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Orioles vs Guardians Prediction 9/9/26 MLB Picks Today

Cleveland Guardians (74-72) vs. Baltimore Orioles (70-76)
September 9, 2026 6:35 pm EDT
The Line: Baltimore Orioles -111 / Cleveland Guardians -108; Over/Under: 9
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In this article we will formulate an Orioles vs Guardians prediction for this MLB game on Wednesday, September 9th at Camden Yards in Baltimore, Maryland. Let’s take a look at the prediction for this MLB matchup. 

Baltimore Orioles Betting Preview

The Baltimore Orioles are 70-76 this year after they split the first two games by scores of 6-4 and 5-9. In game two, Baltimore cut the deficit to 6-5 in the fifth inning, but couldn’t score anymore runs in the loss. The Orioles recorded six hits and they committed one error in the game, while they were led by Alonso, who went 2-4 with one home run and two RBIs. Young allowed eight hits and six earned runs over 3.2 innings for the loss, while Nunez threw 1.1 innings in relief. Prior to this series, Baltimore lost all four against the Red Sox and two out of three against the Rockies. 


This season, Baltimore has a 4.14 ERA with a 1.34 WHIP and a .253 opponent batting average, while they have scored 652 runs with a .234 batting average and a .316 on base percentage. Pete Alonso has led the Orioles with 34 home runs and 97 RBIs, while Gunnar Henderson has added 22 home runs and 57 RBIs. The projected starting pitcher for Baltimore is Shane Baz, who is 5-15 with a 3.91 ERA and a 1.33 WHIP over 163.1 innings pitched this year. 

Cleveland Guardians Betting Preview

The Cleveland Guardians are 74-72 this season after they won game two by a score of 9-5 last night. Cleveland scored six runs in the first three innings, but they needed three in the seventh to put the game away. The Guardians recorded 12 hits in the game and they were led by Bazzana, who went 1-4 with one home run and three RBIs. Bibee allowed six hits and five earned runs over 4.1 innings, while Herrin got the win and Yoho picked up a hold. Prior to this series, Cleveland won three out of four against the Tigers, but lost two out of three against the Blue Jays before that.

This season, Cleveland has a 3.77 ERA with a 1.26 WHIP and a .237 opponent batting average, while they have scored 593 runs with a .237 batting average and a .314 on base percentage. Chase DeLauter has led the Guardians with 13 home runs and 60 RBIs, while Angel Martinez has added 14 home runs and 50 RBIs. The projected starting pitcher for Cleveland is Foster Griffin, who is 15-4 with a 3.26 ERA and a 1.14 WHIP over 160.1 innings pitched this season. 

Why the Baltimore Orioles will win

  • The Orioles have won each of their last five games against AL Central opponents following a loss.
  • The Guardians have lost 10 of their last 12 games against AL East opponents.
  • The Guardians have failed to cover the run line in eight of their last nine games as underdogs against the Orioles following a road win.
  • The Orioles have covered the run line in each of their last five games against AL Central opponents following a loss.
  • The Guardians have trailed after 5 innings in five of their last six games as underdogs against AL East opponents.
  • The Guardians have trailed after 3 innings in five of their last six games.

Why the Cleveland Guardians will win

  • The Guardians have won eight of their last nine Wednesday games as road underdogs against AL opponents.
  • The Orioles have lost seven of their last eight games.
  • The Guardians have covered the run line in each of their last 10 Wednesday games as road underdogs against AL opponents.
  • The Orioles have failed to cover the run line each of their last four night games against AL Central opponents that held a winning record.
  • The Guardians have led after 5 innings in five of their last six night games against the Orioles.
  • The Orioles have trailed after 3 innings in six of their last eight home night games.

Total Runs Facts

  • Eight of the Orioles’ last nine games against AL Central opponents have gone OVER the total runs line.
  • Seven of the Guardians’ last eight games as underdogs against the Orioles have gone OVER the total runs line.
  • There has been no run scored during the first inning in seven of the Guardians’ last eight road games against AL East opponents.
  • There has been no run scored during the first inning in six of Shane Baz’s last seven home appearances as a starter.

Baltimore Orioles Player Prop Facts

  • Shane Baz has recorded five or more strikeouts in eight of his last nine appearances against AL opponents that held a winning record.
  • Jackson Holliday has recorded at least one hit in each of his seven previous appearances with the Orioles as favorites against the Guardians.
  • Yohel Pozo has hit a home run in each of his last two appearances with his team as a home favorite against AL opponents.

Cleveland Guardians Player Prop Facts

  • Travis Bazzana has hit a home run in each of his last two appearances in night games.
  • Chase DeLauter has recorded at least one hit in each of the Guardians’ last 10 Wednesday games against AL opponents that held a losing record.
  • Foster Griffin has recorded a win in each of his last three road appearances against opponents that held a losing record.

Orioles vs Guardians Prediction 

Cleveland was able to tie the series at one with a win on Tuesday, but they have alternated wins and losses over their last five games. The Guardians are 38-33 on the road this year, while the Orioles are 35-39 at home. Baltimore has lost four of their last five games and they have scored one run or fewer in three of those five. The Orioles are starting Baz, who has allowed two earned runs or fewer in back to back starts, while Griffin has allowed two earned runs or fewer in four of his last five starts. Take the under here. 

David Racey's Free Pick: Under 9

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David Racey

David started writing about sports in 2015, but sports has been his passion for as long as he can remember. David spends most of his free time watching pretty much anything sports related from Baseball to Tennis and everything in between. David likes to analyze statistics and recent results to form an unbiased opinion on whatever game he is breaking down. Follow David on Twitter at @itsyerboi41

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