Orioles vs Guardians Prediction 9/7/26 MLB Picks Today
Cleveland Guardians (73-71) vs. Baltimore Orioles (69-75)
September 7, 2026 1:35 pm EDT
The Line: Baltimore Orioles -126 / Cleveland Guardians 104; Over/Under: 8.5
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In this article we will formulate an Orioles vs Guardians prediction for this MLB game on Monday, September 7th at Camden Yards in Baltimore, Maryland. Let’s take a look at the prediction for this MLB matchup.
Baltimore Orioles Betting Preview
The Baltimore Orioles are 69-75 this season after they lost all four against the Red Sox by scores of 5-6, 0-1, 0-5, and 1-3. In game four, Baltimore led 1-0 in the first inning, but they went scoreless over the last eight innings for the loss. The Orioles recorded five hits and they committed one error in the game, while they were led by Encarnacion-Strand, who went 1-4 with one RBI. Bradish allowed two hits and zero earned runs over 4.0 innings for the loss, while Nunez threw two innings in relief. Prior to that series, Baltimore lost two out of three against the Rockies, but did sweep the Athletics before that.
This season, Baltimore has a 4.13 ERA with a 1.34 WHIP and a .253 opponent batting average, while they have scored 641 runs with a .234 batting average and a .315 on base percentage. Pete Alonso has led the Orioles with 33 home runs and 94 RBIs, while Gunnar Henderson has added 22 home runs and 57 RBIs. The projected starting pitcher for Baltimore is Trevor Rogers, who is 9-9 with a 4.30 ERA and a 1.23 WHIP over 144.1 innings pitched this season.
Cleveland Guardians Betting Preview
The Cleveland Guardians are 73-71 this year after they won three out of four against the Tigers by scores of 7-6, 4-3, 0-6, and 3-2. In game four, Cleveland trailed 2-0 in the first inning, but they tied the game in the fifth and won in the 10th. The Guardians recorded seven hits in the game and they were led by Rocchio, who went 1-3 with one home run and one RBI. Williams allowed four hits and two earned runs over 6.0 innings, while Smith picked up the win. Prior to that series, Cleveland lost two out of three against the Blue Jays and two out of three against the Royals.
This season, Cleveland has a 3.75 ERA with a 1.26 WHIP and a .237 opponent batting average, while they have scored 580 runs with a .236 batting average and a .313 on base percentage. Chase DeLauter has led the Guardians with 13 home runs and 60 RBIs, while Angel Martinez has added 14 home runs and 50 RBIs. The projected starting pitcher for Cleveland is Joey Cantillo, who is 9-8 with a 3.81 ERA and a 1.48 WHIP over 141.2 innings pitched this year.
Why the Baltimore Orioles will win
- The Guardians have lost each of their last six day games against AL East opponents.
- The Orioles have won seven of their last eight day games against AL Central opponents following a loss.
- The Guardians have failed to cover the run line in each of their last six games.
- The Orioles have covered the run line in each of their last seven Monday day games.
- The Guardians have trailed after 3 innings in each of their last four games.
- The Guardians have trailed after 5 innings in each of their last four games as underdogs against AL East opponents.
- The Guardians have lost the first inning in three of their last four games.
Why the Cleveland Guardians will win
- The Orioles have lost each of their last six games.
- The Guardians have won each of their last six road games.
- The underdogs have covered the run line in each of the Guardians’ last five games.
- The Orioles have failed to cover the run line in nine of their last 11 home games against AL Central opponents that held a winning record.
- The Guardians have led after 3 innings in five of their last six day games against AL East opponents that held a losing record.
- The Orioles have trailed after 5 innings in nine of their last 11 day games against AL Central opponents.
Total Runs Facts
- Nine of the Guardians’ last 10 road games following an extra innings win have gone UNDER the total runs line.
- Six of the Orioles’ last seven games have gone UNDER the total runs line.
- There has been no run scored during the first inning in each of the Guardians’ last six road games against AL East opponents.
- There has been no run scored during the first inning in nine of Trevor Rogers’ last 10 appearances as a starter.
Baltimore Orioles Player Prop Facts
- Carlos Narvaez has recorded at least one hit in each of his seven previous appearances in day games against AL Central teams that held a winning record.
- Trevor Rogers has recorded six or more strikeouts in each of his last six appearances with the Orioles as favorites.
- Trevor Rogers has recorded a win in four of his last five appearances in day games against AL teams that held a winning record.
- Colton Cowser has hit a home run in three of the Orioles’ last four day games against opponents that held a winning record.
Cleveland Guardians Player Prop Facts
- Jo Adell has hit a home run in each of the Guardians’ last two games as road underdogs.
- Joey Cantillo has recorded six or more strikeouts in four of his last five road appearances against AL opponents that held a losing record.
- Steven Kwan has recorded at least one hit in each of his last eight appearances with the Guardians as road underdogs.
Orioles vs Guardians Prediction
Baltimore comes into this matchup on a lengthy losing streak and they have scored one total run in their last three games. The Orioles are 34-38 at home this year, while the Guardians are 37-32 on the road. Cleveland is coming off of a series win against Detroit, but all three wins came by exactly one run. The Guardians are starting Cantillo, who has allowed 4, 2, 1, 1, and 1 earned run in his last five starts, while Rogers has allowed 2, 6, 3, 2, and 2 earned runs in his last five outings. Take Cleveland and the plus money here.