Arizona State vs Colorado Prediction Football Picks Today 11/22/25
Arizona State Sun Devils (7-3) vs. Colorado Buffaloes (3-7)
November 22, 2025 8:00 pm EDT
The Line: Colorado Buffaloes 220 / Arizona State Sun Devils -270; Over/Under: 48.5
(Get latest betting odds)
In this article, we will formulate an Arizona State vs Colorado Prediction for this College Football Week 13 game on Saturday, November 22nd. Let’s take a look at the prediction for this College Football matchup.
Colorado Buffaloes Preview
Colorado has a 3-7 record this season and is sitting 15th in the Big 12. They are 3-6-1 ATS, 4-5-1 in Over/Under and have a 3-3 home record and a 0-4 away record. Colorado is coming off a 29-22 road loss against West Virginia and will face Kansas State next.
Offensively, Colorado averages 22 points per game, ranking 108th in the nation, while defensively, they allow 30.0 points per game, which is 107th. Colorado averages 331.8 total yards per game (209.7 passing and 122.1 rushing), while allowing 420.7 total yards per game (210.9 rushing and 209.8 passing).
Kaidon Salter leads Colorado with 1,242 passing yards with 63.1% completed passes and 10 touchdowns. Micah Welch leads the team in rushing yards with 313, while Omarion Miller has a team-high 34 receptions for 652 receiving yards. Defensively, Tawfiq Byard has a team-high 78 total tackles (51 of them solo), while Keaten Wade leads the team in sacks, with 2.5.
Arizona State Sun Devils Preview
Arizona State has a 7-3 record this season and is sitting 5th in the Big 12. They are 5-5 ATS, 3-7 in Over/Under and have a 5-1 home record and a 2-2 away record. Arizona State is coming off a 25-23 home win against West Virginia and will face Arizona next.
Offensively, Arizona State averages 24.7 points per game, ranking 86th in the nation, while defensively, they allow 23.6 points per game, which is 62nd. Arizona State averages 400.6 total yards per game (219.4 passing and 181.2 rushing), while allowing 343.4 total yards per game (117.7 rushing and 225.7 passing).
Sam Leavitt leads Arizona State with 1,628 passing yards with 60.7% completed passes and 10 touchdowns. Raleek Brown leads the team in rushing yards with 823, while Jordyn Tyson has a team-high 57 receptions for 628 receiving yards. Defensively, Keyshaun Elliot has a team-high 82 total tackles (44 of them solo), while Keyshaun Elliot leads the team in sacks, with 5, and Keith Abney II, Martell Hughes have a team-high 2 interceptions each.
Arizona State Sun Devils @ Colorado Buffaloes Betting Trends: Week 13
Why the Colorado Buffaloes will win
- Colorado has won five of its last six November games as a home underdog against non-AP-ranked teams.
- Colorado has covered the spread in nine of its last 10 games against conference opponents at Folsom Field.
- Arizona State has failed to cover the spread in each of its last four games at Folsom Field.
- Colorado has won the first quarter in five of its last six games against conference opponents at Folsom Field.
Why the Arizona State Sun Devils will win
- Colorado has lost each of its last 11 November games as an underdog.
- Arizona State has won each of its last seven games in November.
- Colorado has failed to cover the spread in each of its last six games as an underdog against non-AP-ranked teams.
- Arizona State has covered the spread in each of its last five road games in November.
- Colorado has lost the first half in each of its last four games against conference opponents.
Total Points Facts
- Ten of Colorado’s last 11 games as an underdog against teams from Arizona have gone OVER the total points line.
- Seven of Arizona State’s last eight November games as a road favorite have gone OVER the total points line.
Colorado Buffaloes Player Prop Facts
- Heading into Week 13, Quentin Gibson ranks 3rd amongst FBS players for kick return yards (542) this season.
Arizona State Sun Devils Player Prop Facts
- Jordyn Tyson has recorded 5+ receptions in 15 consecutive games – longest streak in the FBS, heading into Week 13.
Matchup/League Facts
- Colorado ranks T134th among FBS teams for Q2 opponent points per game this season (11.7).
- Colorado ranks 133rd among FBS teams for rushing yards allowed per game this season (210.9).
- Arizona State has recorded the equal-most home wins by a margin of five points or less of any FBS team this season (3).
- Six of Arizona State’s 10 games this season have been decided by a margin of seven points or less – equal-most amongst FBS teams.
Arizona State vs Colorado Prediction
In this Arizona State vs Colorado Prediction, Arizona State is coming as -7-point home favorites, with the total set at 49 points. Arizona State has been the better team this season with more than twice overall wins than Colorado and are 3-1 in its last 4 games, while Colorado is 1-5 in its last 6 games and has been mediocre at home this season. Arizona State has been better both offensively and defensively and I expect them to get the job done on the road today. Take Arizona State and lay the points.