Michigan State vs Duke Prediction 12/6/25 College Basketball Picks Today

In this article we will formulate a Michigan State vs Duke prediction for this College Basketball game on Saturday, December 6th at the Breslin Center in East Lansing, Michigan. Let’s take a look at the prediction for this College Basketball matchup.

Michigan State Spartans Betting Preview

The Michigan State Spartans are 8-0 this season after they defeated Iowa by a score of 71-52 in their last game. Michigan State led 35-21 at halftime and added 36 points in the second half for the easy win. The Spartans shot 50% from the field, 25% on three pointers, and 88% on free throws in the game. Coen Carr led MSU with 15 points and five rebounds, while Jeremy Fears Jr added 14 points and six assists in the win. 

Prior to that game, Michigan State defeated North Carolina by a score of 74-58 and East Carolina by a score of 89-56. The Spartans have scored 78.6 points per game with 41.6 rebounds and 19.4 assists per game, while they have allowed 60.4 points against per game this season. Jaxon Kohler is averaging 14.3 points and 9.9 rebounds per game, while Jeremy Fears Jr is averaging 12.3 points and 9.4 assists per game for the Spartans. Michigan State is shooting 47.4% from the field, 72.9% on free throws, and 33.3% on three pointers this season. 

Duke Blue Devils Betting Preview

The Duke Blue Devils are 9-0 this year after they defeated Florida by a score of 67-66 in their last game. Duke led 36-24 at halftime, but they were outscored 42-31 in the second half in the close win. The Blue Devils shot 45% from the field, 27% on three pointers, and 63% on free throws in the game. Cameron Boozer led Duke with 29 points and six rebounds, while Isaiah Evans added 13 points and one rebound in the win. 

Prior to that game, Duke defeated Arkansas by a score of 80-71 and Howard by a score of 93-56. The Blue Devils have scored 89.1 points per game with 42.0 rebounds and 19.4 assists per game, while they have allowed 59.5 points against per game this season. Cameron Boozer is averaging 23.6 points and 9.3 rebounds per game, while Patrick Ngongba II is averaging 12.6 points and 6.3 rebounds per game for the Blue Devils. Duke is shooting 51.2% from the field, 71.6% on free throws, and 36.0% on three pointers this year. 

Why the Michigan State Spartans will win

• Michigan State has won each of its last 17 games against non-Conference opponents at Jack Breslin Student Events Center.
• Duke has lost four of its last five day games against Top 10 AP-ranked opponents.
• Michigan State has won the first half in each of its last 18 Saturday day games against non-Conference opponents.

Why the Duke Blue Devils will win

• Duke has won each of its last 12 day games.
• Michigan State has lost each of its last eight games against Top 5 AP-ranked opponents.
• Duke has won the first half in 18 of its last 19 games against non-Conference opponents.

Total Points Facts

• Twelve of Michigan State’s last 13 day games against non-Conference opponents at Jack Breslin Student Events Center have produced a total of 142+ points.
• Each of Duke’s last six day games have produced a total of 142+ points.

Michigan State vs Duke Prediction 

Both of these teams come into this matchup with undefeated records and they are ranked in the top seven, so this should be a great battle. Michigan State has held their last four opponents to 58 points or fewer and they are shooting 47% from the field. Duke is shooting 51% from the field, but played a very poor second half against Florida last time out. I think MSU’s defense is going to be a big factor in this game, as Duke is still trying to find consistent scoring other than Boozer. Take the Spartans to win at home.