Dallas Cowboys vs LA Chargers Prediction 12/21/25 NFL Picks Today

The Los Angeles Chargers and the Dallas Cowboys meet in week 16 NFL action from AT&T Stadium on Sunday. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Los Angeles Chargers vs. Dallas Cowboys prediction.

Los Angeles Chargers Recap

The Los Angeles Chargers come into this game looking to add on to their 16-13 win over the Kansas City Chiefs last time out to sit at 10-4 on the year. After this game, the Chargers will head home for a game against the Houston Texans. 

Chargers Win 3 Straight & 6 Of Last 7

Justin Herbert has thrown for 3,191 yards, 23 touchdowns and 12 interceptions on 65.6% passing while Kimani Vidal also has 620 rushing yards and 3 TDs as well this season. Omarion Hampton has 431 rushing yards and Ladd McConkey leads the Chargers with 715 receiving yards coming on 61 catches with 5 TDs while Keenan Allen has a team-high 68 catches for 680 yards and 4 TDs. Quentin Johnston has 533 receiving yards with 7 TDs and Oronde Gadsden II has 43 catches for 602 yards as well. On defense, Daiyan Henley has a team-high 86 total tackles including 48 solo tackles. Tuli Tuipulotu has a team-high 12 sacks while Donte Jackson and Tony Jefferson each have a team-high 4 interceptions. As a group, the Chargers’ defensive unit has combined for 40 sacks and 17 interceptions so far this season. 

Why the Los Angeles Chargers will win

• The underdogs have won each of the Cowboys’ last four games at AT&T Stadium.
• The Cowboys have lost three of their last four Sunday games as favorites.
• The Chargers have covered the spread in each of their last eight games as road underdogs against NFC opponents.
• The Cowboys have failed to cover the spread in each of their last six December games against AFC opponents.

Los Angeles Chargers Player Prop Facts

• Omarion Hampton has scored a touchdown in three of his last four appearances following a win.
• Omarion Hampton has recorded 56+ rushing yards in each of his last four appearances following a win.
• Oronde Gadsden II has recorded 41+ receiving yards in each of the Chargers’ last four road games.
• Omarion Hampton has recorded 65+ rushing and receiving yards in each of his last five appearances.
• Heading into Week 16, Kimani Vidal ranks 1st in the league amongst qualified players for broken tackle percentage (73.5%) this season.

Dallas Cowboys Recap

The Dallas Cowboys come into this game looking to bounce back from their 34-26 loss to Minnesota last time out to sit at 6-7-1 this season. After this game, Dallas will head on the road for a game against the Washington Commanders.

Cowboys Playoff Hopes On Life Support

Dak Prescott has thrown for 3,931 yards, 26 touchdowns and 10 interceptions on 68.4% passing while Javonte Williams leads the Cowboys in rushing with 1,113 rushing yards and 10 touchdowns so far this season. George Pickens leads the Cowboys in receiving with 81 catches, 1,212 yards and 8 touchdowns while Jake Ferguson has 77 catches for 570 yards and 7 TDs. CeeDee Lamb has 63 grabs for 976 yards while Ryan Flournoy has 389 receiving yards with 3 TDs and KaVontae Turpin has 296 receiving yards. Three more Cowboys have 100+ receiving yards as well on the year. On defense, Kenneth Murray Jr. has a team-high 74 total tackles including 36 solo tackles while James Houston has a team-high 5.5 sacks and the Cowboys’ defense as a whole has combined for 29 sacks and 6 interceptions so far this season. 

Why the Dallas Cowboys will win

• The home team has won each of the Cowboys’ last seven Week 16 games.
• The Chargers have lost six of their last seven road games following a road win.
• The home team has covered the spread in each of the Cowboys’ last six Week 16 games.
• The Chargers have failed to cover the spread in four of their last five road games.

Dallas Cowboys Player Prop Facts

• Malik Davis has scored a touchdown in each of the Cowboys’ last two home games.
• George Pickens has recorded 68+ receiving yards in six of the Cowboys’ last seven home games.
• Dak Prescott has recorded 24+ completions in each of his last five home appearances against AFC opponents.
• Dak Prescott has recorded 255+ passing yards in each of the Cowboys’ last 11 Sunday games as home favorites.
• Dak Prescott has recorded 11+ rushing yards in each of his last five December appearances against AFC opponents.
• George Pickens has recorded 68+ rushing and receiving yards in six of the Cowboys’ last seven home games.
• Heading into Week 16, Dak Prescott ranks 1st in the NFL in passing yards (3931) this season.

Total Points Facts

• Each of the Chargers’ last seven Sunday games as underdogs have gone UNDER the total points line.
• Seven of the Cowboys’ last eight Sunday games as favorites have gone OVER the total points line.
• Four of the last five Sunday games at AT&T Stadium have gone OVER the total points line.

Los Angeles Chargers vs. Dallas Cowboys Prediction

I’m on the Chargers here. I think if the Chargers had nothing to play for here, you could maybe consider Dallas here, but the problem for the Cowboys is that they’ve had a couple of chances to get back into the playoff chase in must-win spots the last couple of weeks that were easier than what they’re up against here, and have fallen flat in those games as well. Los Angeles keeps on finding ways to win and grinding out positive results, and I think that the Cowboys are in some trouble here. Give me the Chargers.