Cardinals vs White Sox Prediction 9/12/26 MLB Picks Today

In this article we will formulate a Cardinals vs White Sox prediction for this MLB game on Saturday, September 12th at Busch Stadium in St. Louis, Missouri. Let’s take a look at the prediction for this MLB matchup. 

St. Louis Cardinals Betting Preview

The St. Louis Cardinals are 73-75 this year after they won game one by a score of 7-3 last night. St. Louis was tied at two in the third inning, but they scored the next five runs to pull away with the win. The Cardinals recorded 13 hits in the game and they were led by Baez, who went 3-4 with two RBIs. Liberatore allowed six hits and two earned runs over 4.1 innings, while Graceffo got the win in relief. Prior to this series, St. Louis lost all three against the Giants, but did win two out of three against the Rockies before that. 

This season, St. Louis has a 4.30 ERA with a 1.35 WHIP and a .255 opponent batting average, while they have scored 675 runs with a .244 batting average and a .317 on base percentage. Jordan Walker has led the Cardinals with 28 home runs and 100 RBIs, while Alec Burleson has added 22 home runs and 106 RBIs. The projected starting pitcher for St. Louis is Kyle Leahy, who is 10-4 with a 3.41 ERA and a 1.33 WHIP over 132.0 innings pitched this year. 

Chicago White Sox Betting Preview

The Chicago White Sox are 75-72 this season after they lost game one by a score of 3-7 yesterday. Chicago scored two runs in the first three innings, but scored just once in the last six innings for the loss. The White Sox recorded nine hits in the game and they were led by Meidroth, who went 2-4 with two home runs and two RBIs. Kay allowed five hits and three earned runs over 4.0 innings for the loss, while Richards allowed three earned runs in relief. Prior to this series, Chicago lost all three against the Pirates, but did win two out of three against the Twins before that. 

This season, Chicago has a 4.15 ERA with a 1.31 WHIP and a .242 opponent batting average, while they have scored 688 runs with a .235 batting average and a .318 on base percentage. Colson Montgomery has led the White Sox with 31 home runs and 83 RBIs, while Miguel Vargas has added 30 home runs and 79 RBIs. The projected starting pitcher for Chicago is Luis Castillo, who is 4-11 with a 5.57 ERA and a 1.46 WHIP over 126.0 innings pitched this season. 

Why the St. Louis Cardinals will win

• The White Sox have lost each of their last nine night games against NL Central opponents following a road loss.
• The Cardinals have won each of their last four games against the White Sox.
• The White Sox have failed to cover the run line in each of their last six games against NL opponents.
• The Cardinals have covered the run line in eight of their last nine home games after playing the previous day.
• The White Sox have trailed after 5 innings in each of their last six night games against NL opponents.
• The Cardinals have won the first inning in three of their last four games against AL Central opponents.
• The Cardinals have led after 3 innings in each of their last four games against the White Sox.

Why the Chicago White Sox will win

• The Cardinals have lost seven of their last eight games as favorites following a home win.
• The underdogs have won three of the White Sox’s last four games.
• The Cardinals have failed to cover the run line in each of their last 10 games as favorites following a win.
• The underdogs have covered the run line in nine of the Cardinals’ last 10 games at Busch Stadium.
• The Cardinals have trailed after 5 innings in three of their last four night games.
• The Cardinals have lost the first inning in four of their last five games.

Total Runs Facts

• Each of the Cardinals’ last seven night games against AL Central opponents have gone OVER the total runs line.
• Ten of the White Sox’s last 12 night games as underdogs have gone OVER the total runs line.
• There has been at least one run scored in the first inning in each of the Cardinals’ last six games as home favorites against AL Central opponents.
• There has been at least one run scored in the first inning in nine of the White Sox’s last 10 games as underdogs against NL Central opponents.

St. Louis Cardinals Player Prop Facts

• Joshua Baez has hit at least one home run in three of the Cardinals’ last four Saturday games.
• Nathan Church has recorded at least one hit in each of his last 12 appearances with the Cardinals as favorites.
• Kyle Leahy has recorded three or more strikeouts in each of his last nine appearances.

Chicago White Sox Player Prop Facts

• Chase Meidroth has hit at least one home run in each of the White Sox’s last two road games against NL opponents that held a losing record.
• Luis Castillo has recorded five or more strikeouts in 15 of his last 17 appearances against NL Central opponents that held a losing record.
• Miguel Vargas has recorded at least one hit in each of the White Sox’s last 16 road games against NL opponents.

Cardinals vs White Sox Prediction 

Chicago comes into this matchup on a four game losing streak and they have been outscored 22-8 in that span. The White Sox are 32-41 on the road this year, while the Cardinals are 35-38 at home. St. Louis has dropped three of their last four games, but they have scored 5+ runs in four of their last five. The Cardinals are starting Leahy, who has allowed one earned run or fewer in four of his last five starts, while Castillo has allowed 4+ earned runs in three straight outings. Take the Cardinals to win here.