Cubs vs White Sox Prediction 8/18/26 MLB Picks Today
Chicago White Sox (65-59) vs. Chicago Cubs (73-53)
August 18, 2026 8:05 pm EDT
The Line: Chicago Cubs -161 / Chicago White Sox 150; Over/Under: 8.5
(Get latest betting odds)
The Chicago White Sox and Chicago Cubs meet Tuesday in MLB action at Wrigley Field. Here’s a Cubs vs White Sox Prediction. This article will include a Cubs vs White Sox Pick.
Chicago White Sox Betting Preview
The Chicago White Sox are 65-59 on the year and play the Braves and Mets next. The Chicago White Sox are batting .239 on the season, have a .318 OBP, and have a .411 slugging percentage. The Chicago White Sox pitching staff has a 4.11 ERA and a 1.30 WHIP. Chase Meidroth leads the Chicago White Sox with 121 hits and 49 RBI, while Sam Antonacci and Miguel Vargas have combined for 207 hits and 108 RBI.
Bryan Hudson gets the ball for the Chicago White Sox, and he is 3-4 with a 3.14 ERA and 50 strikeouts this season. Hudson is 2-1 with a 4.66 ERA and 9 strikeouts in his career against the Chicago Cubs.
Chicago Cubs Betting Preview
The Chicago Cubs are 73-53 on the year and play the Mariners and Diamondbacks next. The Chicago Cubs are batting .249 on the season and have a .338 OBP and a .419 slugging percentage. The Chicago Cubs’ pitching staff has a 4.16 ERA and a 1.26 WHIP. Pete Crow-Armstrong leads the Chicago Cubs with 135 hits and 78 RBI, while Alex Bregman and Nico Hoerner have combined for 254 hits and 119 RBI.
Kevin Gausman gets the ball for the Chicago Cubs, and he is 6-11 with a 4.53 ERA and 138 strikeouts this season. Gausman is 2-0 with a 2.30 ERA and 31 strikeouts in his career against the Chicago White Sox.
Why the Chicago Cubs will win
- The White Sox have lost each of their last 10 road games against NL Central opponents that held a winning record.
- The Cubs have won each of their last seven home games against the White Sox.
- The White Sox have failed to cover the run line each of their last seven road games against NL Central opponents that held a winning record.
- The Cubs have covered the run line each of their last six night games against teams that held a winning record.
- The White Sox have trailed after 3 innings in each of their last four games at Wrigley Field.
- The White Sox have trailed after 5 innings in six of their last seven games as road underdogs against National League opponents.
- The Cubs have won the first inning in each of their last four games as favorites against the White Sox.
Why the Chicago White Sox will win
- The White Sox have won each of their last four games as road underdogs following an extra-innings loss.
- The Cubs have lost five of their last six games as home favorites against American League opponents following a win.
- The White Sox have covered the run line in each of their last six road games following an extra-innings loss.
- The Cubs have failed to cover the run line in 10 of their last 11 night games against AL Central opponents following a home win.
- The White Sox have led after 5 innings in four of their last five night games against National League opponents.
- The Cubs have trailed after 3 innings in three of their last four night games.
Total Runs Facts
- Seven of the last eight games between the White Sox and Cubs have gone OVER the total runs line.
- Seven of the White Sox’s last eight games against NL Central opponents have gone OVER the total runs line.
- There has been at least one run scored in the first inning in each of the Cubs’ last 13 games against AL Central opponents.
- There has been at least one run scored in the first inning in each of the White Sox’s last seven games as underdogs against NL Central opponents.
Chicago Cubs Player Prop Facts
- Seiya Suzuki has hit a home run in three of the Cubs’ last four home games against AL Central opponents.
- Nico Hoerner has recorded at least one hit in each of the Cubs’ last 12 games against the White Sox.
- Kevin Gausman has recorded a win in three of his last four appearances against AL Central opponents.
- Pete Crow-Armstrong ranks 4th amongst qualified players for Slugging Percentage (.550) this season.
Chicago White Sox Player Prop Facts
- Munetaka Murakami has hit a home run in three of the White Sox’s last four road games against NL Central opponents.
- Miguel Vargas has recorded at least one hit in each of the White Sox’s last 13 road games against NL opponents.
- Munetaka Murakami ranks 7th amongst qualified players for Slugging Percentage (.539) this season.
Matchup/League Facts
- The Cubs rank 1st in the league for on-base percentage this season (.338).
- The Cubs rank 1st in the league for walks this season (536).
- The White Sox rank T4th in the league for home runs this season (166).
- The White Sox rank T25th in the league for strikeouts against this season (1135).
Cubs vs White Sox Prediction
The Cubs are going to be favored as they’re the better team at home, and Gausman is a veteran who was brought to Chicago to bolster this rotation. However, Gausman has been hittable with a 4.53 ERA and 1.27 WHIP. The White Sox have also been a money-maker for us this season, as oddsmakers haven’t believed in them, and yet here they are chasing down a division title. Hudson has just 51.2 innings, but he’s been solid with a 3.14 ERA and 1.28 WHIP. Like I have all season, I’m going to grab the plus money with the White Sox.