Guardians vs Twins Prediction 7/22/26 MLB Picks Today

In this article we will formulate a Guardians vs Twins prediction for this MLB game on Wednesday, July 22nd at Progressive Field in Cleveland, Ohio. Let’s take a look at the prediction for this MLB matchup. 

Cleveland Guardians Betting Preview

The Cleveland Guardians are 54-48 this year after they won the first two games in this series by scores of 13-4 and 5-2. In game two, Cleveland blew a 2-1 lead in the fourth inning, but they scored the last three runs for the win. The Guardians recorded nine hits and they committed two errors in the game, while they were led by Rocchio, who went 2-4 with one RBI. Messick allowed four hits and one earned run over 5.2 innings, while Holderman got the win and Smith picked up the save. Prior to this series, Cleveland lost two out of three against the Pirates, but did sweep the Marlins in three games before that. 

This season, Cleveland has a 3.73 ERA with a 1.26 WHIP and a .238 opponent batting average, while they have scored 410 runs with a .233 batting average and a .313 on base percentage. Chase DeLauter has led the Guardians with 11 home runs and 50 RBIs, while Angel Martinez has added 11 home runs and 33 RBIs. The projected starting pitcher for Cleveland is Slade Cecconi, who is 4-6 with a 4.55 ERA and a 1.41 WHIP over 99.0 innings pitched this year. 

Minnesota Twins Betting Preview

The Minnesota Twins are 49-53 this season after they lost game two by a score of 2-5 on Tuesday. Minnesota led 1-0 in the first inning, but they scored just one run in the final eight innings for the loss. The Twins recorded six hits in the game and they were led by Jeffers, who went 1-4 with one home run and one RBI. Rojas opened the game, while Paredes allowed six hits and two earned runs over 3.0 innings for the loss. Prior to this series, Minnesota lost two out of three against the Cubs, but did win two out of three against the Angels before that. 

This season, Minnesota has a 4.75 ERA with a 1.40 WHIP and a .255 opponent batting average, while they have scored 485 runs with a .247 batting average and a .321 on base percentage. Byron Buxton has led the Twins with 25 home runs and 45 RBIs, while Josh Bell has added 13 home runs and 60 RBIs. The projected starting pitcher for Minnesota is Bailey Ober, who is 7-3 with a 4.32 ERA and a 1.19 WHIP over 77.0 innings pitched this season. 

Why the Cleveland Guardians will win

• The Guardians have won eight of their last nine games against AL Central opponents following a win.
• The Twins have lost seven of their last eight night games against the Guardians following a loss.
• The Guardians have covered the run line in seven of their last eight games after playing the previous day.
• The Twins have failed to cover the run line in each of their last four games.
• The Twins have lost the first inning in four of their last five games.
• The Guardians have led after 3 innings in each of their last 10 home games against opponents that held a losing record.
• The Guardians have led after 5 innings in eight of their last 10 home games against opponents that held a losing record.

Why the Minnesota Twins will win

• The underdogs have won three of the Twins’ last four games at Progressive Field.
• The Guardians have lost three of their last four games as home favorites following a win.
• The Guardians have failed to cover the run line in 12 of their last 13 night games at Progressive Field following a home win.
• The underdogs have covered the run line in 14 of the Twins’ last 16 games at Progressive Field.
• The Twins have won the first inning in four of their last five games as road underdogs against American League opponents.
• The Twins have led after 5 innings in six of their last eight games as road underdogs against American League opponents.

Total Runs Facts

• Each of the Twins’ last four games as underdogs against American League opponents have gone UNDER the total runs line.
• Five of the Guardians’ last six games as favorites against AL Central opponents have gone UNDER the total runs line.
• There has been at least one run scored in the first inning in each of the Twins’ last 10 road games.
• There has been at least one run scored in the first inning in each of the last five night games between the Twins and Guardians at Progressive Field.

Cleveland Guardians Player Prop Facts

• Slade Cecconi has recorded four or more strikeouts in five of his six previous appearances against AL Central opponents that held a losing record.
• Steven Kwan has recorded at least one hit in each of the Guardians’ last 13 games as home favorites.
• Slade Cecconi has recorded a win in three of his last four appearances against AL Central opponents that held a losing record.
• Rhys Hoskins has hit at least one home run in three of his last four appearances against the Twins.

Minnesota Twins Player Prop Facts

• Ryan Jeffers has hit a home run in each of his last two appearances in night games.
• Ryan Jeffers has recorded at least one hit in each of his last 10 appearances with the Twins as road underdogs against AL Central opponents.
• Bailey Ober has recorded a win in five of his last six appearances in night games.

Guardians vs Twins Prediction 

Minnesota comes into this matchup on a four game losing streak and they have allowed 34 runs during that span. The Twins are 23-28 on the road this year, while the Guardians are 27-24 at home. Cleveland has won three of their last five games and they are tied for first in the AL Central. The Guardians are starting Cecconi, who has allowed eight earned runs in his last 8.2 innings, while Ober has allowed 2, 1, 7, 4, and 3 earned runs in his last five starts. Take the over in this matchup.