Northwestern vs DePaul Prediction 11/14/25 College Basketball Picks Today

In this article, we will formulate a Northwestern vs DePaul Prediction for this College Basketball game on Friday, November 14^th. Let’s take a look at the prediction for this College Basketball matchup.

DePaul Blue Demons Preview

DePaul has a 2-1 record this season and are tied for 6th place in the Big East conference. They are 1-2 ATS, 1-2 in Over/Under and have a 2-1 home record and a 0-0 away record. DePaul is coming off a 53-66 home loss against Buffalo and will face Gardner-Webb, Detroit Mercy and Georgia Tech next.

Offensively, DePaul averages 72.3 points per game, which ranks 276th in the nation, while defensively, they allow 64.0 points per game (69th). The Blue Demons shoot with 40.5% from the field (310th), and with 29.7% from beyond the arc (259th). They shoot with 61.1% from the free throw line (334th), and grab 40.3 rebounds per game (139th), while dishing out 16 assists per game (150th) and committing 13.3 turnovers per game (208th).

CJ Gunn leads DePaul in scoring, with an average of 15.7 points and 4.3 rebounds. N.J. Benson follows with 14.3 points and 9.3 rebounds per game, while Layden Blocker adds 8 points and 4.3 assists per game.

Northwestern Wildcats Preview

Northwestern has a 3-0 record this season and are tied for 1st place in the Big Ten conference. They are 2-1 ATS, 1-2 in Over/Under and have a 3-0 home record and a 0-0 away record. Northwestern is coming off a 110-63 home win against Cleveland State and will face Virginia, South Carolina and Oklahoma State next.

Offensively, Northwestern averages 85.3 points per game, which ranks 129th in the nation, while defensively, they allow 54.0 points per game (10th). The Wildcats shoot with 50.6% from the field (56th), and with 39.0% from beyond the arc (72nd). They shoot with 69.9% from the free throw line (206th), and grab 41.7 rebounds per game (109th), while dishing out 19.7 assists per game (41st) and committing 8 turnovers per game (13th).

Nick Martinelli leads Northwestern in scoring, with an average of 19.3 points and 7 rebounds. Arrinten Page follows with 14 points and 9.3 rebounds per game, while Jayden Reid adds 10.3 points and 6.3 assists per game.

Northwestern Wildcats @ DePaul Blue Demons Betting Trends: November 14, 2025

Why the DePaul Blue Demons will win

• DePaul has won 12 of its last 13 home games against non-Conference opponents.
• Northwestern has lost three of its last four night games against the Big East Conference.
• DePaul has won the first half in seven of its last eight home night games against non-Conference opponents.

Why the Northwestern Wildcats will win

• Northwestern has won each of its last 11 Friday games against non-Conference opponents.
• DePaul has lost 14 of its last 15 night games following a home loss.
• Northwestern has won the first half in each of its last nine games against non-AP-ranked opponents.

Total Points Facts

• Each of Northwestern’s last six Friday night games against non-Conference opponents have produced a total of 137 or fewer points.
• Ten of DePaul’s last 12 home games against non-Conference opponents have produced a total of 142+ points.

Northwestern vs DePaul Prediction

In this Northwestern vs DePaul Prediction, Northwestern is coming as -4.5 road favorites. Northwestern has been perfect this season, having won all of its three games played, but are playing their first road game of the season, while DePaul is coming off its first defeat of the season. Both teams have been elite defensively so far, sitting on the top-70 of the country in points allowed, with 118 points per game combined, as Northwestern has the 10^th-best defense in the nation. Both teams have been playing mostly low-scoring games this season as they are 4-2 to the under combined, so take the under the total once again in this one.