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Cardinals vs Reds Prediction 7/24/26 MLB Picks Today

Cincinnati Reds (47-54) vs. St. Louis Cardinals (52-50)
July 24, 2026 8:15 pm EDT
The Line: St. Louis Cardinals -168 / Cincinnati Reds 139; Over/Under: 8.5
(Get latest betting odds)

The Cincinnati Reds and St. Louis Cardinals meet Friday in MLB action at Busch Stadium. Here’s a Cardinals vs Reds Prediction. This article will include a Cardinals vs Reds Pick.

Cincinnati Reds Betting Preview

The Cincinnati Reds are 47-54 on the year and play the Guardians and Pirates next. The Cincinnati Reds are batting .230 on the season, have a .309 OBP, and have a .400 slugging percentage. The Cincinnati Reds’ pitching staff has a 4.56 ERA and a 1.43 WHIP. Sal Stewart leads the Cincinnati Reds with 96 hits and 74 RBI, while Elly De La Cruz and Spencer Steer have combined for 171 hits and 86 RBI.

Rhett Lowder gets the ball for the Cincinnati Reds, and he is 3-7 with a 5.75 ERA and 61 strikeouts this season. Lowder is 1-0 with a 0.00 ERA and 7 strikeouts in his career against the St. Louis Cardinals.

St. Louis Cardinals Betting Preview

The St. Louis Cardinals are 52-50 on the year and play the Cubs and Blue Jays next. The St. Louis Cardinals are batting .241 on the season, with a .317 OBP and a .384 slugging percentage. The St. Louis Cardinals’ pitching staff has a 4.18 ERA and a 1.34 WHIP. Jordan Walker leads the St. Louis Cardinals with 112 hits and 77 RBI, while Alec Burleson and JJ Wetherholt have combined for 209 hits and 109 RBI.

Dustin May gets the ball for the St. Louis Cardinals, and he is 5-7 with a 4.78 ERA and 95 strikeouts this season. This will be May’s first career game against the Cincinnati Reds.

Why the St. Louis Cardinals will win

  • The Reds have lost each of their last six night games following a win.
  • The Cardinals have won seven of their last eight night games against the Reds at Busch Stadium following a home loss.
  • The Cardinals have covered the run line in seven of their last eight games against National League opponents following a loss.
  • The Reds have failed to cover the run line in four of their last five road games against NL Central opponents.
  • The Cardinals have won the first inning in each of their last three home games.
  • The Cardinals have led after 3 innings in each of their last three games against National League opponents that held a losing record.
  • The Cardinals have led after 5 innings in each of their last three night games against National League opponents that held a losing record.

Why the Cincinnati Reds will win

  • The Cardinals have lost four of their last five games as favorites.
  • The Reds have won four of their last five games as road underdogs.
  • The Cardinals have failed to cover the run line in 12 of their last 13 games as favorites after playing the previous day.
  • The Reds have covered the run line in seven of their last eight games as underdogs against the Cardinals following a win.
  • The Cardinals have trailed after 5 innings in four of their last five home games.
  • The Reds have won the first inning in four of their last five road games against opponents that held a winning record.
  • The Reds have led after 3 innings in three of their last four games against National League opponents.

Total Runs Facts

  • Nine of the Reds’ last 10 night games as underdogs have gone UNDER the total runs line.
  • Each of the Cardinals’ last four night games after playing the previous day have gone UNDER the total runs line.
  • There has been at least one run scored in the first inning in each of the Reds’ last seven road games against National League opponents.
  • There has been no run scored during the first inning in four of the last five games between the Reds and Cardinals.

St. Louis Cardinals Player Prop Facts

  • Alec Burleson has hit a home run in each of the Cardinals’ last three games against NL opponents that held a losing record.
  • Dustin May has recorded seven or more strikeouts in four of his last five home appearances.
  • Jordan Walker has recorded at least one hit in each of the Cardinals’ last 11 games against NL opponents.
  • Jordan Walker ranks 8th in the league in Hits (112) this season.

Cincinnati Reds Player Prop Facts

  • Eugenio Suarez has hit a home run in each of the Reds’ last three games against opponents that held a winning record.
  • Rhett Lowder has recorded four or more strikeouts in five of his last six appearances with the Reds as underdogs.
  • Tyler Stephenson has recorded at least one hit in each of his last 15 road appearances against NL opponents.
  • Elly De La Cruz is one of only seven players to record 10+ Home Runs and 4+ Triples this season.

Matchup/League Facts

  • The Cardinals rank T2nd in the league for home runs allowed this season (101).
  • The Cardinals rank T2nd in the league for home runs allowed this season (101).
  • The Reds rank 30th in the league for hits this season (777).
  • The Reds rank 30th in the league for hits this season (777).

Cardinals vs Reds Prediction

The Reds are hot offensively, and that should continue here with May on the mound. May has a 4.78 ERA and 1.32 WHIP on the season, and he’s allowed 19 hits and 12 runs in his last 14.1 innings. Lowder hasn’t been any better with a 5.75 ERA and 1.64 WHIP, and he’s allowed 16 hits and 9 runs in his last 9.1 innings. In 37 innings on the road, Lowder has an 8.27 ERA and a .321 allowed batting average. Two pitchers in poor form. I expect runs. I’ll take the over.

Randy Chambers's Free Pick: Over 8.5

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Randy Chambers

Randy has covered sports betting since 2014 and writes about everything from NFL to WNBA. Follow Randy Chambers on Twitter.

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