Giants vs Cardinals Prediction 9/14/26 MLB Picks Today

In this article, we will formulate a Giants vs Cardinals Prediction for this MLB matchup on Monday, September 14^th in the opening game of this series. Let’s take a look at the prediction for this MLB matchup.

St. Louis Cardinals Preview

The St. Louis Cardinals have a 74-76 record this season and are sitting in the 4th place of the NL Central. They have a 36-39 home record and are coming off a 1-3 home loss against the White Sox. They will face the Nationals and the Pirates next.

The St. Louis Cardinals have a .243 batting average this season, .317 OBP and .385 Slugging percentage. St. Louis’s pitching staff has a 4.29 ERA and 1.35 WHIP. Alec Burleson is the team’s best hitter with a .283 batting average, leading the team in RBI with 109, while Jordan Walker adds a team-high 28 home runs.

Quinn Mathews (L) is the projected starting pitcher for the Cardinals, and he has a 1-3 record, 4.11 ERA and 1.50 WHIP.

San Francisco Giants Preview

The San Francisco Giants have a 62-88 record this season and are sitting in the 4th place of the NL West. They have a 26-49 away record and are coming off a 4-6 home loss against the Padres. They will face the Dodgers and the Twins next.

The San Francisco Giants have a .247 batting average this season, .308 OBP and .407 Slugging percentage. San Francisco’s pitching staff has a 4.38 ERA and 1.36 WHIP. Jung Hoo Lee is the team’s best hitter with a .276 batting average. Rafael Devers leads the team in RBI with 98 and adds a team-high 37 home runs.

Landen Roupp (R) is the projected starting pitcher for the Giants, and he has a 9-13 record, 4.00 ERA and 1.28 WHIP.

San Francisco Giants @ St. Louis Cardinals Betting Trends: September 14, 2026

• Probable Starting Pitcher: Quinn Mathews      Record this season: 1-3      ERA: 4.11
• Home Record: 1-0
• Last 5 against Giants: 0-1

Why the St. Louis Cardinals will win

• The Giants have lost 10 of their last 11 games at Busch Stadium following a loss.
• The home team has won each of the last four games between the Giants and Cardinals.
• The Cardinals have covered the run line in 10 of their last 11 home games after playing the previous day.
• The Giants have failed to cover the run line in seven of their last eight night games against the Cardinals following a loss.
• The Giants have trailed after 5 innings in each of their last four games.
• The Cardinals have led after 3 innings in four of their last five home games against NL West opponents.

• Probable Starting Pitcher: Landen Roupp      Record this season: 9-13      ERA: 4.00
• Road Record: 4-6
• Last 5 against Cardinals: 1-1

Why the San Francisco Giants will win

• The Cardinals have lost seven of their last eight games as favorites following a home win.
• The Giants have won each of their last six games against NL Central opponents following a loss.
• The Cardinals have failed to cover the run line in each of their last 18 games as favorites against NL West opponents following a win.
• The underdogs have covered the run line in each of the last 12 games between the Giants and Cardinals.
• The Giants have led after 3 innings in five of their last six night games against NL Central opponents.
• The Cardinals have lost the first inning in each of their last four games against opponents that held a losing record.
• The Giants have led after 5 innings in each of their last four night games against the Cardinals.

Total Runs Facts

• Each of the Giants’ last four games have gone OVER the total runs line.
• Six of the Cardinals’ last seven games as favorites against NL West opponents have gone OVER the total runs line.
• There has been at least one run scored in the first inning in each of the Giants’ last 13 night games.
• There has been at least one run scored in the first inning in seven of the Cardinals’ last eight games against NL opponents.

St. Louis Cardinals Player Prop Facts

• Ivan Herrera has hit a home run in five of the Cardinals’ last nine night games against NL West opponents that held a losing record.
• Ivan Herrera has recorded at least one hit in each of the Cardinals’ last 16 games against NL West opponents that held a losing record.
• Alec Burleson ranks T7th in the league in Hits (160) this season.

San Francisco Giants Player Prop Facts

• Osleivis Basabe has hit a home run in four of his last seven road appearances with the Giants against NL opponents.
• Landen Roupp has recorded six or more strikeouts in three of his last four road appearances against NL opponents that held a losing record.
• Bryce Eldridge has recorded at least one hit in each of his last 12 appearances in night games.

Matchup/League Facts

• The Cardinals rank 27th in the league for slugging percentage this season (.385).
• The Cardinals rank 4th in the league for home runs allowed this season (149).
• The Giants rank 30th in the league for walks this season (416).
• The Giants rank 1st in the league for home runs allowed this season (143).

Giants vs Cardinals Prediction

The Giants have won their last four meetings against the Cardinals but have lost their last two visits in Saint Louis.

In this Giants vs Cardinals Prediction, the Cardinals are coming as -130 home favorites. Both pitchers have been in good form, but they are both overachieving right now, as they both have a 4+ ERA this season. Both offenses have been scorching-hot, as they average 12.1 runs against the opposing starter throw hand combined in their last 10 games and as a result, they are 14-4 to the over in their last 18 games combined. The total is low based on the pitchers’ recent form, but I will take the over 7.5 in this one.