West Virginia vs Clemson Prediction 11/21/25 College Basketball Picks Today

 In this article, we will formulate a West Virginia vs Clemson Prediction for this College Basketball game on Friday, November 21^st. Let’s take a look at the prediction for this College Basketball matchup.

Clemson Tigers Preview

Clemson has a 4-1 record this season and are in 11th place in the ACC conference. They are 2-3 ATS, 2-3 in Over/Under and have a 4-0 home record and a 0-1 away record. Clemson is coming off an 81-61 home win against North Alabama and will face Alabama A&M, Alabama and Brigham Young next.

Offensively, Clemson averages 84.6 points per game, which ranks 108th in the nation, while defensively, they allow 58.6 points per game (8th). The Tigers shoot with 46.2% from the field (168th), and with 32.2% from beyond the arc (232nd). They shoot with 73.1% from the free throw line (126th), and grab 42.6 rebounds per game (70th), while dishing out 17.8 assists per game (64th) and committing 7.2 turnovers per game (1st).

Carter Welling leads Clemson in scoring, with an average of 11.4 points and 6 rebounds. Ace Buckner follows with 11 points and 4 rebounds per game, while RJ Godfrey adds 10.8 points and 6 rebounds per game.

West Virginia Mountaineers Preview

West Virginia has a 5-0 record this season and are in 1st place in the Big 12 conference. They are 2-3 ATS, 1-4 in Over/Under and have a 5-0 home record and a 0-0 away record. West Virginia is coming off an 81-59 home win against Lafayette and will face Mercyhurst, Coppin State and Wake Forest next.

Offensively, West Virginia averages 72.8 points per game, which ranks 281st in the nation, while defensively, they allow 54.8 points per game (3rd). The Mountaineers shoot with 44.8% from the field (214th), and with 34.7% from beyond the arc (141st). They shoot with 69.0% from the free throw line (229th), and grab 34.6 rebounds per game (312th), while dishing out 13.0 assists per game (260th) and committing 9.8 turnovers per game (40th).

Honor Huff leads West Virginia in scoring, with an average of 17.2 points. Brenen Lorient follows with 12.8 points and 7 rebounds per game, while DJ Thomas adds 11 points per game.

West Virginia Mountaineers @ Clemson Tigers Betting Trends: November 21, 2025

Why the Clemson Tigers will win

• Clemson has won each of its last nine night games against non-AP-ranked opponents.
• West Virginia has lost each of its last seven games against non-AP-ranked opponents at a neutral venue.
• Clemson has won the first half in each of its last 12 night games against non-AP-ranked opponents.

Why the West Virginia Mountaineers will win

• West Virginia has won each of its last nine games against non-Conference opponents.
• Clemson has lost three of its last four games at TD Arena.
• West Virginia has won the first half in each of its last 10 games against non-AP-ranked opponents.

West Virginia vs Clemson Prediction

In this West Virginia vs Clemson Prediction, Clemson is coming as -3.5 home favorites. Both teams have been elite this season, as Clemson has lost only once in its 5 games played, while West Virginia has been undefeated this season. Both teams have been playing elite defense, ranking on the top-8 of the country in points allowed, with just 113.4 points per game combined. As a result, they are 7-3 to the under combined this season and I expect a defensive-minded low-scoring grind today. Take the under 133.5 points.