowing 346.8 total yards per game (141.7 rushing and 205.1 passing).

Jayden Maiava leads USC with 2,614 passing yards with 66.2% completed passes and 17 touchdowns. King Miller leads the team in rushing yards with 636, while Makai Lemon has a team-high 61 receptions for 937 receiving yards. Defensively, Eric Gentry has a team-high 61 total tackles (44 of them solo), while Kameryn Crawford leads the team in sacks, with 3.5, and Bishop Fitzgerald has a team-high 5 interceptions.

Iowa Hawkeyes Preview

Iowa has a 6-3 record this season and is sitting 6th in the Big Ten. They are 6-2-1 ATS, 4-4-1 in Over/Under and have a 4-2 home record and a 2-1 away record. Iowa is coming off a 16-18 home loss against Oregon and will face USC, Michigan State and Nebraska next.

Offensively, Iowa averages 29.6 points per game, ranking 61st in the nation, while defensively, they allow 13.7 points per game, which is 5th. Iowa averages 309.1 total yards per game (133.2 passing and 175.9 rushing), while allowing 250.2 total yards per game (103.6 rushing and 146.7 passing).

Mark Gronowski leads Iowa with 1,084 passing yards with 63.9% completed passes and 5 touchdowns. Kamari Moulton leads the team in rushing yards with 522, while Sam Phillips has a team-high 13 receptions for 216 receiving yards. Defensively, Karson Sharar has a team-high 56 total tackles (24 of them solo), while Max Llewellyn leads the team in sacks, with 6, and Zach Lutmer has a team-high 2 interceptions.

Iowa Hawkeyes @ USC Trojans Betting Trends: Week 12

Why the USC Trojans will win

• Iowa has lost each of its last 11 games against AP-ranked teams.
• USC has won each of its last nine games against non-AP-ranked teams.
• USC has covered the spread in nine of its last 10 games as a favorite in California.
• Iowa has failed to cover the spread in 10 of its last 12 games against AP-ranked teams.
• USC has won the first half in five of its last six home games against conference opponents.

Why the Iowa Hawkeyes will win

• Iowa has won each of its last four November games as a road underdog.
• Iowa has covered the spread in each of its last seven November games as an underdog.
• USC has failed to cover the spread in three of its last four games against non-AP-ranked teams.
• Iowa has won the first quarter in three of its last four road games against conference opponents.

Total Points Facts

• Twelve of Iowa’s last 13 games as an underdog have gone UNDER the total points line.
• Each of USC’s last four home games against non-AP-ranked teams have gone OVER the total points line.

USC Trojans Player Prop Facts

• Heading into Week 12, Bishop Fitzgerald ranks T1st amongst FBS players for interceptions (5) this season.

Iowa Hawkeyes Player Prop Facts

• Heading into Week 12, Kaden Wetjen is the only player in the FBS to have both a punt and kick return touchdown this season.

Matchup/League Facts

• USC ranks 2nd among FBS teams for yards per game this season (503.2).
• USC ranks 2nd among FBS teams for red zone percentage against this season (64.3).
• Iowa ranks 1st among FBS teams for 4th down conversion percentage against this season (21.4).
• Iowa ranks 2nd among FBS teams for H2 opponent points per game this season (4.3).

Iowa vs USC Prediction

In this Iowa vs USC Prediction, USC is coming as -6.5-point home favorites, with the total set at 49.5 points. Both teams have been very good this season and are both coming into this matchup in very good form. USC is 3-1 in its last 4 games and have been undefeated in their five home games, while Iowa is 5-2 in its last 7 games and 6-1 against the spread. USV has the 6^th-best offense in the country and are going up against Iowa’s 5^th-best defense, so I expect a hard-fought battle and a tight game. Take Iowa to keep this one close and get the +6.5 points.