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Yankees vs Pirates Prediction 7/22/26 MLB Picks Today

Pittsburgh Pirates (52-49) vs. NY Yankees (56-44)
July 22, 2026 1:05 pm EDT
The Line: NY Yankees -167 / Pittsburgh Pirates 138; Over/Under: 9
(Get latest betting odds)

The Pittsburgh Pirates and New York Yankees meet Wednesday in an MLB doubleheader at Comerica Park. Here’s a Yankees vs Pirates Prediction. This article will include a Yankees vs Pirates Pick.

Pittsburgh Pirates Betting Preview

The Pittsburgh Pirates are 52-49 on the year and play the Cubs and Diamondbacks next. The Pittsburgh Pirates are batting .263 on the season and have a .341 OBP and a .427 slugging percentage. The Pittsburgh Pirates’ pitching staff has a 4.30 ERA and a 1.32 WHIP. Nick Gonzales leads the Pittsburgh Pirates with 110 hits and 45 RBIs, while Bryan Reynolds and Brandon Lowe have combined for 193 hits and 124 RBIs.

Mitch Keller and Bubba Chandler get the ball for the Pittsburgh Pirates.

New York Yankees Betting Preview

The New York Yankees are 56-44 on the year and play the Phillies and White Sox next. The New York Yankees are batting .237 on the season and have a .316 OBP and a .423 slugging percentage. The New York Yankees’ pitching staff has a 3.42 ERA and a 1.19 WHIP. Ben Rice leads the New York Yankees with 99 hits and 68 RBI, while Cody Bellinger and Jazz Chisholm Jr. have combined for 168 hits and 95 RBI.

Gerrit Cole and Max Fried get the ball for the New York Yankees.

Why the New York Yankees will win

  • The Yankees have won each of their last 11 Wednesday games against teams that held a winning record.
  • The Pirates have lost seven of their last eight road games against AL East opponents.
  • The Yankees have covered the run line in seven of their last eight games.
  • The Pirates have failed to cover the run line in four of their last five games on the first leg of a doubleheader.
  • The Yankees have won the first inning in each of their last three games against NL Central opponents that held a winning record.
  • The Yankees have led after 3 innings in five of their last six games against NL Central opponents.
  • The Yankees have led after 5 innings in four of their last five games.

Why the Pittsburgh Pirates will win

  • The Pirates have won each of their last four games as underdogs against American League opponents following a road loss.
  • The Yankees have lost six of their last eight games as home favorites.
  • The Pirates have covered the run line in each of their last seven games as underdogs against AL East opponents following a loss.
  • The Yankees have failed to cover the run line in six of their last seven games on the first leg of a doubleheader against National League opponents.
  • The Yankees have lost the first inning in five of their last six day games.
  • The Yankees have trailed after 3 innings in seven of their last eight day games.
  • The Yankees have trailed after 5 innings in each of their last six home day games.

Total Runs Facts

  • Each of the last six games between the Pirates and Yankees has gone OVER the total runs line.
  • Five of the Pirates’ last six games as road underdogs have gone OVER the total runs line.
  • There has been at least one run scored in the first inning in each of the Pirates’ last six games against AL East opponents.
  • There has been at least one run scored in the first inning in each of the Yankees’ last four games as home favorites.

New York Yankees Player Prop Facts

  • Jazz Chisholm has hit at least one home run in three of his last four home appearances against the Pirates.
  • Gerrit Cole has recorded eight or more strikeouts in each of his last 10 Wednesday appearances in day games.
  • Ben Rice has recorded at least one hit in each of the Yankees’ last 14 games against opponents that held a winning record.
  • Ben Rice ranks 2nd amongst qualified players for Slugging Percentage (.594) this season.

Pittsburgh Pirates Player Prop Facts

  • Esmerlyn Valdez has hit a home run in five of the Pirates’ last six games as underdogs.
  • Mitch Keller has recorded seven or more strikeouts in each of his last seven road appearances against AL opponents that held a winning record.
  • Nick Gonzales has recorded at least one hit in each of the Pirates’ last 10 road games.
  • Mitch Keller has recorded a win in each of his last three appearances against AL East opponents.
  • Nick Gonzales ranks 5th amongst qualified players for Batting Average (.309) this season.

Matchup/League Facts

  • The Yankees rank 1st in the league for ERA this season (3.42).
  • The Yankees rank 1st in the league for ERA this season (3.42).
  • The Pirates rank 1st in the league for hits this season (923).
  • The Pirates rank 1st in the league for hits this season (923).

Yankees vs Pirates Prediction

Game 1 Prediction: Keller has allowed 3 or more earned runs in 4 straight starts, and he has a 5.14 ERA and 1.33 WHIP on the season. Cole is starting to find his form, and he’s allowed 16 hits and 7 runs in his last 17.1 innings. During those frames, he has 21 strikeouts and 2 walks. Clear edge on the mound in the first game of a doubleheader, I have to side with the Yankees behind their ace.

Game 2 Prediction: Chandler isn’t a pitcher I’m excited to back, especially lately where he’s allowed 18 hits and 11 runs in his last 15 innings. The Yankees should be excited to see the 23-year-old. However, Fried hasn’t pitched in two months due to an elbow injury, so who knows what to expect from him. Fried was a mess before he went on the IL, allowing 17 hits and 11 runs in his last 14.1 innings. Expect some offense. Give me the over in Game 2.

Randy Chambers's Free Pick: Game 1: Yankees / Game 2: Over

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Randy Chambers

Randy has covered sports betting since 2014 and writes about everything from NFL to WNBA. Follow Randy Chambers on Twitter.

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