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Cardinals vs Orioles Prediction 8/26/26 MLB Picks Today

Baltimore Orioles (64-68) vs. St. Louis Cardinals (66-67)
August 26, 2026 7:45 pm EDT
The Line: St. Louis Cardinals -110 / Baltimore Orioles -110; Over/Under: 8
(Get latest betting odds)

The Baltimore Orioles and St. Louis Cardinals meet Wednesday in MLB action at Busch Stadium. Here’s a Cardinals vs Orioles Prediction. This article will include a Cardinals vs Orioles Pick.

Baltimore Orioles Betting Preview

The Baltimore Orioles are 64-68 on the year and play the Rockies and Athletics next. The Baltimore Orioles are batting .236 on the season, with a .313 OBP and a .402 slugging percentage. The Baltimore Orioles pitching staff has a 4.17 ERA and a 1.34 WHIP. Pete Alonso leads the Baltimore Orioles with 137 hits and 89 RBI, while Leody Taveras and Gunnar Henderson have combined for 197 hits and 97 RBI.

Kyle Bradish gets the ball for the Baltimore Orioles, and he is 7-12 with a 3.70 ERA and 129 strikeouts this season. Bradish is 1-0 with a 2.25 ERA and 17 strikeouts in his career against the St. Louis Cardinals.

St. Louis Cardinals Betting Preview

The St. Louis Cardinals are 66-67 on the year and play the Pirates and Dodgers next. The St. Louis Cardinals are batting .241 on the season, with a .316 OBP and a .381 slugging percentage. The St. Louis Cardinals’ pitching staff has a 4.21 ERA and a 1.34 WHIP. Alec Burleson leads the St. Louis Cardinals with 146 hits and 96 RBI, while Jordan Walker and JJ Wetherholt have combined for 264 hits and 144 RBI.

Michael McGreevy gets the ball for the St. Louis Cardinals, and he is 5-9 with a 3.54 ERA and 95 strikeouts this season. This will be McGreevy’s first career game against the Baltimore Orioles.

Why the St. Louis Cardinals will win

  • The Cardinals have won each of their last seven Wednesday games against AL opponents that held a losing record.
  • The Orioles have lost each of their last four night games against the Cardinals following a win.
  • The Cardinals have covered the run line each of their last seven Wednesday games against AL opponents that held a losing record.
  • The Orioles have failed to cover the run line in each of their last four night games against the Cardinals following a win.
  • The Orioles have trailed after 3 innings in four of their last five night games.
  • The Cardinals have led after 5 innings in six of their last seven games against opponents that held a losing record.

Why the Baltimore Orioles will win

  • The Cardinals have lost each of their last eight games against AL East opponents following a home loss.
  • The Orioles have won each of their last four night games against NL Central opponents that held a losing record.
  • The Cardinals have failed to cover the run line each of their last six night games against AL opponents that held a losing record.
  • The Orioles have covered the run line in seven of their last eight road games against NL opponents.
  • The Orioles have led after 3 innings in four of their last five games against the Cardinals.
  • The Orioles have led after 5 innings in each of their last four road games.

Total Runs Facts

  • Each of the Cardinals’ last six games has gone OVER the total runs line.
  • Five of the Orioles’ last six road games have gone OVER the total runs line.
  • There has been at least one run scored in the first inning in each of Michael McGreevy’s last nine appearances as a starter.
  • There has been no run scored during the first inning in each of the Orioles’ last eight Wednesday games against NL Central opponents.

St. Louis Cardinals Player Prop Facts

  • Jordan Walker has hit a home run in two of the Cardinals’ last three home games against AL East opponents.
  • Michael McGreevy has recorded five or more strikeouts in three of his last four appearances in night games.
  • Alec Burleson has recorded at least one hit in each of the Cardinals’ last 11 games.
  • Alec Burleson ranks T6th in the league in Hits (145) this season.

Baltimore Orioles Player Prop Facts

  • Christian Encarnacion-Strand has hit a home run in three of the Orioles’ last four road games.
  • Kyle Bradish has recorded five or more strikeouts in each of his nine previous appearances against NL Central opponents.
  • Samuel Basallo has recorded at least one hit in each of the Orioles’ last seven night games against NL opponents that held a losing record.
  • Pete Alonso ranks T8th in the league in Home Runs (30) this season.

Matchup/League Facts

  • The Cardinals rank 27th in the league for doubles this season (187).
  • The Cardinals rank T4th in the league for strikeouts against this season (1030).
  • The Orioles rank 3rd in the league for walks this season (491).
  • The Orioles rank 27th in the league for hits this season (1020).

Cardinals vs Orioles Prediction

The Orioles are in a better position in terms of the playoffs, and Bradish has been sharp, but he hasn’t gotten much run support lately. The Orioles have scored 1 or fewer runs in 3 of Bradish’s last 4 starts. In the month of August, McGreevy has allowed 20 hits and 8 earned runs in 21.1 innings, and the Cardinals are 4-0 in those games. Pick em price, I’ll take a shot with the Cards at home.

Randy Chambers's Free Pick: St. Louis Cardinals -110

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Randy Chambers

Randy has covered sports betting since 2014 and writes about everything from NFL to WNBA. Follow Randy Chambers on Twitter.

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