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White Sox vs Royals Prediction 5/13/26 MLB Picks Today

Kansas City Royals (19-23) vs. Chicago White Sox (20-21)
May 13, 2026 7:40 pm EDT
The Line: Chicago White Sox -105 / Kansas City Royals -115; Over/Under: 8
(Get latest betting odds)

In this article we will formulate a White Sox vs Royals prediction for this MLB game on Wednesday, May 13th at Rate Field in Chicago, Illinois. Let’s take a look at the prediction for this MLB matchup. 

Chicago White Sox Betting Preview

The Chicago White Sox are 20-21 this year after they won game one by a score of 6-5 on Tuesday night. Chicago blew a 5-2 lead in the sixth inning, but they scored in the eighth to get the win. The White Sox recorded seven hits in the game and they were led by Meidroth, who went 1-4 with one home run and three RBIs. Fedde allowed six hits and two earned runs over 5.0 innings, while Dominguez got the win and Hudson picked up the save. Prior to this series, Chicago won two out of three against the Mariners, but lost two out of three against the Angels before that. 

This season, Chicago has a 4.26 ERA with a 1.36 WHIP and a .242 opponent batting average, while they have scored 177 runs with a .231 batting average and a .321 on base percentage. Munetaka Murakami has led the White Sox with 15 home runs and 29 RBIs, while Colson Montgomery has added 10 home runs and 28 RBIs. The projected starting pitcher for Chicago is Noah Schultz, who is 2-2 with a 4.68 ERA and a 1.32 WHIP over 25.0 innings pitched this year. 

Kansas City Royals Betting Preview

The Kansas City Royals are 19-23 this season after they lost game one by a score of 6-5 last night. Kansas City led 2-0 in the first inning, but they allowed six of the last nine runs for the loss. The Royals recorded 11 hits and they committed one error in the game, while they were led by Loftin, who went 1-2 with two RBIs. Kolek allowed five hits and five earned runs over 4.2 innings, while Strahm picked up the loss in relief. Prior to this series, Kansas City won two out of three against the Tigers and split four games with the Guardians. 

This season, Kansas City has a 4.33 ERA with a 1.36 WHIP and a .235 opponent batting average, while they have scored 174 runs with a .242 batting average and a .319 on base percentage. Bobby Witt has led the Royals with six home runs and 20 RBIs, while Salvador Perez has added five home runs and 17 RBIs. The projected starting pitcher for Kansas City is Seth Lugo, who is 1-2 with a 3.21 ERA and a 1.36 WHIP over 47.2 innings pitched this season. 

Why the Chicago White Sox will win

  • The White Sox have won seven of their last eight games as underdogs against American League opponents.
  • The Royals have lost each of their last six road games against AL Central opponents.
  • The White Sox have covered the run line in each of their last 13 home games against American League opponents following a home win.
  • The Royals have failed to cover the run line in eight of their last nine games as road favorites against AL Central opponents.
  • The Royals have trailed after 5 innings in eight of their last nine games as road favorites against AL Central opponents.
  • The Royals have trailed after 3 innings in four of their last five games as road favorites.

Why the Kansas City Royals will win

  • The Royals have won 14 of their last 16 night games against the White Sox following a loss.
  • The White Sox have lost each of their last seven Wednesday home games against AL Central opponents.
  • The Royals have covered the run line in six of their last seven road games against teams that held a losing record.
  • The White Sox have failed to cover the run line in seven of their last eight Wednesday games.
  • The White Sox have trailed after 5 innings in eight of their last nine Wednesday night games.
  • The White Sox have trailed after 3 innings in each of their last six Wednesday games against AL Central opponents that held a losing record.

Total Runs Facts

  • Eight of the White Sox’s last nine games after playing the previous day have gone UNDER the total runs line.
  • Twelve of the Royals’ last 16 night games against AL Central opponents have gone UNDER the total runs line.
  • The ‘Inning 1 OVER 0.5 runs’ market has hit in seven of the White Sox’s last eight night games against American League opponents.
  • The ‘Inning 1 OVER 0.5 runs’ market has hit in five of the Royals’ last six road games.

Chicago White Sox Player Prop Facts

  • Miguel Vargas has hit at least one home run in three of the White Sox’s last seven night games against opponents that held a losing record.
  • Miguel Vargas has recorded at least one hit in each of the White Sox’s last 14 games as underdogs.
  • Munetaka Murakami ranks 3rd in the league in Home Runs (15) this season.

Kansas City Royals Player Prop Facts

  • Salvador Perez has hit a home run in three of the Royals’ last four games as road favorites.
  • Seth Lugo has recorded a win in three of his last four appearances with his team as a road favorite against AL Central opponents .
  • Seth Lugo has recorded six or more strikeouts in four of his last five appearances in night games.
  • Lane Thomas has recorded at least one hit in each of his 14 previous road appearances against AL Central opponents that held a losing record.
  • Bobby Witt Jr. ranks 3rd in the league in Hits (51) this season.

Matchup/League Facts

  • The White Sox rank 30th in the league for doubles this season (46).
  • The White Sox rank 27th in the league for hits this season (311).
  • The Royals rank 27th in the league for walks allowed this season (182).
  • The Royals rank T22nd in the league for runs scored this season (174).

White Sox vs Royals Prediction 

Chicago comes into this matchup on a three game winning streak and they have scored 6+ runs in three of their last four games. The White Sox are 10-9 at home this year, while the Royals are 6-13 on the road. Kansas City has lost three of their last five games and they have allowed 6+ runs in those three losses. The Royals are starting Lugo, who has allowed 13 earned runs in his last three starts, while Schultz has allowed two earned runs or fewer in three of his last four outings, but did allow seven earned runs last time out. I trust Lugo more than Schultz, so I will take the Royals here. 

David Racey's Free Pick: Royals ML

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David Racey

David started writing about sports in 2015, but sports has been his passion for as long as he can remember. David spends most of his free time watching pretty much anything sports related from Baseball to Tennis and everything in between. David likes to analyze statistics and recent results to form an unbiased opinion on whatever game he is breaking down. Follow David on Twitter at @itsyerboi41

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