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Cardinals vs Reds Prediction 7/25/26 MLB Picks Today

Cincinnati Reds (48-54) vs. St. Louis Cardinals (52-51)
July 25, 2026 7:15 pm EDT
The Line: St. Louis Cardinals -123 / Cincinnati Reds 102; Over/Under: 8.5
(Get latest betting odds)

The Cincinnati Reds and St. Louis Cardinals meet Saturday in MLB action at Busch Stadium. Here’s a Cardinals vs Reds Prediction. This article will include a Cardinals vs Reds Pick.

Cincinnati Reds Betting Preview

The Cincinnati Reds are 48-54 on the year and play the Guardians and Pirates next. The Cincinnati Reds are batting .230 on the season, have a .309 OBP, and have a .400 slugging percentage. The Cincinnati Reds’ pitching staff has a 4.53 ERA and a 1.42 WHIP. Sal Stewart leads the Cincinnati Reds with 98 hits and 75 RBI, while Elly De La Cruz and Spencer Steer have combined for 172 hits and 86 RBI.


Hunter Greene gets the ball for the Cincinnati Reds, and he is 2-1 with a 6.06 ERA and 26 strikeouts this season. Greene is 2-4 with a 3.23 ERA and 65 strikeouts in his career against the St. Louis Cardinals.

St. Louis Cardinals Betting Preview

The St. Louis Cardinals are 52-51 on the year and play the Cubs and Blue Jays next. The St. Louis Cardinals are batting .240 on the season, with a .316 OBP and a .382 slugging percentage. The St. Louis Cardinals’ pitching staff has a 4.17 ERA and a 1.34 WHIP. Jordan Walker leads the St. Louis Cardinals with 112 hits and 77 RBI, while Alec Burleson and JJ Wetherholt have combined for 209 hits and 109 RBI.

Andre Pallante gets the ball for the St. Louis Cardinals, and he is 10-6 with a 4.02 ERA and 75 strikeouts this season. Pallante is 7-4 with a 2.41 ERA and 52 strikeouts in his career against the Cincinnati Reds.

Why the St. Louis Cardinals will win

  • The Reds have lost each of their last six Saturday night games at Busch Stadium.
  • The home team has won four of the last five games between the Reds and Cardinals.
  • The Cardinals have covered the run line in four of their last five games against National League opponents that held a losing record.
  • The Reds have failed to cover the run line in three of their last four games against the Cardinals following a win.
  • The Cardinals have won the first inning in three of their last four home games.
  • The Cardinals have led after 3 innings in three of their last four games against National League opponents that held a losing record.
  • The Cardinals have led after 5 innings in each of their last four night games against National League opponents that held a losing record.

Why the Cincinnati Reds will win

  • The Cardinals have lost each of their last four games as favorites.
  • The Reds have won five of their last six games as road underdogs.
  • The Cardinals have failed to cover the run line in 13 of their last 14 games as favorites after playing the previous day.
  • The Reds have covered the run line in eight of their last nine games as underdogs against the Cardinals following a win.
  • The Reds have led after 5 innings in each of their last six Saturday night games as road underdogs.

Total Runs Facts

  • Each of the Reds’ last six night games against NL Central opponents have gone UNDER the total runs line.
  • Each of the Cardinals’ last five night games after playing the previous day have gone UNDER the total runs line.
  • There has been at least one run scored in the first inning in seven of the Reds’ last eight road games against National League opponents.
  • There has been no run scored during the first inning in each of the Cardinals’ last four games as favorites against NL Central opponents.

St. Louis Cardinals Player Prop Facts

  • Alec Burleson has hit a home run in three of the Cardinals’ last four games against NL opponents that held a losing record.
  • Andre Pallante has recorded five or more strikeouts in each of his last five appearances against opponents that held a losing record.
  • Jordan Walker has recorded at least one hit in each of the Cardinals’ last eight Saturday games as favorites.
  • Andre Pallante has recorded a win in three of his last four appearances with the Cardinals as favorites.
  • Jordan Walker ranks T8th in the league in Hits (112) this season.

Cincinnati Reds Player Prop Facts

  • Eugenio Suarez has hit a home run in each of the Reds’ last four games against opponents that held a winning record.
  • Hunter Greene has recorded seven or more strikeouts in each of his last four appearances against NL Central opponents.
  • Tyler Stephenson has recorded at least one hit in each of his last 16 road appearances against NL opponents.
  • Hunter Greene has recorded a win in three of his last four appearances against opponents that held a winning record.
  • Elly De La Cruz is one of only seven players to record 10+ Home Runs and 4+ Triples this season.

Matchup/League Facts

  • The Cardinals rank T2nd in the league for home runs allowed this season (102).
  • The Cardinals rank T2nd in the league for home runs allowed this season (102).
  • The Reds rank 29th in the league for hits this season (788).
  • The Reds rank 29th in the league for hits this season (788).

Cardinals vs Reds Prediction

When Greene is right, he’s a talented arm, but he has just 16.1 innings under his belt and has a 6.06 ERA. The Cardinals have also had success against Greene, as current hitters are batting .268 with a .375 on-base percentage in 41 at-bats. On the other side, Pallante has allowed 18 hits and 9 runs in his last 16 innings. In 61.1 frames at home, Pallante has a 4.99 ERA and a .293 allowed batting average. Two shaky at best pitchers. I expect offense. Give me the over.

Randy Chambers's Free Pick: Cincinnati Reds 102

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Randy Chambers

Randy has covered sports betting since 2014 and writes about everything from NFL to WNBA. Follow Randy Chambers on Twitter.

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