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Padres vs Yankees Prediction 9/4/26 MLB Picks Today

NY Yankees (80-60) vs. San Diego Padres (73-67)
September 4, 2026 9:40 pm EDT
The Line: San Diego Padres 112 / NY Yankees -135; Over/Under: 7.5
(Get latest betting odds)

The New York Yankees and San Diego Padres meet Friday in MLB action at Petco Park. Here’s a Padres vs Yankees Prediction. This article will include a Padres vs Yankees Pick.

New York Yankees Betting Preview

The New York Yankees are 80-60 this year and play the Rockies and Mets next. The New York Yankees are batting .234 on the season, with a .311 OBP and a .409 slugging percentage. The New York Yankees’ pitching staff has a 3.24 ERA and a 1.17 WHIP. Ben Rice leads the New York Yankees with 127 hits and 87 RBI, while Cody Bellinger and Jazz Chisholm Jr. have combined for 216 hits and 115 RBI.

Max Fried gets the ball for the New York Yankees, and he is 4-4 with a 2.80 ERA and 83 strikeouts this season. Fried is 3-1 with a 2.11 ERA and 31 strikeouts in his career against the San Diego Padres.

San Diego Padres Betting Preview

The San Diego Padres are 73-67 on the year and play the Nationals and Giants next. The San Diego Padres are batting .237 on the season, have a .315 OBP, and have a .387 slugging percentage. The San Diego Padres’ pitching staff has a 3.94 ERA and a 1.29 WHIP. Fernando Tatis Jr. leads the San Diego Padres with 154 hits and 70 RBI, while Jackson Merrill and Manny Machado have combined for 239 hits and 145 RBI.

Walker Buehler gets the ball for the San Diego Padres, and he is 8-6 with a 4.66 ERA and 111 strikeouts this season. Buehler is 0-1 with a 14.54 ERA and 4 strikeouts in his career against the New York Yankees.

Why the San Diego Padres will win

  • The Padres have won each of their last seven night games following a road loss.
  • The Yankees have lost four of their last five games as favorites following a win.
  • The Padres have covered the run line in each of their last eight games as underdogs following a loss.
  • The Yankees have failed to cover the run line in seven of their last eight night games against NL West opponents following a win.
  • The Yankees have lost the first inning in three of their last four night games against NL opponents that held a winning record.
  • The Padres have led after 5 innings in seven of their last nine home games against AL opponents that held a winning record.
  • The Padres have led after 3 innings in each of their last four games as home underdogs against AL opponents.

Why the New York Yankees will win

  • The Padres have lost each of their last eight Friday home games against AL East opponents.
  • The Yankees have won seven of their last eight night games after going to extra innings.
  • The Padres have failed to cover the run line in each of their last nine night games against AL East opponents.
  • The Yankees have covered the run line in each of their last seven games after going to extra innings.
  • The Yankees have led after 5 innings in each of their last four night games against NL West opponents.
  • The Padres have trailed after 3 innings in seven of their last eight night games against AL opponents.

Total Runs Facts

  • Ten of the Yankees’ last 11 road games after going to extra innings have gone UNDER the total runs line.
  • Seven of the Padres’ last eight games as underdogs against AL East opponents have gone OVER the total runs line.
  • There has been no run scored during the first inning in eight of the Padres’ last nine games as home underdogs.
  • There has been no run scored during the first inning in each of the Yankees’ last five games against NL opponents.

San Diego Padres Player Prop Facts

  • Jackson Merrill has hit a home run in four of the Padres’ last five home games against AL opponents.
  • Walker Buehler has recorded five or more strikeouts in four of his last five appearances with the Padres as underdogs against AL opponents.
  • Jackson Merrill has recorded at least one hit in each of the Padres’ last eight home games against opponents that held a winning record.
  • Walker Buehler has recorded a win in three of his last four appearances in night games against teams that held a winning record.
  • Fernando Tatis Jr. ranks 6th in the league in Steals (31) this season.

New York Yankees Player Prop Facts

  • Spencer Jones has hit a home run in three of the Yankees’ last four road games.
  • Max Fried has recorded five or more strikeouts in each of his last four road appearances against NL opponents that held a winning record.
  • Heliot Ramos has recorded at least one hit in each of his last 14 appearances with his team as a road favorite against NL opponents.
  • Max Fried has recorded a win in four of his last five appearances with the Yankees as road favorites against NL opponents.
  • Jazz Chisholm ranks 2nd in the league in Steals (40) this season.

Matchup/League Facts

  • The Padres rank 3rd in the league for steals this season (138).
  • The Padres rank 26th in the league for hits this season (1096).
  • The Yankees rank 1st in the league for ERA this season (3.24).
  • The Yankees rank 1st in the league for runs allowed this season (521).

Padres vs Yankees Prediction

Buehler is coming off a solid month, but he still has a 4.66 ERA and 1.36 WHIP on the season. Fried has been far more consistent with a 2.80 ERA and 1.00 WHIP, and he’s allowed 13 hits and 3 runs in his last 20.1 innings. Through 52.2 innings on the road, Fried has a 2.56 ERA and a .198 allowed batting average. The Yankees have the more trustworthy arm and are the more consistent team overall. The price isn’t crazy. Give me the Yankees.

Randy Chambers's Free Pick: NY Yankees -135

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Randy Chambers

Randy has covered sports betting since 2014 and writes about everything from NFL to WNBA. Follow Randy Chambers on Twitter.

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