LA Angels vs St. Louis Cardinals Prediction 7/21/26 MLB Picks Today

The St. Louis Cardinals and the Los Angeles Angels meet Tuesday in MLB action from Angel Stadium. We will look at this from a betting perspective and determine the best bets for this game. Here’s a St. Louis Cardinals vs. Los Angeles Angels prediction.

Starting Pitching Matchup

The St. Louis Cardinals will send out Matthew Liberatore for the start here and Liberatore is 5-6 with a 5.00 ERA and 88 strikeouts this season. Walbert Urena will start for the Angels here and is 5-7 with a 2.88 ERA and 78 strikeouts this season.

St. Louis Cardinals Recap

The St. Louis Cardinals come into this game looking to bounce back from a 3-2 loss at the hands of the Los Angeles Angels last time out to sit at 51-48 this season. After this series, the Cardinals will head home for a series rematch against the Diamondbacks.

Cardinals Lose 3 Games Straight

Going into Monday, Jordan Walker leads the Cardinals with 108 hits, 20 doubles, 22 home runs and 76 RBIs while Alec Burleson has 104 hits with 23 doubles, 15 home runs and 69 RBIs. JJ Wetherholt has 96 hits with 14 home runs and 38 RBIs while Ivan Herrera has 89 hits with 14 doubles, 11 home runs and 41 RBIs. Nolan Gorman has 39 hits with 7 home runs and 26 RBIs this season. Masyn Winn’s added 79 hits with 12 doubles and 42 RBIs and Nathan Church has 56 hits with 8 home runs and 28 RBIs this season.

Los Angeles Angels Recap

The Los Angeles Angels come into this game looking to add on to their victory over the Cardinals on Monday to sit at 40-61 this season. After this series, the Angels will head on the road for a game against the San Francisco Giants.

Angels Win Back-To-Back Games

Nolan Schanuel has 83 hits with 17 doubles, 6 homers and 35 RBIs while Mike Trout’s added 69 hits with 14 doubles, 18 home runs and 39 RBIs this season. Zach Neto’s also added 90 hits with 20 doubles, 19 homers and 46 RBIs and Jo Adell has 91 hits with 15 doubles, 13 home runs and 53 RBIs as well this season. Oswald Peraza has 64 hits with 11 doubles, 7 home runs and 24 RBIs and Jorge Soler has 58 hits with 13 doubles, 11 home runs and 43 RBIs as well this season.

St. Louis Cardinals @ Los Angeles Angels Betting Trends: July 21, 2026

• Probable Starting Pitcher: Walbert Ureña      Record this season: 5-7      ERA: 2.88
• Home Record: 4-2
• Last 5 against Cardinals: –

Why the Los Angeles Angels will win

• The Angels have won each of their last five night games against the Cardinals following a win.
• The Cardinals have lost each of their last four games after playing the previous day.
• The Angels have covered the run line each of their last seven night games against teams that held a winning record.
• The Cardinals have failed to cover the run line in each of their last four games against American League opponents after playing the previous day.
• The Angels have led after 3 innings in seven of their last eight games as favorites against National League opponents.
• The Angels have led after 5 innings in seven of their last eight games as favorites against National League opponents.

• Probable Starting Pitcher: Matthew Liberatore      Record this season: 5-6      ERA: 5.00
• Road Record: 2-4
• Last 5 against Angels: 0-0

Why the St. Louis Cardinals will win

• The Angels have lost six of their last seven games as favorites against National League opponents following a home win.
• The underdogs have won four of the last five games between the Cardinals and Angels.
• The Angels have failed to cover the run line in each of their last seven games as home favorites against NL Central opponents.
• The Cardinals have covered the run line in each of their last seven games as underdogs following a loss.
• The Angels have trailed after 5 innings in eight of their last nine home games against NL Central opponents that held a winning record.
• The Cardinals have won the first inning in three of their last four games against opponents that held a losing record.
• The Cardinals have led after 3 innings in seven of their last eight night games against opponents that held a losing record.

Total Runs Facts

• Each of the Angels’ last seven games have gone UNDER the total runs line.
• Five of the Cardinals’ last six games after playing the previous day have gone UNDER the total runs line.
• There has been no run scored during the first inning in each of the Cardinals’ last eight Tuesday night games.
• There has been at least one run scored in the first inning in eight of the Angels’ last nine night games.

Los Angeles Angels Player Prop Facts

• Mike Trout has hit a home run in three of his last four appearances in night games against teams that held a winning record.
• Walbert Ureña has recorded a win in three of his last four home appearances.
• Walbert Ureña has recorded five or more strikeouts in each of his last four home appearances.
• Nolan Schanuel has recorded at least one hit in each of his last 11 Tuesday appearances.

St. Louis Cardinals Player Prop Facts

• Matthew Liberatore has recorded six or more strikeouts in three of his last four appearances in night games against teams that held a losing record.
• Jordan Walker has recorded at least one hit in each of the Cardinals’ last 11 games.
• Jimmy Crooks has hit a home run in two of his last three appearances with the Cardinals as underdogs.
• Jordan Walker ranks T7th in the league in Hits (109) this season.

Matchup/League Facts

• The Angels rank 30th in the league for strikeouts against this season (958).
• The Angels rank 30th in the league for strikeouts against this season (958).
• The Cardinals rank 28th in the league for doubles this season (133).
• The Cardinals rank 28th in the league for doubles this season (133).

St. Louis Cardinals vs. Los Angeles Angels Prediction

I’m backing the Angels here. Liberatore has been more than hittable on the road this season and I think that the Angels can get to him here. For my money, Walbert Urena is the ace of this Angels’ rotation, even though Jose Soriano had the strong first month of the season, and I think that he holds down the Cardinals here to lead the Angels to the win. Give me the Angels.